Transoral, flexible endoscopic suturing for treatment of GERD: A multicenter trial
Background: A totally transoral outpatient procedure for the treatment of GERD would be appealing. Methods: A multicenter trial was initiated that included 64 patients with GERD treated with an endoscopic suturing device. Inclusion criteria were 3 or more heartburn episodes per week while not taking...
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| Veröffentlicht in: | Gastrointestinal endoscopy 2001-04, Vol.53 (4), p.416-422 |
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| creator | Filipi, Charles J. Lehman, Glen A. Rothstein, Richard I. Raijman, Isaac Stiegmann, Gregory V. Waring, J.Patrick Hunter, John G. Gostout, Christopher J. Edmundowicz, Steven A. Dunne, Donal P. Watson, Patrice A. Cornet, Douglas A. |
| description | Background: A totally transoral outpatient procedure for the treatment of GERD would be appealing.
Methods: A multicenter trial was initiated that included 64 patients with GERD treated with an endoscopic suturing device. Inclusion criteria were 3 or more heartburn episodes per week while not taking medication, dependency on antisecretory medicine, and documented acid reflux by pH monitoring. Exclusion criteria were dysphagia, grade 3 or 4 esophagitis, obesity, and hiatus hernia greater than 2 cm in length. Patients underwent manometry, endoscopy, 24-hour pH monitoring, and symptom severity scoring before and after the procedure. Patients were randomized to a linear or circumferential plication configuration. Adverse procedural events were recorded.
Results: Mean 6-month symptom score changes demonstrated procedural efficacy. Heartburn severity and frequency as well as regurgitation all improved (
p > 0.0001 for each). Twenty-four−hour pH monitoring showed improvement in number of episodes below pH of 4 at 3 and 6 months (
p < 0.0007 and 0.0002) and percentage of total time the pH was less than 4 at 6 months (
p < 0.011). Plication configuration did not affect symptoms or pH monitoring results. One patient had a self-contained suture perforation that was successfully treated with antibiotics.
Conclusion: Endoscopic gastroplasty is safe. It is associated with reduced symptoms and medication use at 6 month follow-up in patients with uncomplicated GERD. (Gastrointest Endosc 2001;53:416-22.) |
| doi_str_mv | 10.1067/mge.2001.113502 |
| format | Article |
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Methods: A multicenter trial was initiated that included 64 patients with GERD treated with an endoscopic suturing device. Inclusion criteria were 3 or more heartburn episodes per week while not taking medication, dependency on antisecretory medicine, and documented acid reflux by pH monitoring. Exclusion criteria were dysphagia, grade 3 or 4 esophagitis, obesity, and hiatus hernia greater than 2 cm in length. Patients underwent manometry, endoscopy, 24-hour pH monitoring, and symptom severity scoring before and after the procedure. Patients were randomized to a linear or circumferential plication configuration. Adverse procedural events were recorded.
Results: Mean 6-month symptom score changes demonstrated procedural efficacy. Heartburn severity and frequency as well as regurgitation all improved (
p > 0.0001 for each). Twenty-four−hour pH monitoring showed improvement in number of episodes below pH of 4 at 3 and 6 months (
p < 0.0007 and 0.0002) and percentage of total time the pH was less than 4 at 6 months (
p < 0.011). Plication configuration did not affect symptoms or pH monitoring results. One patient had a self-contained suture perforation that was successfully treated with antibiotics.
Conclusion: Endoscopic gastroplasty is safe. It is associated with reduced symptoms and medication use at 6 month follow-up in patients with uncomplicated GERD. (Gastrointest Endosc 2001;53:416-22.)</description><identifier>ISSN: 0016-5107</identifier><identifier>EISSN: 1097-6779</identifier><identifier>DOI: 10.1067/mge.2001.113502</identifier><identifier>PMID: 11275879</identifier><identifier>CODEN: GAENBQ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Biological and medical sciences ; Esophagus ; Gastroesophageal Reflux - prevention & control ; Gastroesophageal Reflux - surgery ; Gastroplasty - adverse effects ; Gastroplasty - methods ; Gastroscopy - methods ; Heartburn - diagnosis ; Humans ; Hydrogen-Ion Concentration ; Manometry ; Medical sciences ; Quality of Life ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Suture Techniques</subject><ispartof>Gastrointestinal endoscopy, 2001-04, Vol.53 (4), p.416-422</ispartof><rights>2001 The American Society for Gastrointestinal Endoscopy</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-91dc886211d86c38bf2375e58b9791a2d2963851b9169ad0b67bdc463cfe17ff3</citedby><cites>FETCH-LOGICAL-c400t-91dc886211d86c38bf2375e58b9791a2d2963851b9169ad0b67bdc463cfe17ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1067/mge.2001.113502$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=939535$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11275879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Filipi, Charles J.</creatorcontrib><creatorcontrib>Lehman, Glen A.</creatorcontrib><creatorcontrib>Rothstein, Richard I.</creatorcontrib><creatorcontrib>Raijman, Isaac</creatorcontrib><creatorcontrib>Stiegmann, Gregory V.</creatorcontrib><creatorcontrib>Waring, J.Patrick</creatorcontrib><creatorcontrib>Hunter, John G.</creatorcontrib><creatorcontrib>Gostout, Christopher J.</creatorcontrib><creatorcontrib>Edmundowicz, Steven A.</creatorcontrib><creatorcontrib>Dunne, Donal P.</creatorcontrib><creatorcontrib>Watson, Patrice A.</creatorcontrib><creatorcontrib>Cornet, Douglas A.</creatorcontrib><title>Transoral, flexible endoscopic suturing for treatment of GERD: A multicenter trial</title><title>Gastrointestinal endoscopy</title><addtitle>Gastrointest Endosc</addtitle><description>Background: A totally transoral outpatient procedure for the treatment of GERD would be appealing.
