Mycosis fungoides: Evaluation of immunohistochemical criteria for the early diagnosis of the disease and differentiation between stages
Lesional skin specimens from twenty-eight patients with mycosis fungoides were studied by evaluating immunohistochemical criteria, primarily with monoclonal antibodies. It was demonstrated that significant differences exist between the control and the premycotic-stage group in regard to the monoclon...
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| Veröffentlicht in: | Journal of the American Academy of Dermatology 1986-08, Vol.15 (2), p.237-245 |
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| creator | Tosca, Androniki D. Varelzidis, Anthony G. Economidou, Jane Stratigos, John D. |
| description | Lesional skin specimens from twenty-eight patients with mycosis fungoides were studied by evaluating immunohistochemical criteria, primarily with monoclonal antibodies. It was demonstrated that significant differences exist between the control and the premycotic-stage group in regard to the monoclonal antibodies BE1, BE2, and OKT9. The detection of specific antigenic determinants on the surface of cell populations early in the course of the disease seems to be of considerable value for the early diagnosis of the disease. Statistically significant differences were found between the premycotic stage and the plaque stage in regard to T lymphocytes, macrophages, OKT6
+, OKT4
+, OKT8
+, and BE2
+ cells in the dermal infiltrate. Significant differences were also shown between the plaque and tumorous groups, concerning macrophages, T cells, and OKT9
+ cells in the dermis, as well as epidermal dendritic cells. Differences between stages may supplement histologic data for the follow-up of the disease with or without treatment. |
| doi_str_mv | 10.1016/S0190-9622(86)70163-1 |
| format | Article |
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+, OKT4
+, OKT8
+, and BE2
+ cells in the dermal infiltrate. Significant differences were also shown between the plaque and tumorous groups, concerning macrophages, T cells, and OKT9
+ cells in the dermis, as well as epidermal dendritic cells. Differences between stages may supplement histologic data for the follow-up of the disease with or without treatment.</description><identifier>ISSN: 0190-9622</identifier><identifier>EISSN: 1097-6787</identifier><identifier>DOI: 10.1016/S0190-9622(86)70163-1</identifier><identifier>PMID: 3528242</identifier><identifier>CODEN: JAADDB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Antibodies, Monoclonal - immunology ; Biological and medical sciences ; Hematologic and hematopoietic diseases ; Histocytochemistry ; Humans ; Immunoenzyme Techniques ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Macrophages - pathology ; Medical sciences ; Mycosis Fungoides - diagnosis ; Mycosis Fungoides - immunology ; Mycosis Fungoides - pathology ; Naphthol AS D Esterase - analysis ; Neoplasm Staging ; Skin Neoplasms - diagnosis ; Skin Neoplasms - immunology ; Skin Neoplasms - pathology ; T-Lymphocytes - immunology ; T-Lymphocytes - pathology</subject><ispartof>Journal of the American Academy of Dermatology, 1986-08, Vol.15 (2), p.237-245</ispartof><rights>1986 American Academy of Dermatology, Inc.</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-231bea0866177505b3b5ef4222566426d6099ff4fdedbca7c1917eb3d2d8bfbe3</citedby><cites>FETCH-LOGICAL-c389t-231bea0866177505b3b5ef4222566426d6099ff4fdedbca7c1917eb3d2d8bfbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0190962286701631$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8787435$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3528242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tosca, Androniki D.</creatorcontrib><creatorcontrib>Varelzidis, Anthony G.</creatorcontrib><creatorcontrib>Economidou, Jane</creatorcontrib><creatorcontrib>Stratigos, John D.</creatorcontrib><title>Mycosis fungoides: Evaluation of immunohistochemical criteria for the early diagnosis of the disease and differentiation between stages</title><title>Journal of the American Academy of Dermatology</title><addtitle>J Am Acad Dermatol</addtitle><description>Lesional skin specimens from twenty-eight patients with mycosis fungoides were studied by evaluating immunohistochemical criteria, primarily with monoclonal antibodies. It was demonstrated that significant differences exist between the control and the premycotic-stage group in regard to the monoclonal antibodies BE1, BE2, and OKT9. The detection of specific antigenic determinants on the surface of cell populations early in the course of the disease seems to be of considerable value for the early diagnosis of the disease. Statistically significant differences were found between the premycotic stage and the plaque stage in regard to T lymphocytes, macrophages, OKT6
+, OKT4
+, OKT8
+, and BE2
+ cells in the dermal infiltrate. Significant differences were also shown between the plaque and tumorous groups, concerning macrophages, T cells, and OKT9
