Involvement of adrenal medulla grafts in the open field behavior
Immunohistochemical and behavioral techniques were used to study the effects of adrenal medulla grafts, implanted in striatum after bilateral kainic acid (KA) lesions of this structure, on the open field behavior of mice. KA-induced behavioral changes in leaning, grooming and locomotor activity of t...
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| Veröffentlicht in: | Behavioural brain research 2001-06, Vol.121 (1), p.29-37 |
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| creator | Jousselin-Hosaja, M Venault, P Tobin, C Joubert, C Delacour, J Chapouthier, G |
| description | Immunohistochemical and behavioral techniques were used to study the effects of adrenal medulla grafts, implanted in striatum after bilateral kainic acid (KA) lesions of this structure, on the open field behavior of mice. KA-induced behavioral changes in leaning, grooming and locomotor activity of the open field test were significantly improved after grafting of the adrenal medulla, and in some respects, fully restored. Immunohistochemical identification showed that grafts contained neuron-like cells with a tyrosine hydroxylase (TH), phenylethanolamine
N-methyltransferase, gamma-aminobutyric acid (GABA), choline acetyltransferase (ChAT), and enkephalin-like immunostainings. A likely interpretation of this complex pattern of results is that adrenal medullary grafts may restore the deficits of GABAergic neurons which in turn reverse the abnormalities in emotionality and locomotion. Neurobiologically, these behavioral improvements probably involve GABAergic and catecholaminergic factors of adrenal medulla grafts, although other neuroactive substances, such as acetylcholine and enkephalins, cannot be excluded. |
| doi_str_mv | 10.1016/S0166-4328(00)00380-6 |
| format | Article |
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N-methyltransferase, gamma-aminobutyric acid (GABA), choline acetyltransferase (ChAT), and enkephalin-like immunostainings. A likely interpretation of this complex pattern of results is that adrenal medullary grafts may restore the deficits of GABAergic neurons which in turn reverse the abnormalities in emotionality and locomotion. Neurobiologically, these behavioral improvements probably involve GABAergic and catecholaminergic factors of adrenal medulla grafts, although other neuroactive substances, such as acetylcholine and enkephalins, cannot be excluded.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/S0166-4328(00)00380-6</identifier><identifier>PMID: 11275282</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adrenal medulla ; Adrenal Medulla - transplantation ; Animals ; Arousal - physiology ; Behavior ; Biological and medical sciences ; Brain Mapping ; Catecholamines - physiology ; Choline O-Acetyltransferase - physiology ; Corpus Striatum - physiology ; Development. Senescence. Regeneration. Transplantation ; Fundamental and applied biological sciences. Psychology ; gamma-Aminobutyric Acid - physiology ; Graft ; Grooming - physiology ; Immunohistochemistry ; Kainic acid ; Male ; Mice ; Motor Activity - physiology ; Mouse ; Nerve Regeneration - physiology ; Neurons - physiology ; Open field ; Phenethylamines ; Phenylethanolamine N-Methyltransferase - physiology ; Social Environment ; Striatum ; Tyrosine 3-Monooxygenase - physiology ; Vertebrates: nervous system and sense organs</subject><ispartof>Behavioural brain research, 2001-06, Vol.121 (1), p.29-37</ispartof><rights>2001 Elsevier Science B.V.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-99db6c9edabd65db1ebf4ddfa67af4ec368a64dd2ececfc65b03b09ce52e2ac23</citedby><cites>FETCH-LOGICAL-c421t-99db6c9edabd65db1ebf4ddfa67af4ec368a64dd2ececfc65b03b09ce52e2ac23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0166-4328(00)00380-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1076371$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11275282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jousselin-Hosaja, M</creatorcontrib><creatorcontrib>Venault, P</creatorcontrib><creatorcontrib>Tobin, C</creatorcontrib><creatorcontrib>Joubert, C</creatorcontrib><creatorcontrib>Delacour, J</creatorcontrib><creatorcontrib>Chapouthier, G</creatorcontrib><title>Involvement of adrenal medulla grafts in the open field behavior</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>Immunohistochemical and behavioral techniques were used to study the effects of adrenal medulla grafts, implanted in striatum after bilateral kainic acid (KA) lesions of this structure, on the open field behavior of mice. KA-induced behavioral changes in leaning, grooming and locomotor activity of the open field test were significantly improved after grafting of the adrenal medulla, and in some respects, fully restored. Immunohistochemical identification showed that grafts contained neuron-like cells with a tyrosine hydroxylase (TH), phenylethanolamine