Methods: A multicenter trial was initiated that included 64 patients with GERD treated with an endoscopic suturing device. Inclusion criteria were 3 or more heartburn episodes per week while not taking medication, dependency on antisecretory medicine, and documented acid reflux by pH monitoring. Exclusion criteria were dysphagia, grade 3 or 4 esophagitis, obesity, and hiatus hernia greater than 2 cm in length. Patients underwent manometry, endoscopy, 24-hour pH monitoring, and symptom severity scoring before and after the procedure. Patients were randomized to a linear or circumferential plication configuration. Adverse procedural events were recorded.
Results: Mean 6-month symptom score changes demonstrated procedural efficacy. Heartburn severity and frequency as well as regurgitation all improved (
p > 0.0001 for each). Twenty-four−hour pH monitoring showed improvement in number of episodes below pH of 4 at 3 and 6 months (
p < 0.0007 and 0.0002) and percentage of total time the pH was less than 4 at 6 months (
p < 0.011). Plication configuration did not affect symptoms or pH monitoring results. One patient had a self-contained suture perforation that was successfully treated with antibiotics.
Conclusion: Endoscopic gastroplasty is safe. It is associated with reduced symptoms and medication use at 6 month follow-up in patients with uncomplicated GERD. (Gastrointest Endosc 2001;53:416-22.)</description><subject>Biological and medical sciences</subject><subject>Esophagus</subject><subject>Gastroesophageal Reflux - prevention & control</subject><subject>Gastroesophageal Reflux - surgery</subject><subject>Gastroplasty - adverse effects</subject><subject>Gastroplasty - methods</subject><subject>Gastroscopy - methods</subject><subject>Heartburn - diagnosis</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Manometry</subject><subject>Medical sciences</subject><subject>Quality of Life</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Suture Techniques</subject><issn>0016-5107</issn><issn>1097-6779</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10EFLHDEUwPEgLbrVnnuTQMFTZ82bOMnEm6hVQRDEnkMmeZGUzGRNZkr77ZtlF3vqKZD83iP8CfkCbA1MyPPxFdctY7AG4B1rD8gKmJKNkFJ9IKv6IJoOmDwin0r5yRjrWw6H5AiglV0v1Yo8v2QzlZRN_EZ9xN9hiEhxcqnYtAmWlmVecpheqU-ZzhnNPOI00-Tp3e3zzSW9ouMS52DrJW5BMPGEfPQmFvy8P4_Jj--3L9f3zePT3cP11WNjLxibGwXO9r1oAVwvLO8H33LZYdcPSiowrWuV4H0HgwKhjGODkIOzF4JbjyC958fkbLd3k9PbgmXWYygWYzQTpqVoKRmTgokKz3fQ5lRKRq83OYwm_9HA9Dajrhn1NqPeZawTp_vVyzCi--f33Sr4ugemWBN9jWhDeXeKq453VamdwprhV8Csiw04WXQho521S-G_X_gLK3OM7A</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Filipi, Charles J.</creator><creator>Lehman, Glen A.</creator><creator>Rothstein, Richard I.</creator><creator>Raijman, Isaac</creator><creator>Stiegmann, Gregory V.</creator><creator>Waring, J.Patrick</creator><creator>Hunter, John G.</creator><creator>Gostout, Christopher J.</creator><creator>Edmundowicz, Steven A.</creator><creator>Dunne, Donal P.</creator><creator>Watson, Patrice A.</creator><creator>Cornet, Douglas A.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Transoral, flexible endoscopic suturing for treatment of GERD: A multicenter trial</title><author>Filipi, Charles J. ; Lehman, Glen A. ; Rothstein, Richard I. ; Raijman, Isaac ; Stiegmann, Gregory V. ; Waring, J.Patrick ; Hunter, John G. ; Gostout, Christopher J. ; Edmundowicz, Steven A. ; Dunne, Donal P. ; Watson, Patrice A. ; Cornet, Douglas A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-91dc886211d86c38bf2375e58b9791a2d2963851b9169ad0b67bdc463cfe17ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Esophagus</topic><topic>Gastroesophageal Reflux - prevention & control</topic><topic>Gastroesophageal Reflux - surgery</topic><topic>Gastroplasty - adverse effects</topic><topic>Gastroplasty - methods</topic><topic>Gastroscopy - methods</topic><topic>Heartburn - diagnosis</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Manometry</topic><topic>Medical sciences</topic><topic>Quality of Life</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the digestive system</topic><topic>Suture Techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Filipi, Charles J.