Expression of Dominant Negative Form of PAX4 in Human Insulinoma

The paired-homeodomain transcription factor PAX4 is expressed in the early pancreas, but is later restricted to β cells and not expressed in mature islets, suggesting an important role of PAX4 in differentiation and development of pancreatic islet. Here we show that PAX4 mRNA was highly expressed in...

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Veröffentlicht in:	Biochemical and biophysical research communications 2001-03, Vol.282 (1), p.34-40
Hauptverfasser:	Miyamoto, Takahide, Kakizawa, Tomoko, Ichikawa, Kazuo, Nishio, Shinichi, Kajikawa, Shoji, Hashizume, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Cricetinae Gene Expression Regulation Genes, Dominant Homeodomain Proteins - chemistry Homeodomain Proteins - genetics Humans insulin promoter insulinoma Insulinoma - genetics Insulinoma - pathology Molecular Sequence Data Paired Box Transcription Factors pancreatic β-cell PAX4 PAX4 variant RNA Splicing RNA, Messenger - genetics transcription Transcription Factors - chemistry Transcription Factors - genetics Transcription, Genetic Tumor Cells, Cultured
Online-Zugang:	Volltext
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