N-methyltransferase, gamma-aminobutyric acid (GABA), choline acetyltransferase (ChAT), and enkephalin-like immunostainings. A likely interpretation of this complex pattern of results is that adrenal medullary grafts may restore the deficits of GABAergic neurons which in turn reverse the abnormalities in emotionality and locomotion. Neurobiologically, these behavioral improvements probably involve GABAergic and catecholaminergic factors of adrenal medulla grafts, although other neuroactive substances, such as acetylcholine and enkephalins, cannot be excluded.</description><subject>Adrenal medulla</subject><subject>Adrenal Medulla - transplantation</subject><subject>Animals</subject><subject>Arousal - physiology</subject><subject>Behavior</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Catecholamines - physiology</subject><subject>Choline O-Acetyltransferase - physiology</subject><subject>Corpus Striatum - physiology</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gamma-Aminobutyric Acid - physiology</subject><subject>Graft</subject><subject>Grooming - physiology</subject><subject>Immunohistochemistry</subject><subject>Kainic acid</subject><subject>Male</subject><subject>Mice</subject><subject>Motor Activity - physiology</subject><subject>Mouse</subject><subject>Nerve Regeneration - physiology</subject><subject>Neurons - physiology</subject><subject>Open field</subject><subject>Phenethylamines</subject><subject>Phenylethanolamine N-Methyltransferase - physiology</subject><subject>Social Environment</subject><subject>Striatum</subject><subject>Tyrosine 3-Monooxygenase - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78BCUHET1UJ2mTtCcV8WNhwYN6Dmky0Ui3XZPugv_erruoNy8zMDzzzvAQcsjgnAGTF09DkVmR8_IU4AwgLyGTG2TESsUzJYpqk4x-kB2ym9I7ABQg2DbZYYwrwUs-IlfjdtE1C5xi29POU-MitqahU3TzpjH0NRrfJxpa2r8h7WbYUh-wcbTGN7MIXdwnW940CQ_WfY-83N0-3zxkk8f78c31JLMFZ31WVa6WtkJnaieFqxnWvnDOG6mML9DmsjRyGHC0aL2Vooa8hsqi4MiN5fkeOVnlzmL3McfU62lIFocfW-zmSSsFIEGW_4JMlYKBWCaKFWhjl1JEr2cxTE381Az00rH-dqyXAjWA_nas5bB3tD4wrwdNv1trqQNwvAZMsqbx0bQ2pD_pSuaKDdjlCsNB2yJg1MkGbC26ENH22nXhn0--AK0emUk</recordid><startdate>20010601</startdate><enddate>20010601</enddate><creator>Jousselin-Hosaja, M</creator><creator>Venault, P</creator><creator>Tobin, C</creator><creator>Joubert, C</creator><creator>Delacour, J</creator><creator>Chapouthier, G</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20010601</creationdate><title>Involvement of adrenal medulla grafts in the open field behavior</title><author>Jousselin-Hosaja, M ; Venault, P ; Tobin, C ; Joubert, C ; Delacour, J ; Chapouthier, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-99db6c9edabd65db1ebf4ddfa67af4ec368a64dd2ececfc65b03b09ce52e2ac23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adrenal medulla</topic><topic>Adrenal Medulla - transplantation</topic><topic>Animals</topic><topic>Arousal - physiology</topic><topic>Behavior</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Catecholamines - physiology</topic><topic>Choline O-Acetyltransferase - physiology</topic><topic>Corpus Striatum - physiology</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gamma-Aminobutyric Acid - physiology</topic><topic>Graft</topic><topic>Grooming - physiology</topic><topic>Immunohistochemistry</topic><topic>Kainic acid</topic><topic>Male</topic><topic>Mice</topic><topic>Motor Activity - physiology</topic><topic>Mouse</topic><topic>Nerve Regeneration - physiology</topic><topic>Neurons - physiology</topic><topic>Open field</topic><topic>Phenethylamines</topic><topic>Phenylethanolamine N-Methyltransferase - physiology</topic><topic>Social Environment</topic><topic>Striatum</topic><topic>Tyrosine 3-Monooxygenase - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jousselin-Hosaja, M</creatorcontrib><creatorcontrib>Venault, P</creatorcontrib><creatorcontrib>Tobin, C</creatorcontrib><creatorcontrib>Joubert, C</creatorcontrib><creatorcontrib>Delacour, J</creatorcontrib><creatorcontrib>Chapouthier, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jousselin-Hosaja, M</au><au>Venault, P</au><au>Tobin, C</au><au>Joubert, C</au><au>Delacour, J</au><au>Chapouthier, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of adrenal medulla grafts in the open field behavior</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2001-06-01</date><risdate>2001</risdate><volume>121</volume><issue>1</issue><spage>29</spage><epage>37</epage><pages>29-37</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>Immunohistochemical and behavioral techniques were used to study the effects of adrenal medulla grafts, implanted in striatum after bilateral kainic acid (KA) lesions of this structure, on the open field behavior of mice. KA-induced behavioral changes in leaning, grooming and locomotor activity of the open field test were significantly improved after grafting of the adrenal medulla, and in some respects, fully restored. Immunohistochemical identification showed that grafts contained neuron-like cells with a tyrosine hydroxylase (TH), phenylethanolamine
N-methyltransferase, gamma-aminobutyric acid (GABA), choline acetyltransferase (ChAT), and enkephalin-like immunostainings. A likely interpretation of this complex pattern of results is that adrenal medullary grafts may restore the deficits of GABAergic neurons which in turn reverse the abnormalities in emotionality and locomotion. Neurobiologically, these behavioral improvements probably involve GABAergic and catecholaminergic factors of adrenal medulla grafts, although other neuroactive substances, such as acetylcholine and enkephalins, cannot be excluded.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>11275282</pmid><doi>10.1016/S0166-4328(00)00380-6</doi><tpages>9</tpages></addata></record> |
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| subjects | Adrenal medulla Adrenal Medulla - transplantation Animals Arousal - physiology Behavior Biological and medical sciences Brain Mapping Catecholamines - physiology Choline O-Acetyltransferase - physiology Corpus Striatum - physiology Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - physiology Graft Grooming - physiology Immunohistochemistry Kainic acid Male Mice Motor Activity - physiology Mouse Nerve Regeneration - physiology Neurons - physiology Open field Phenethylamines Phenylethanolamine N-Methyltransferase - physiology Social Environment Striatum Tyrosine 3-Monooxygenase - physiology Vertebrates: nervous system and sense organs |
| title | Involvement of adrenal medulla grafts in the open field behavior |
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