Inhibition of bacterial RNA polymerase by the cyanobacterial metabolites 12-epi-hapalindole E isonitrile and calothrixin A

Abstract The alkaloid 12-epi-hapalindole E isonitrile, from a cyanobacterial Fischerella species, and the indolophenanthridine calothrixin A, from Calothrix, inhibited Escherichia coli RNA polymerase competitively with respect to ATP, and non-competitively with respect to UTP. The inhibition was dep...

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Veröffentlicht in:	FEMS microbiology letters 2001-03, Vol.196 (2), p.135-139
Hauptverfasser:	Doan, Nga Thanh, Stewart, Peter R., Smith, Geoffrey D.
Format:	Artikel
Sprache:	eng
Schlagworte:	12-epi-hapalindole E isonitrile Addition polymerization Alkaloid alkaloids ATP Bacteriology Bioactive compound Biological and medical sciences Calothrix Calothrixin calothrixin A Cyanobacteria - metabolism Cyanobacterium DNA-directed RNA polymerase DNA-Directed RNA Polymerases - antagonists & inhibitors DNA-Directed RNA Polymerases - metabolism E coli Enzyme Inhibitors - pharmacology Escherichia coli Escherichia coli - enzymology Fischerella Fundamental and applied biological sciences. Psychology Genetics Hapalindole Indole Alkaloids Indoles - chemistry Indoles - pharmacology indolophenanthridines Inhibitors Kinetics Metabolites Microbiology RNA polymerase RNA, Bacterial Substrates Transcription, Genetic UTP
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