Bromocriptine-induced dissociation of hyperglycemia and prolactin response to restraint

The present study investigated the effects of immobilization (restraint stress) on rat chronically treated with a D 2 receptor agonist (bromocriptine, 0.4 mg/100 g body weight, injected daily intraperitoneally (ip) for 2 weeks) on plasma glucose, prolactin, and insulin levels. During restraint, the...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2001-02, Vol.68 (2), p.229-233
Hauptverfasser:	Ribeiro-de-Oliveira, Antonio, Guerra, Rachel Menezes, Fóscolo, Rodrigo Bastos, Marubayashi, Umeko, Reis, Adelina Martha dos, Coimbra, Cândido Celso
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Glucose - drug effects Blood Glucose - metabolism Bromocriptine Bromocriptine - pharmacology Catecholaminergic system Dopamine Agonists - pharmacology Fundamental and applied biological sciences. Psychology Hyperglycemia Hyperglycemia - blood Insulin Insulin - blood Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Personality. Affectivity Pharmacology. Drug treatments Prolactin Prolactin - blood Prolactin - drug effects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Restraint, Physical Restraint-stress Stress Stress, Physiological - blood
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Zusammenfassung:	The present study investigated the effects of immobilization (restraint stress) on rat chronically treated with a D 2 receptor agonist (bromocriptine, 0.4 mg/100 g body weight, injected daily intraperitoneally (ip) for 2 weeks) on plasma glucose, prolactin, and insulin levels. During restraint, the plasma prolactin of vehicle-treated (VEH) rats increased rapidly, reaching a peak at 10 min (57.9±8.1 ng/ml, P
ISSN:	0091-3057 1873-5177
DOI:	10.1016/S0091-3057(00)00453-6