Estimation of Bone Matrix Apparent Stiffness Variation Caused by Osteocyte Lacunar Size and Density
The role of osteocyte lacunar size and density on the apparent stiffness of bone matrix was predicted using a mechanical model from the literature. Lacunar size and lacunar density for different bones from different gender and age groups were used to predict the range of matrix apparent stiffness va...
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| Veröffentlicht in: | Journal of biomechanical engineering 2001-02, Vol.123 (1), p.10-17 |
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| creator | Yeni, Yener N Vashishth, Deepak Fyhrie, David P |
| description | The role of osteocyte lacunar size and density on the apparent stiffness of bone matrix was predicted using a mechanical model from the literature. Lacunar size and lacunar density for different bones from different gender and age groups were used to predict the range of matrix apparent stiffness values for human cortical and cancellous tissue. The results suggest that bone matrix apparent stiffness depends on tissue type (cortical versus cancellous), age, and gender, the magnitudes of the effects being significant but small in all cases. Males had a higher predicted matrix apparent stiffness than females for vertebral cancellous bone p |
| doi_str_mv | 10.1115/1.1338123 |
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Lacunar size and lacunar density for different bones from different gender and age groups were used to predict the range of matrix apparent stiffness values for human cortical and cancellous tissue. The results suggest that bone matrix apparent stiffness depends on tissue type (cortical versus cancellous), age, and gender, the magnitudes of the effects being significant but small in all cases. Males had a higher predicted matrix apparent stiffness than females for vertebral cancellous bone p<10−7)and the difference increased with age p=0.0007. In contrast, matrix apparent stiffness was not different between males and females for femoral cortical bone and increased with age in both males p<0.0001 and females p<0.0364. Osteocyte lacunar density and size may cause significant gender and age-related variations in bone matrix apparent stiffness. The magnitude of variations in matrix apparent stiffness was small within the physiological range of lacunar size and density for healthy bone, whereas the variations can be profound in certain pathological cases. It was proposed that the mechanical effects of osteocyte density be uncoupled from their biological effects by controlling lacunar size in normal bone.</description><identifier>ISSN: 0148-0731</identifier><identifier>EISSN: 1528-8951</identifier><identifier>DOI: 10.1115/1.1338123</identifier><identifier>PMID: 11277294</identifier><identifier>CODEN: JBENDY</identifier><language>eng</language><publisher>New York, NY: ASME</publisher><subject>Adolescent ; Adult ; Aged ; Aging - physiology ; Biological and medical sciences ; Biomedical engineering ; Bone Density ; Bone Matrix - cytology ; Bone Matrix - physiology ; Elasticity ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Mathematical models ; Middle Aged ; Models, Biological ; Osteocytes - cytology ; Osteocytes - physiology ; Reference Values ; Sex Factors ; Skeleton and joints ; Stiffness matrix ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Journal of biomechanical engineering, 2001-02, Vol.123 (1), p.10-17</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a360t-525e84e2c26da1f9b86de88797b64ff4af642c7dd1b969b4db60f6f01c117af43</citedby><cites>FETCH-LOGICAL-a360t-525e84e2c26da1f9b86de88797b64ff4af642c7dd1b969b4db60f6f01c117af43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,38520</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=902275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11277294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeni, Yener N</creatorcontrib><creatorcontrib>Vashishth, Deepak</creatorcontrib><creatorcontrib>Fyhrie, David P</creatorcontrib><title>Estimation of Bone Matrix Apparent Stiffness Variation Caused by Osteocyte Lacunar Size and Density</title><title>Journal of biomechanical engineering</title><addtitle>J Biomech Eng</addtitle><addtitle>J Biomech Eng</addtitle><description>The role of osteocyte lacunar size and density on the apparent stiffness of bone matrix was predicted using a mechanical model from the literature. Lacunar size and lacunar density for different bones from different gender and age groups were used to predict the range of matrix apparent stiffness values for human cortical and cancellous tissue. The results suggest that bone matrix apparent stiffness depends on tissue type (cortical versus cancellous), age, and gender, the magnitudes of the effects being significant but small in all cases. Males had a higher predicted matrix apparent stiffness than females for vertebral cancellous bone p<10−7)and the difference increased with age p=0.0007. In contrast, matrix apparent stiffness was not different between males and females for femoral cortical bone and increased with age in both males p<0.0001 and females p<0.0364. Osteocyte lacunar density and size may cause significant gender and age-related variations in bone matrix apparent stiffness. The magnitude of variations in matrix apparent stiffness was small within the physiological range of lacunar size and density for healthy bone, whereas the variations can be profound in certain pathological cases. It was proposed that the mechanical effects of osteocyte density be uncoupled from their biological effects by controlling lacunar size in normal bone.