The penetration of ceftriaxone and cefamandole into bone, fat and haematoma and relevance of serum protein binding to their penetration into bone
Thirteen patients undergoing total hip replacement were given ceftriaxone 1 g and cefamandole 1 g simultaneously, either immediately or 8 h before surgery. For both agents the concentrations seen in the bone and fat during the operation, and for haematoma fluid ≤24 h after the operation, exceeded th...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 2001-04, Vol.47 (4), p.483-486 |
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| container_title | Journal of antimicrobial chemotherapy |
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| creator | Lovering, A. M. Walsh, T. R. Bannister, G. C. MacGowan, A. P. |
| description | Thirteen patients undergoing total hip replacement were given ceftriaxone 1 g and cefamandole 1 g simultaneously, either immediately or 8 h before surgery. For both agents the concentrations seen in the bone and fat during the operation, and for haematoma fluid ≤24 h after the operation, exceeded the MIC for susceptible staphylococci and would be expected to provide adequate prophylaxis. Although ceftriaxone concentrations in bone and fat were significantly higher than those of cefamandole, after correction for the simultaneous blood concentrations, we were unable to detect any differences in the bone or fat penetration of the two agents. We conclude that there is no evidence that cephalosporins with a lower serum protein binding penetrate bone better than ones with higher serum protein binding. |
| doi_str_mv | 10.1093/jac/47.4.483 |
| format | Article |
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We conclude that there is no evidence that cephalosporins with a lower serum protein binding penetrate bone better than ones with higher serum protein binding.</description><identifier>ISSN: 0305-7453</identifier><identifier>ISSN: 1460-2091</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/47.4.483</identifier><identifier>PMID: 11266427</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adipose Tissue - metabolism ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Blood Proteins - metabolism ; Body Fluids - metabolism ; Bone and Bones - metabolism ; Cefamandole - blood ; Cefamandole - pharmacokinetics ; Ceftriaxone - blood ; Ceftriaxone - pharmacokinetics ; Hematoma - metabolism ; Hip - surgery ; Hip Prosthesis ; Humans ; Medical sciences ; Pharmacology. 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M.</creatorcontrib><creatorcontrib>Walsh, T. R.</creatorcontrib><creatorcontrib>Bannister, G. C.</creatorcontrib><creatorcontrib>MacGowan, A. P.</creatorcontrib><title>The penetration of ceftriaxone and cefamandole into bone, fat and haematoma and relevance of serum protein binding to their penetration into bone</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J. Antimicrob. Chemother</addtitle><description>Thirteen patients undergoing total hip replacement were given ceftriaxone 1 g and cefamandole 1 g simultaneously, either immediately or 8 h before surgery. For both agents the concentrations seen in the bone and fat during the operation, and for haematoma fluid ≤24 h after the operation, exceeded the MIC for susceptible staphylococci and would be expected to provide adequate prophylaxis. Although ceftriaxone concentrations in bone and fat were significantly higher than those of cefamandole, after correction for the simultaneous blood concentrations, we were unable to detect any differences in the bone or fat penetration of the two agents. We conclude that there is no evidence that cephalosporins with a lower serum protein binding penetrate bone better than ones with higher serum protein binding.</description><subject>Adipose Tissue - metabolism</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - metabolism</subject><subject>Body Fluids - metabolism</subject><subject>Bone and Bones - metabolism</subject><subject>Cefamandole - blood</subject><subject>Cefamandole - pharmacokinetics</subject><subject>Ceftriaxone - blood</subject><subject>Ceftriaxone - pharmacokinetics</subject><subject>Hematoma - metabolism</subject><subject>Hip - surgery</subject><subject>Hip Prosthesis</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. 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For both agents the concentrations seen in the bone and fat during the operation, and for haematoma fluid ≤24 h after the operation, exceeded the MIC for susceptible staphylococci and would be expected to provide adequate prophylaxis. Although ceftriaxone concentrations in bone and fat were significantly higher than those of cefamandole, after correction for the simultaneous blood concentrations, we were unable to detect any differences in the bone or fat penetration of the two agents. We conclude that there is no evidence that cephalosporins with a lower serum protein binding penetrate bone better than ones with higher serum protein binding.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>11266427</pmid><doi>10.1093/jac/47.4.483</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Adipose Tissue - metabolism Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Blood Proteins - metabolism Body Fluids - metabolism Bone and Bones - metabolism Cefamandole - blood Cefamandole - pharmacokinetics Ceftriaxone - blood Ceftriaxone - pharmacokinetics Hematoma - metabolism Hip - surgery Hip Prosthesis Humans Medical sciences Pharmacology. Drug treatments Time Factors |
| title | The penetration of ceftriaxone and cefamandole into bone, fat and haematoma and relevance of serum protein binding to their penetration into bone |
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