Microscopic Polyangiitis Presenting as Idiopathic Pulmonary Fibrosis: Is Anti-Neutrophilic Cytoplasmic Antibody Testing Indicated?
We report a 55-year old woman with microscopic polyangiitis who presented with idiopathic pulmonary fibrosis and 1 year later developed hematuria and proteinuria. She had a high serum level of perinuclear anti-neutrophilic cytoplasmic antibodies. Renal angiogram was normal. The diagnosis of microsco...
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| Veröffentlicht in: | The American journal of the medical sciences 2001-03, Vol.321 (3), p.201-202 |
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| container_title | The American journal of the medical sciences |
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| creator | Mansi, Ishak A. Sondhi, Damanpaul Opran, Adriana Ayinla, Raji Rosner, Fred |
| description | We report a 55-year old woman with microscopic polyangiitis who presented with idiopathic pulmonary fibrosis and 1 year later developed hematuria and proteinuria. She had a high serum level of perinuclear anti-neutrophilic cytoplasmic antibodies. Renal angiogram was normal. The diagnosis of microscopic polyangiitis was confirmed by renal biopsy, which showed pauci-immune crescentic glomerulonephritis.The patient received immunosuppressive therapy and improved markedly. Consideration of small vessel vasculitis is important in the differential diagnosis of idiopathic pulmonary fibrosis. |
| doi_str_mv | 10.1097/00000441-200103000-00009 |
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She had a high serum level of perinuclear anti-neutrophilic cytoplasmic antibodies. Renal angiogram was normal. The diagnosis of microscopic polyangiitis was confirmed by renal biopsy, which showed pauci-immune crescentic glomerulonephritis.The patient received immunosuppressive therapy and improved markedly. Consideration of small vessel vasculitis is important in the differential diagnosis of idiopathic pulmonary fibrosis.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/00000441-200103000-00009</identifier><identifier>PMID: 11269798</identifier><identifier>CODEN: AJMSA9</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Anti-neutrophilic cytoplasmic antibodies (ANCA) ; Antibodies, Antineutrophil Cytoplasmic - analysis ; Biological and medical sciences ; Female ; Glomerulonephritis ; Hematuria ; Humans ; Idiopathic pulmonary fibrosis ; Medical sciences ; Microscopic polyangiitis ; Middle Aged ; Proteinuria ; Pulmonary Fibrosis - complications ; Pulmonary Fibrosis - diagnosis ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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She had a high serum level of perinuclear anti-neutrophilic cytoplasmic antibodies. Renal angiogram was normal. The diagnosis of microscopic polyangiitis was confirmed by renal biopsy, which showed pauci-immune crescentic glomerulonephritis.The patient received immunosuppressive therapy and improved markedly. Consideration of small vessel vasculitis is important in the differential diagnosis of idiopathic pulmonary fibrosis.</description><subject>Anti-neutrophilic cytoplasmic antibodies (ANCA)</subject><subject>Antibodies, Antineutrophil Cytoplasmic - analysis</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Glomerulonephritis</subject><subject>Hematuria</subject><subject>Humans</subject><subject>Idiopathic pulmonary fibrosis</subject><subject>Medical sciences</subject><subject>Microscopic polyangiitis</subject><subject>Middle Aged</subject><subject>Proteinuria</subject><subject>Pulmonary Fibrosis - complications</subject><subject>Pulmonary Fibrosis - diagnosis</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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| subjects | Anti-neutrophilic cytoplasmic antibodies (ANCA) Antibodies, Antineutrophil Cytoplasmic - analysis Biological and medical sciences Female Glomerulonephritis Hematuria Humans Idiopathic pulmonary fibrosis Medical sciences Microscopic polyangiitis Middle Aged Proteinuria Pulmonary Fibrosis - complications Pulmonary Fibrosis - diagnosis Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Vasculitis - complications Vasculitis - diagnosis |
| title | Microscopic Polyangiitis Presenting as Idiopathic Pulmonary Fibrosis: Is Anti-Neutrophilic Cytoplasmic Antibody Testing Indicated? |
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