High-performance liquid chromatographic analysis of the sulfation of 4-hydroxypropranolol enantiomers by monkey liver cytosol

We developed a new high‐performance liquid chromatographic method using an ODS column and a chiral column for the assay of racemic 4‐OH‐PL sulfate and enantiomeric 4‐OH‐PL sulfates, respectively. The method was successfully applied to measure phenolsulfotransferase (PST) activities for 4‐OH‐PL in cy...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 2001, Vol.13 (3), p.140-147
Hauptverfasser:	Narimatsu, Shizuo, Kobayashi, Naoko, Asaoka, Kazuo, Masubuchi, Yasuhiro, Horie, Toshiharu, Hosokawa, Masakiyo, Ishikawa, Tsutomu, Ohmori, Shigeru, Kitada, Mitsukazu, Miyano, Junko, Kataoka, Hiroyuki, Yamamoto, Shigeo
Format:	Artikel
Sprache:	eng
Schlagworte:	4-hydroxypropranolol Adult Aged Animals Arylsulfotransferase - metabolism Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - metabolism Chromatography, High Pressure Liquid - methods Cytosol - enzymology Cytosol - metabolism Dogs enantioselectivity HPLC human and monkey liver cytosol Humans Kinetics Liver - enzymology Liver - metabolism Liver Neoplasms - enzymology Liver Neoplasms - metabolism Macaca Male Middle Aged Propranolol - analogs & derivatives Propranolol - metabolism Rabbits Rats Rats, Wistar Species Specificity Stereoisomerism sulfate enantiomer Sulfates - metabolism Tumor Cells, Cultured
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