Neural mechanisms involved in the delay of gastric emptying and gastrointestinal transit of liquid after thoracic spinal cord transection in awake rats
Spinal cord transection (SCT) delays gastric emptying (GE), and intestinal and gastrointestinal (GI) transit of liquid in awake rats. This study evaluates the neural mechanisms involved in this phenomenon. Male Wistar rats ( N=147) were fasted for 16 h and had the left jugular vein cannulated follow...
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| Veröffentlicht in: | Autonomic neuroscience 2001-02, Vol.87 (1), p.52-58 |
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| creator | de Assis Aquino Gondim, Francisco Leite Rodrigues, Cleonisio Ronaldo Vasconcelos da Graça, José Duarte Camurça, Flávio Menezes Piancó de Alencar, Hamilton Aguiar dos Santos, Armenio Hélio Rola, Francisco |
| description | Spinal cord transection (SCT) delays gastric emptying (GE), and intestinal and gastrointestinal (GI) transit of liquid in awake rats. This study evaluates the neural mechanisms involved in this phenomenon. Male Wistar rats (
N=147) were fasted for 16 h and had the left jugular vein cannulated followed by laminectomy or laminectomy+complete SCT between T
4 and T
5 vertebrae. The next day, a test meal (1.5 ml of a phenol red solution, 0.5 mg/ml in 5% glucose) was administered by gavage feeding and 10 min later cervical dislocation was performed. Dye recovery in the stomach, and proximal, mid and distal small intestine was determined by spectrophotometry. SCT inhibited GE and GI transit since it increased gastric recovery by 71.3% and decreased mid small intestine recovery by 100% (
P |
| doi_str_mv | 10.1016/S1566-0702(00)00261-7 |
| format | Article |
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N=147) were fasted for 16 h and had the left jugular vein cannulated followed by laminectomy or laminectomy+complete SCT between T
4 and T
5 vertebrae. The next day, a test meal (1.5 ml of a phenol red solution, 0.5 mg/ml in 5% glucose) was administered by gavage feeding and 10 min later cervical dislocation was performed. Dye recovery in the stomach, and proximal, mid and distal small intestine was determined by spectrophotometry. SCT inhibited GE and GI transit since it increased gastric recovery by 71.3% and decreased mid small intestine recovery by 100% (
P<0.05). Subdiaphragmatic vagotomy, celiac ganglionectomy+section of the splanchnic nerves, i.v. hexamethonium (20 mg/kg) or yohimbine (3 mg/kg) prevented the development of the SCT effect on GE and GI transit. Pretreatment with i.v. naloxone (2 mg/kg),
l-NAME (3 mg/kg) or propranolol (2 mg/kg) was ineffective. Bilateral adrenalectomy or guanethidine (10 mg/kg) increased the magnitude of the GE inhibition, while i.v. prazosin (1 mg/kg) or atropine (0.5 mg/kg) decreased the magnitude but did not abolish the GE inhibition. In summary, the inhibition of GI motility observed 1 day after thoracic SCT in awake rats seems to involve vagal and possibly splanchnic pathways.</description><identifier>ISSN: 1566-0702</identifier><identifier>EISSN: 1872-7484</identifier><identifier>DOI: 10.1016/S1566-0702(00)00261-7</identifier><identifier>PMID: 11280307</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Autonomic Nervous System - drug effects ; Autonomic Nervous System - pathology ; Autonomic Nervous System - physiopathology ; Biological and medical sciences ; Cardiovascular Physiological Phenomena - drug effects ; Celiac ganglion ; Digestive System - drug effects ; Digestive System - innervation ; Digestive System Physiological Phenomena ; Fundamental and applied biological sciences. Psychology ; Ganglia, Sympathetic - physiology ; Ganglia, Sympathetic - surgery ; Ganglionectomy - adverse effects ; Gastric emptying ; Gastric Emptying - drug effects ; Gastric Emptying - physiology ; Gastrointestinal Diseases - drug therapy ; Gastrointestinal Diseases - etiology ; Gastrointestinal Diseases - physiopathology ; Gastrointestinal motility ; Gastrointestinal Motility - drug effects ; Gastrointestinal Motility - physiology ; Indicators and Reagents - pharmacokinetics ; Male ; Phenolsulfonphthalein - pharmacokinetics ; Rats ; Rats, Wistar ; Spinal Cord - pathology ; Spinal Cord - physiopathology ; Spinal Cord Injuries - complications ; Spinal cord injury ; Splanchnic Nerves - physiology ; Splanchnic Nerves - surgery ; Stomach ; Sympathectomy - adverse effects ; Thoracic Vertebrae ; Time Factors ; Vagotomy - adverse effects ; Vagus nerve ; Vertebrates: digestive system</subject><ispartof>Autonomic neuroscience, 2001-02, Vol.87 (1), p.52-58</ispartof><rights>2001 Elsevier Science B.V.