Synthesis of anthraquinonyl glucosaminosides and studies on the influence of aglycone hydroxyl substitution on superoxide generation, DNA binding, and antimicrobial properties

A series of anthraquinonyl glucosaminosides (10a-e) were synthesized by Koenigs-Knorr glycosidation of the corresponding aglycones (11a-e) with bromo sugar 12 followed by saponification. These glycosides were intended to serve as models to study the role played by the hydroxyl substituents on the ag...

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Veröffentlicht in:Journal of medicinal chemistry 1986-09, Vol.29 (9), p.1709-1714
Hauptverfasser: Abramson, Hanley N, Banning, Jon W, Nachtman, Joseph P, Roginski, Edward T, Sardessai, Maniklal, Wormser, Henry C, Wu, Jender, Nagia, Ziad, Schroeder, Ronald R, Bernardo, Maria Margarida
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Sprache:eng
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