Requirement for cell-bound proteases in the mechanism of human neutrophil activation with various stimuli

A cell membrane-associated protease/esterase has been implicated in the mechanism of "stimulus-secretion coupling" described for human neutrophil degranulation. In this regard, a broad spectrum of protease inhibitors were evaluated for their effects on granule enzyme release from neutrophi...

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Veröffentlicht in:	Inflammation 1986-09, Vol.10 (3), p.257-270
Hauptverfasser:	SMITH, R. J, SPEZIALE, S. C, SAM, L. M, JUSTEN, J. M, BOWMAN, B. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell metabolism, cell oxidation Cell physiology Cytoplasmic Granules - enzymology Cytoplasmic Granules - physiology Esterases - antagonists & inhibitors Esterases - physiology Exocytosis - drug effects Fundamental and applied biological sciences. Psychology Humans Membrane Proteins - physiology Molecular and cellular biology Neutrophils - drug effects Neutrophils - enzymology Neutrophils - secretion Peptide Hydrolases - physiology Protease Inhibitors - pharmacology Sulfhydryl Reagents - pharmacology
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