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-ad4dcc63fa5f801105897516ee74e98322b64e57f7d12525447f93994ee7ab8a3</citedby><cites>FETCH-LOGICAL-c484t-ad4dcc63fa5f801105897516ee74e98322b64e57f7d12525447f93994ee7ab8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1566070200002617$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=959806$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11280307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Assis Aquino Gondim, Francisco</creatorcontrib><creatorcontrib>Leite Rodrigues, Cleonisio</creatorcontrib><creatorcontrib>Ronaldo Vasconcelos da Graça, José</creatorcontrib><creatorcontrib>Duarte Camurça, Flávio</creatorcontrib><creatorcontrib>Menezes Piancó de Alencar, Hamilton</creatorcontrib><creatorcontrib>Aguiar dos Santos, Armenio</creatorcontrib><creatorcontrib>Hélio Rola, Francisco</creatorcontrib><title>Neural mechanisms involved in the delay of gastric emptying and gastrointestinal transit of liquid after thoracic spinal cord transection in awake rats</title><title>Autonomic neuroscience</title><addtitle>Auton Neurosci</addtitle><description>Spinal cord transection (SCT) delays gastric emptying (GE), and intestinal and gastrointestinal (GI) transit of liquid in awake rats. This study evaluates the neural mechanisms involved in this phenomenon. Male Wistar rats (
N=147) were fasted for 16 h and had the left jugular vein cannulated followed by laminectomy or laminectomy+complete SCT between T
4 and T
5 vertebrae. The next day, a test meal (1.5 ml of a phenol red solution, 0.5 mg/ml in 5% glucose) was administered by gavage feeding and 10 min later cervical dislocation was performed. Dye recovery in the stomach, and proximal, mid and distal small intestine was determined by spectrophotometry. SCT inhibited GE and GI transit since it increased gastric recovery by 71.3% and decreased mid small intestine recovery by 100% (
P<0.05). Subdiaphragmatic vagotomy, celiac ganglionectomy+section of the splanchnic nerves, i.v. hexamethonium (20 mg/kg) or yohimbine (3 mg/kg) prevented the development of the SCT effect on GE and GI transit. Pretreatment with i.v. naloxone (2 mg/kg),
l-NAME (3 mg/kg) or propranolol (2 mg/kg) was ineffective. Bilateral adrenalectomy or guanethidine (10 mg/kg) increased the magnitude of the GE inhibition, while i.v. prazosin (1 mg/kg) or atropine (0.5 mg/kg) decreased the magnitude but did not abolish the GE inhibition. In summary, the inhibition of GI motility observed 1 day after thoracic SCT in awake rats seems to involve vagal and possibly splanchnic pathways.</description><subject>Animals</subject><subject>Autonomic Nervous System - drug effects</subject><subject>Autonomic Nervous System - pathology</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular Physiological Phenomena - drug effects</subject><subject>Celiac ganglion</subject><subject>Digestive System - drug effects</subject><subject>Digestive System - innervation</subject><subject>Digestive System Physiological Phenomena</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia, Sympathetic - physiology</subject><subject>Ganglia, Sympathetic - surgery</subject><subject>Ganglionectomy - adverse effects</subject><subject>Gastric emptying</subject><subject>Gastric Emptying - drug effects</subject><subject>Gastric Emptying - physiology</subject><subject>Gastrointestinal Diseases - drug therapy</subject><subject>Gastrointestinal Diseases - etiology</subject><subject>Gastrointestinal Diseases - physiopathology</subject><subject>Gastrointestinal motility</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Gastrointestinal Motility - physiology</subject><subject>Indicators and Reagents - pharmacokinetics</subject><subject>Male</subject><subject>Phenolsulfonphthalein - pharmacokinetics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spinal Cord - pathology</subject><subject>Spinal Cord - physiopathology</subject><subject>Spinal Cord Injuries - complications</subject><subject>Spinal cord injury</subject><subject>Splanchnic Nerves - physiology</subject><subject>Splanchnic Nerves - surgery</subject><subject>Stomach</subject><subject>Sympathectomy - adverse effects</subject><subject>Thoracic Vertebrae</subject><subject>Time Factors</subject><subject>Vagotomy - adverse effects</subject><subject>Vagus nerve</subject><subject>Vertebrates: digestive system</subject><issn>1566-0702</issn><issn>1872-7484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0Eou3AI4AsISFYBK6TOE5WCFUUkCpYAGvrjn3TGhJ7ajuD5kl4XTw_wJKVr6zv3J9zGHsi4JUA0b3-ImTXVaCgfgHwEqDuRKXusXPRq7pSbd_eL_Uf5IxdpPQdAHoYuofsTIi6hwbUOfv1iZaIE5_J3KJ3aU7c-W2YtmRLwfMtcUsT7ngY-Q2mHJ3hNG_yzvkbjt4eP4PzmVJ2vnTKEX1yeS-Y3N3iLMcxUyytQkRT5Glz4EyI9giTyS74_Tj8iT-IR8zpEXsw4pTo8eldsW9X775efqiuP7__ePn2ujLlxFyhba0xXTOiHHsQAmQ_KCk6ItXS0Dd1ve5akmpUVtSylm2rxqEZhrYAuO6xWbHnx76bGO6WcoOeXTI0TegpLEkrBdA1si2gPIImhpQijXoT3YxxpwXofSL6kIje260B9CERrYru6WnAsp7J_lOdIijAsxOAyeA0FkeMS3-5QQ592WDF3hwpKmZsHUWdjCNvyLpY_NM2uP8s8hsjwap5</recordid><startdate>20010220</startdate><enddate>20010220</enddate><creator>de Assis Aquino Gondim, Francisco</creator><creator>Leite Rodrigues, Cleonisio</creator><creator>Ronaldo Vasconcelos da Graça, José</creator><creator>Duarte Camurça, Flávio</creator><creator>Menezes Piancó de Alencar, Hamilton</creator><creator>Aguiar dos Santos, Armenio</creator><creator>Hélio Rola, Francisco</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010220</creationdate><title>Neural mechanisms involved in the delay of gastric emptying and gastrointestinal transit of liquid after thoracic spinal cord transection in awake rats</title><author>de Assis Aquino Gondim, Francisco ; Leite Rodrigues, Cleonisio ; Ronaldo Vasconcelos da Graça, José ; Duarte Camurça, Flávio ; Menezes Piancó de Alencar, Hamilton ; Aguiar dos Santos, Armenio ; Hélio Rola, Francisco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-ad4dcc63fa5f801105897516ee74e98322b64e57f7d12525447f93994ee7ab8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Autonomic Nervous System - drug effects</topic><topic>Autonomic Nervous System - pathology</topic><topic>Autonomic Nervous System - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular Physiological Phenomena - drug effects</topic><topic>Celiac ganglion</topic><topic>Digestive System - drug effects</topic><topic>Digestive System - innervation</topic><topic>Digestive System Physiological Phenomena</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia, Sympathetic - physiology</topic><topic>Ganglia, Sympathetic - surgery</topic><topic>Ganglionectomy - adverse effects</topic><topic>Gastric emptying</topic><topic>Gastric Emptying - drug effects</topic><topic>Gastric Emptying - physiology</topic><topic>Gastrointestinal Diseases - drug therapy</topic><topic>Gastrointestinal Diseases - etiology</topic><topic>Gastrointestinal Diseases - physiopathology</topic><topic>Gastrointestinal motility</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Gastrointestinal Motility - physiology</topic><topic>Indicators and Reagents - pharmacokinetics</topic><topic>Male</topic><topic>Phenolsulfonphthalein - pharmacokinetics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Spinal Cord - pathology</topic><topic>Spinal Cord - physiopathology</topic><topic>Spinal Cord Injuries - complications</topic><topic>Spinal cord injury</topic><topic>Splanchnic Nerves - physiology</topic><topic>Splanchnic Nerves - surgery</topic><topic>Stomach</topic><topic>Sympathectomy - adverse effects</topic><topic>Thoracic Vertebrae</topic><topic>Time Factors</topic><topic>Vagotomy - adverse effects</topic><topic>Vagus nerve</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Assis Aquino Gondim, Francisco</creatorcontrib><creatorcontrib>Leite Rodrigues, Cleonisio</creatorcontrib><creatorcontrib>Ronaldo