The molecular machinery for lysosome biogenesis

The lysosome serves as a site for delivery of materials targeted for removal from the eukaryotic cell. The mechanisms underlying the biogenesis of this organelle are currently the subject of renewed interest due to advances in our understanding of the protein sorting machinery. Genetic model systems...

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Veröffentlicht in:	BioEssays 2001-04, Vol.23 (4), p.333-343
Hauptverfasser:	Mullins, Chris, Bonifacino, Juan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Protein Complex alpha Subunits Adaptor Proteins, Vesicular Transport ADP-Ribosylation Factors - metabolism Alkaline Phosphatase - metabolism Animals Biological Transport Carrier Proteins - metabolism Eukaryotic Cells Humans Lysosomes - metabolism Lysosomes - physiology Membrane Proteins - metabolism Phosphatidylinositols - metabolism ras Proteins - metabolism Saccharomyces cerevisiae - genetics SNARE Proteins trans-Golgi Network - metabolism trans-Golgi Network - physiology Vacuoles Vesicular Transport Proteins
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