Effect of Ibuprofen on Gross Pathology, Bacterial Count, and Levels of Prostaglandin E2 in Experimental Staphylococcal Osteomyelitis

Infections with Staphylococcus aureus were induced in rat tibiae without sclerosing agents. Animals received ibuprofen or 0.9% NaCI. Both ibuprofen-treated and control animals developed a progressively more-destructive disease over 12 days. Gross tibial pathology was significantly reduced in animals...

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Veröffentlicht in:	The Journal of infectious diseases 1986-10, Vol.154 (4), p.627-630
Hauptverfasser:	Rissing, J. Peter, Buxton, Thomas B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone and Bones - pathology Bones, joints and connective tissue. Antiinflammatory agents Dinoprostone Ibuprofen - pharmacology Ibuprofen - therapeutic use Male Medical sciences Osteomyelitis - drug therapy Osteomyelitis - metabolism Osteomyelitis - microbiology Osteomyelitis - pathology Pharmacology. Drug treatments Prostaglandins E - metabolism Rats Rats, Inbred Strains Staphylococcal Infections - drug therapy Staphylococcal Infections - metabolism Staphylococcal Infections - microbiology Staphylococcal Infections - pathology Staphylococcus aureus - drug effects Tibia
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