Vasconcelos da Graça, José</creatorcontrib><creatorcontrib>Duarte Camurça, Flávio</creatorcontrib><creatorcontrib>Menezes Piancó de Alencar, Hamilton</creatorcontrib><creatorcontrib>Aguiar dos Santos, Armenio</creatorcontrib><creatorcontrib>Hélio Rola, Francisco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Autonomic neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Assis Aquino Gondim, Francisco</au><au>Leite Rodrigues, Cleonisio</au><au>Ronaldo Vasconcelos da Graça, José</au><au>Duarte Camurça, Flávio</au><au>Menezes Piancó de Alencar, Hamilton</au><au>Aguiar dos Santos, Armenio</au><au>Hélio Rola, Francisco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural mechanisms involved in the delay of gastric emptying and gastrointestinal transit of liquid after thoracic spinal cord transection in awake rats</atitle><jtitle>Autonomic neuroscience</jtitle><addtitle>Auton Neurosci</addtitle><date>2001-02-20</date><risdate>2001</risdate><volume>87</volume><issue>1</issue><spage>52</spage><epage>58</epage><pages>52-58</pages><issn>1566-0702</issn><eissn>1872-7484</eissn><abstract>Spinal cord transection (SCT) delays gastric emptying (GE), and intestinal and gastrointestinal (GI) transit of liquid in awake rats. This study evaluates the neural mechanisms involved in this phenomenon. Male Wistar rats (
N=147) were fasted for 16 h and had the left jugular vein cannulated followed by laminectomy or laminectomy+complete SCT between T
4 and T
5 vertebrae. The next day, a test meal (1.5 ml of a phenol red solution, 0.5 mg/ml in 5% glucose) was administered by gavage feeding and 10 min later cervical dislocation was performed. Dye recovery in the stomach, and proximal, mid and distal small intestine was determined by spectrophotometry. SCT inhibited GE and GI transit since it increased gastric recovery by 71.3% and decreased mid small intestine recovery by 100% (
P<0.05). Subdiaphragmatic vagotomy, celiac ganglionectomy+section of the splanchnic nerves, i.v. hexamethonium (20 mg/kg) or yohimbine (3 mg/kg) prevented the development of the SCT effect on GE and GI transit. Pretreatment with i.v. naloxone (2 mg/kg),
l-NAME (3 mg/kg) or propranolol (2 mg/kg) was ineffective. Bilateral adrenalectomy or guanethidine (10 mg/kg) increased the magnitude of the GE inhibition, while i.v. prazosin (1 mg/kg) or atropine (0.5 mg/kg) decreased the magnitude but did not abolish the GE inhibition. In summary, the inhibition of GI motility observed 1 day after thoracic SCT in awake rats seems to involve vagal and possibly splanchnic pathways.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11280307</pmid><doi>10.1016/S1566-0702(00)00261-7</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Autonomic Nervous System - drug effects Autonomic Nervous System - pathology Autonomic Nervous System - physiopathology Biological and medical sciences Cardiovascular Physiological Phenomena - drug effects Celiac ganglion Digestive System - drug effects Digestive System - innervation Digestive System Physiological Phenomena Fundamental and applied biological sciences. Psychology Ganglia, Sympathetic - physiology Ganglia, Sympathetic - surgery Ganglionectomy - adverse effects Gastric emptying Gastric Emptying - drug effects Gastric Emptying - physiology Gastrointestinal Diseases - drug therapy Gastrointestinal Diseases - etiology Gastrointestinal Diseases - physiopathology Gastrointestinal motility Gastrointestinal Motility - drug effects Gastrointestinal Motility - physiology Indicators and Reagents - pharmacokinetics Male Phenolsulfonphthalein - pharmacokinetics Rats Rats, Wistar Spinal Cord - pathology Spinal Cord - physiopathology Spinal Cord Injuries - complications Spinal cord injury Splanchnic Nerves - physiology Splanchnic Nerves - surgery Stomach Sympathectomy - adverse effects Thoracic Vertebrae Time Factors Vagotomy - adverse effects Vagus nerve Vertebrates: digestive system |
| title | Neural mechanisms involved in the delay of gastric emptying and gastrointestinal transit of liquid after thoracic spinal cord transection in awake rats |
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