+ cells in the dermis, as well as epidermal dendritic cells. Differences between stages may supplement histologic data for the follow-up of the disease with or without treatment.</description><subject>Antibodies, Monoclonal - immunology</subject><subject>Biological and medical sciences</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Histocytochemistry</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Macrophages - pathology</subject><subject>Medical sciences</subject><subject>Mycosis Fungoides - diagnosis</subject><subject>Mycosis Fungoides - immunology</subject><subject>Mycosis Fungoides - pathology</subject><subject>Naphthol AS D Esterase - analysis</subject><subject>Neoplasm Staging</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - immunology</subject><subject>Skin Neoplasms - pathology</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - pathology</subject><issn>0190-9622</issn><issn>1097-6787</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EKkPhESp5gRAs0vonsRM2FaoKVGrFAlhbjn09Y5TYxXaK5gl4bTw_mi0rW_d-59g6B6ELSi4poeLqO6EDaQbB2PtefJB1xBv6DK0oGWQjZC-fo9UJeYle5fyLEDK0XJ6hM96xnrVshf4-bE3MPmO3hHX0FvJHfPukp0UXHwOODvt5XkLc-Fyi2cDsjZ6wSb5A8hq7mHDZAAadpi22Xq_D3q3qdmPrM-gMWAdb785BglD8wXqE8gcg4Fz0GvJr9MLpKcOb43mOfn6-_XHztbn_9uXu5tN9Y3g_lIZxOoImvRBUyo50Ix87cC1jrBOiZcIKMgzOtc6CHY2Whg5Uwsgts_3oRuDn6N3B9zHF3wvkomafDUyTDhCXrKQkRFLSV7A7gCbFnBM49Zj8rNNWUaJ2Bah9AWqXruqF2hegaNVdHB9YxhnsSXVMvO7fHvc61yhd0sH4fML6WlzLu4pdHzCoYTx5SCobD8GA9QlMUTb6_3zkH7nYpYY</recordid><startdate>19860801</startdate><enddate>19860801</enddate><creator>Tosca, Androniki D.</creator><creator>Varelzidis, Anthony G.</creator><creator>Economidou, Jane</creator><creator>Stratigos, John D.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860801</creationdate><title>Mycosis fungoides: Evaluation of immunohistochemical criteria for the early diagnosis of the disease and differentiation between stages</title><author>Tosca, Androniki D. ; Varelzidis, Anthony G. ; Economidou, Jane ; Stratigos, John D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-231bea0866177505b3b5ef4222566426d6099ff4fdedbca7c1917eb3d2d8bfbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Antibodies, Monoclonal - immunology</topic><topic>Biological and medical sciences</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Histocytochemistry</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Macrophages - pathology</topic><topic>Medical sciences</topic><topic>Mycosis Fungoides - diagnosis</topic><topic>Mycosis Fungoides - immunology</topic><topic>Mycosis Fungoides - pathology</topic><topic>Naphthol AS D Esterase - analysis</topic><topic>Neoplasm Staging</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - immunology</topic><topic>Skin Neoplasms - pathology</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tosca, Androniki D.</creatorcontrib><creatorcontrib>Varelzidis, Anthony G.</creatorcontrib><creatorcontrib>Economidou, Jane</creatorcontrib><creatorcontrib>Stratigos, John D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tosca, Androniki D.</au><au>Varelzidis, Anthony G.</au><au>Economidou, Jane</au><au>Stratigos, John D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mycosis fungoides: Evaluation of immunohistochemical criteria for the early diagnosis of the disease and differentiation between stages</atitle><jtitle>Journal of the American Academy of Dermatology</jtitle><addtitle>J Am Acad Dermatol</addtitle><date>1986-08-01</date><risdate>1986</risdate><volume>15</volume><issue>2</issue><spage>237</spage><epage>245</epage><pages>237-245</pages><issn>0190-9622</issn><eissn>1097-6787</eissn><coden>JAADDB</coden><abstract>Lesional skin specimens from twenty-eight patients with mycosis fungoides were studied by evaluating immunohistochemical criteria, primarily with monoclonal antibodies. It was demonstrated that significant differences exist between the control and the premycotic-stage group in regard to the monoclonal antibodies BE1, BE2, and OKT9. The detection of specific antigenic determinants on the surface of cell populations early in the course of the disease seems to be of considerable value for the early diagnosis of the disease. Statistically significant differences were found between the premycotic stage and the plaque stage in regard to T lymphocytes, macrophages, OKT6
+, OKT4
+, OKT8
+, and BE2
+ cells in the dermal infiltrate. Significant differences were also shown between the plaque and tumorous groups, concerning macrophages, T cells, and OKT9
+ cells in the dermis, as well as epidermal dendritic cells. Differences between stages may supplement histologic data for the follow-up of the disease with or without treatment.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>3528242</pmid><doi>10.1016/S0190-9622(86)70163-1</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of the American Academy of Dermatology, 1986-08, Vol.15 (2), p.237-245 |
| issn | 0190-9622 1097-6787 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antibodies, Monoclonal - immunology Biological and medical sciences Hematologic and hematopoietic diseases Histocytochemistry Humans Immunoenzyme Techniques Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Macrophages - pathology Medical sciences Mycosis Fungoides - diagnosis Mycosis Fungoides - immunology Mycosis Fungoides - pathology Naphthol AS D Esterase - analysis Neoplasm Staging Skin Neoplasms - diagnosis Skin Neoplasms - immunology Skin Neoplasms - pathology T-Lymphocytes - immunology T-Lymphocytes - pathology |
| title | Mycosis fungoides: Evaluation of immunohistochemical criteria for the early diagnosis of the disease and differentiation between stages |
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