The pharmacokinetics of once-daily dosing of ceftriaxone in critically ill patients

The aim of this study was to determine the pharmacokinetic profile of the normal recommended dose of ceftriaxone in critically ill patients and to establish whether the current daily dosing recommendation maintains plasma concentrations adequate for antibacterial efficacy. Ceftriaxone at a recommend...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2001-04, Vol.47 (4), p.421-429
Hauptverfasser:	Joynt, G. M., Lipman, J., Gomersall, C. D., Young, R. J., Wong, E. L. Y., Gin, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Ceftriaxone - administration & dosage Ceftriaxone - blood Ceftriaxone - pharmacokinetics Ceftriaxone - therapeutic use Cephalosporins - administration & dosage Cephalosporins - blood Cephalosporins - pharmacokinetics Cephalosporins - therapeutic use Critical Illness Female Half-Life Humans Kidney - physiology Kidney - physiopathology Male Medical sciences Middle Aged Pharmacology. Drug treatments Pneumonia - complications Pneumonia - drug therapy Renal Insufficiency - complications Renal Insufficiency - physiopathology Sepsis - complications Sepsis - drug therapy
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