</creatorcontrib><creatorcontrib>Lehman, Glen A.</creatorcontrib><creatorcontrib>Rothstein, Richard I.</creatorcontrib><creatorcontrib>Raijman, Isaac</creatorcontrib><creatorcontrib>Stiegmann, Gregory V.</creatorcontrib><creatorcontrib>Waring, J.Patrick</creatorcontrib><creatorcontrib>Hunter, John G.</creatorcontrib><creatorcontrib>Gostout, Christopher J.</creatorcontrib><creatorcontrib>Edmundowicz, Steven A.</creatorcontrib><creatorcontrib>Dunne, Donal P.</creatorcontrib><creatorcontrib>Watson, Patrice A.</creatorcontrib><creatorcontrib>Cornet, Douglas A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastrointestinal endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Filipi, Charles J.</au><au>Lehman, Glen A.</au><au>Rothstein, Richard I.</au><au>Raijman, Isaac</au><au>Stiegmann, Gregory V.</au><au>Waring, J.Patrick</au><au>Hunter, John G.</au><au>Gostout, Christopher J.</au><au>Edmundowicz, Steven A.</au><au>Dunne, Donal P.</au><au>Watson, Patrice A.</au><au>Cornet, Douglas A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transoral, flexible endoscopic suturing for treatment of GERD: A multicenter trial</atitle><jtitle>Gastrointestinal endoscopy</jtitle><addtitle>Gastrointest Endosc</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>53</volume><issue>4</issue><spage>416</spage><epage>422</epage><pages>416-422</pages><issn>0016-5107</issn><eissn>1097-6779</eissn><coden>GAENBQ</coden><abstract>Background: A totally transoral outpatient procedure for the treatment of GERD would be appealing.
Methods: A multicenter trial was initiated that included 64 patients with GERD treated with an endoscopic suturing device. Inclusion criteria were 3 or more heartburn episodes per week while not taking medication, dependency on antisecretory medicine, and documented acid reflux by pH monitoring. Exclusion criteria were dysphagia, grade 3 or 4 esophagitis, obesity, and hiatus hernia greater than 2 cm in length. Patients underwent manometry, endoscopy, 24-hour pH monitoring, and symptom severity scoring before and after the procedure. Patients were randomized to a linear or circumferential plication configuration. Adverse procedural events were recorded.
Results: Mean 6-month symptom score changes demonstrated procedural efficacy. Heartburn severity and frequency as well as regurgitation all improved (
p > 0.0001 for each). Twenty-four−hour pH monitoring showed improvement in number of episodes below pH of 4 at 3 and 6 months (
p < 0.0007 and 0.0002) and percentage of total time the pH was less than 4 at 6 months (
p < 0.011). Plication configuration did not affect symptoms or pH monitoring results. One patient had a self-contained suture perforation that was successfully treated with antibiotics.
Conclusion: Endoscopic gastroplasty is safe. It is associated with reduced symptoms and medication use at 6 month follow-up in patients with uncomplicated GERD. (Gastrointest Endosc 2001;53:416-22.)</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>11275879</pmid><doi>10.1067/mge.2001.113502</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Gastrointestinal endoscopy, 2001-04, Vol.53 (4), p.416-422 |
| issn | 0016-5107 1097-6779 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences Esophagus Gastroesophageal Reflux - prevention & control Gastroesophageal Reflux - surgery Gastroplasty - adverse effects Gastroplasty - methods Gastroscopy - methods Heartburn - diagnosis Humans Hydrogen-Ion Concentration Manometry Medical sciences Quality of Life Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Suture Techniques |
| title | Transoral, flexible endoscopic suturing for treatment of GERD: A multicenter trial |
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