Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine

Garlic has been used as a traditional medicine for prevention and treatment of cardiovascular diseases. However, the molecular mechanism of garlic’s pharmacological action has not been clearly elucidated. We examined here the effect of garlic extract and its major component, S-allyl cysteine (SAC),...

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Veröffentlicht in:	Free radical biology & medicine 2001-04, Vol.30 (7), p.747-756
Hauptverfasser:	Kim, Ki-Mo, Chun, Sun-Bum, Koo, Myoung-Sook, Choi, Won-Jin, Kim, Tae-Woong, Kwon, Young-Guen, Chung, Hun-Taeg, Billiar, Timothy R, Kim, Young-Myeong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Cell Line Cells, Cultured Cyclic GMP - biosynthesis Cysteine - analogs & derivatives Cysteine - pharmacology Endothelial cells Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Female Free radicals Garlic - chemistry Garlic extract Gene Expression - drug effects Hepatocytes - drug effects Hepatocytes - metabolism Humans Interferon-gamma - pharmacology Lipopolysaccharides - pharmacology Macrophages Macrophages - drug effects Macrophages - metabolism Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Male Mice Mice, Inbred BALB C Muscle, Smooth NF-kappa B - antagonists & inhibitors Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type II Plants, Medicinal Promoter Regions, Genetic Rats Rats, Sprague-Dawley RNA, Messenger - analysis S-allyl cysteine Umbilical Veins
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