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Biomedical engineering</subject><subject>Bone Density</subject><subject>Bone Matrix - cytology</subject><subject>Bone Matrix - physiology</subject><subject>Elasticity</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Osteocytes - cytology</subject><subject>Osteocytes - physiology</subject><subject>Reference Values</subject><subject>Sex Factors</subject><subject>Skeleton and joints</subject><subject>Stiffness matrix</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0148-0731</issn><issn>1528-8951</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0L2LFDEcxvEgireeFtaCBATBYs788j7luZ4vsHLFqW34TSaBHLuZNcmA61_vyA5aWj3Nh6f4EvIc2BUAqLdwBUJY4OIB2YDitrO9godkw0DajhkBF-RJrfeMAVjJHpMLAG4M7-WG-Jva0gFbmjKdIn035UC_YCvpJ70-HrGE3OhdSzHmUCv9jiWd7RbnGkY6nOhtbWHypxboDv2csdC79CtQzCN9H3JN7fSUPIq4r-HZupfk24ebr9tP3e724-ft9a5DoVnrFFfBysA91yNC7Aerx2Ct6c2gZYwSo5bcm3GEodf9IMdBs6gjAw9gMEpxSV6ff49l-jGH2twhVR_2e8xhmqszhjHFLPsv5CCl0Kpf4Jsz9GWqtYTojmWpVU4OmPuT3oFb0y_25Xo6D4cw_pNr6wW8WgFWj_tYMPtU_7qecW7Uol6cFdZDcPfTXPLSzEnFBLPiN2vBk0w</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Yeni, Yener N</creator><creator>Vashishth, Deepak</creator><creator>Fyhrie, David P</creator><general>ASME</general><general>American Society of Mechanical Engineers</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010201</creationdate><title>Estimation of Bone Matrix Apparent Stiffness Variation Caused by Osteocyte Lacunar Size and Density</title><author>Yeni, Yener N ; Vashishth, Deepak ; Fyhrie, David P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a360t-525e84e2c26da1f9b86de88797b64ff4af642c7dd1b969b4db60f6f01c117af43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Biomedical engineering</topic><topic>Bone Density</topic><topic>Bone Matrix - cytology</topic><topic>Bone Matrix - physiology</topic><topic>Elasticity</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Osteocytes - cytology</topic><topic>Osteocytes - physiology</topic><topic>Reference Values</topic><topic>Sex Factors</topic><topic>Skeleton and joints</topic><topic>Stiffness matrix</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeni, Yener N</creatorcontrib><creatorcontrib>Vashishth, Deepak</creatorcontrib><creatorcontrib>Fyhrie, David P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomechanical engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeni, Yener N</au><au>Vashishth, Deepak</au><au>Fyhrie, David P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimation of Bone Matrix Apparent Stiffness Variation Caused by Osteocyte Lacunar Size and Density</atitle><jtitle>Journal of biomechanical engineering</jtitle><stitle>J Biomech Eng</stitle><addtitle>J Biomech Eng</addtitle><date>2001-02-01</date><risdate>2001</risdate><volume>123</volume><issue>1</issue><spage>10</spage><epage>17</epage><pages>10-17</pages><issn>0148-0731</issn><eissn>1528-8951</eissn><coden>JBENDY</coden><abstract>The role of osteocyte lacunar size and density on the apparent stiffness of bone matrix was predicted using a mechanical model from the literature. Lacunar size and lacunar density for different bones from different gender and age groups were used to predict the range of matrix apparent stiffness values for human cortical and cancellous tissue. The results suggest that bone matrix apparent stiffness depends on tissue type (cortical versus cancellous), age, and gender, the magnitudes of the effects being significant but small in all cases. Males had a higher predicted matrix apparent stiffness than females for vertebral cancellous bone p<10−7)and the difference increased with age p=0.0007. In contrast, matrix apparent stiffness was not different between males and females for femoral cortical bone and increased with age in both males p<0.0001 and females p<0.0364. Osteocyte lacunar density and size may cause significant gender and age-related variations in bone matrix apparent stiffness. The magnitude of variations in matrix apparent stiffness was small within the physiological range of lacunar size and density for healthy bone, whereas the variations can be profound in certain pathological cases. It was proposed that the mechanical effects of osteocyte density be uncoupled from their biological effects by controlling lacunar size in normal bone.</abstract><cop>New York, NY</cop><pub>ASME</pub><pmid>11277294</pmid><doi>10.1115/1.1338123</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aging - physiology Biological and medical sciences Biomedical engineering Bone Density Bone Matrix - cytology Bone Matrix - physiology Elasticity Female Fundamental and applied biological sciences. Psychology Humans Male Mathematical models Middle Aged Models, Biological Osteocytes - cytology Osteocytes - physiology Reference Values Sex Factors Skeleton and joints Stiffness matrix Vertebrates: osteoarticular system, musculoskeletal system |
| title | Estimation of Bone Matrix Apparent Stiffness Variation Caused by Osteocyte Lacunar Size and Density |
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