Pretreating rats with hyperoxia attenuates ischemia-reperfusion injury of the heart

Oxidative stress may precondition the heart. The present study investigated whether hyperoxia elicits a preconditioning-like response. Rats were kept in a hyperoxic (>95% O 2) environment for 60 or 180 minutes. Hearts were Langendorff-perfused immediately or 24 hours after hyperoxia, and exposed...

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Veröffentlicht in:	Life sciences (1973) 2001-02, Vol.68 (14), p.1629-1640
Hauptverfasser:	Tähepôld, Peeter, Valen, Guro, Starkopf, Joel, Kairane, Ceslava, Zilmer, Mihkel, Vaage, Jarle
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Arrhythmias, Cardiac - physiopathology Cardioprotection Heart Function Tests Heat-Shock Proteins - metabolism Hemodynamics - physiology HSP72 Heat-Shock Proteins Hyperoxia Hyperoxia - enzymology Hyperoxia - physiopathology Immunoblotting In Vitro Techniques Ischemia-reperfusion injury Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Lipid Peroxides - metabolism Male Myocardial Infarction - pathology Myocardial Reperfusion Injury - enzymology Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Oxidative stress Oxidative Stress - physiology Oxygen - blood Rats Rats, Sprague-Dawley
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