Increased number of sympathetic neurons with unchanged target organ innervation after postnatal polyamine treatment
Treatment of newborn rats with polyamines from day 2 to day 9 after birth prevented the normal reduction in the number of sympathetic neurons in the superior cervical ganglion. About 40% more neurons prevailed in the ganglion after the polyamine treatment. This increase was paralleled by a comparabl...
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| Veröffentlicht in: | Brain research 1986-08, Vol.28 (2), p.163-168 |
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| creator | Gilad, Gad M. Dornay, Menashe Gilad, Varda H. |
| description | Treatment of newborn rats with polyamines from day 2 to day 9 after birth prevented the normal reduction in the number of sympathetic neurons in the superior cervical ganglion. About 40% more neurons prevailed in the ganglion after the polyamine treatment. This increase was paralleled by a comparable developmental increase in tyrosine hydroxylase activity and a small (17%) increase in choline acetyltransferase activity in the ganglion. However, in the iris, a target organ innervated by the sympathetic neurons, tyrosine hydroxylase activity and [
3H]norepinephrine uptake remained unchanged. The results indicate that the polyamine-induced increase in the number of parent neurons is not accompanied by a change in the number of functional nerve terminals in the target organ. |
| doi_str_mv | 10.1016/0165-3806(86)90019-2 |
| format | Article |
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3H]norepinephrine uptake remained unchanged. The results indicate that the polyamine-induced increase in the number of parent neurons is not accompanied by a change in the number of functional nerve terminals in the target organ.</description><identifier>ISSN: 0165-3806</identifier><identifier>ISSN: 0006-8993</identifier><identifier>DOI: 10.1016/0165-3806(86)90019-2</identifier><identifier>PMID: 2874872</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Animals, Newborn ; Autonomic Fibers, Preganglionic - physiology ; Cell Count - drug effects ; Choline O-Acetyltransferase - metabolism ; development ; Female ; Ganglia, Sympathetic - enzymology ; Ganglia, Sympathetic - growth & development ; Iris - metabolism ; Male ; nerve terminal ; Norepinephrine - metabolism ; polyamine ; Polyamines - pharmacology ; Rats ; Rats, Inbred Strains ; sympathetic neuron ; Tyrosine 3-Monooxygenase - metabolism</subject><ispartof>Brain research, 1986-08, Vol.28 (2), p.163-168</ispartof><rights>1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-c3a2aa5e51a22de6475fdde95517ef5c595c450634972f053a315295d055c91b3</citedby><cites>FETCH-LOGICAL-c456t-c3a2aa5e51a22de6475fdde95517ef5c595c450634972f053a315295d055c91b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2874872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gilad, Gad M.</creatorcontrib><creatorcontrib>Dornay, Menashe</creatorcontrib><creatorcontrib>Gilad, Varda H.</creatorcontrib><title>Increased number of sympathetic neurons with unchanged target organ innervation after postnatal polyamine treatment</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Treatment of newborn rats with polyamines from day 2 to day 9 after birth prevented the normal reduction in the number of sympathetic neurons in the superior cervical ganglion. About 40% more neurons prevailed in the ganglion after the polyamine treatment. This increase was paralleled by a comparable developmental increase in tyrosine hydroxylase activity and a small (17%) increase in choline acetyltransferase activity in the ganglion. However, in the iris, a target organ innervated by the sympathetic neurons, tyrosine hydroxylase activity and [
3H]norepinephrine uptake remained unchanged. The results indicate that the polyamine-induced increase in the number of parent neurons is not accompanied by a change in the number of functional nerve terminals in the target organ.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Autonomic Fibers, Preganglionic - physiology</subject><subject>Cell Count - drug effects</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>development</subject><subject>Female</subject><subject>Ganglia, Sympathetic - enzymology</subject><subject>Ganglia, Sympathetic - growth & development</subject><subject>Iris - metabolism</subject><subject>Male</subject><subject>nerve terminal</subject><subject>Norepinephrine - metabolism</subject><subject>polyamine</subject><subject>Polyamines - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>sympathetic neuron</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><issn>0165-3806</issn><issn>0006-8993</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFr3DAQhXVoSdM0_yABnUJzcCvJHtu6FEpIk0Cgl_YsZuXxroItbSQ5Yf99td0lx_YgJPS-eQPvMXYhxRcpZPu1HKjqXrSf-_ZaCyF1pd6x07fvD-xjSk-iCHUvT9iJ6rum79QpSw_eRsJEA_fLvKLIw8jTbt5i3lB2lntaYvCJv7q84Yu3G_TrAmeMa8o8xDV67ryn-ILZBc9xzMVkG1L2mHEqr2mHs_PEc9mTZ_L5E3s_4pTo_Hifsd8_bn_d3FePP-8ebr4_VraBNle2RoUIBBKVGqhtOhiHgTSA7GgECxoKKNq60Z0aBdRYS1AaBgFgtVzVZ-zq4LuN4XmhlM3skqVpQk9hSaZrte4A4L-gbDrV96IuYHMAbQwpRRrNNroZ485IYfZFmH3iZp-46Vvztwijytjl0X9ZzTS8DR1bKPq3g04ljRdH0STryFsaXCSbzRDcvxf8AQdSm7k</recordid><startdate>19860801</startdate><enddate>19860801</enddate><creator>Gilad, Gad M.</creator><creator>Dornay, Menashe</creator><creator>Gilad, Varda H.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19860801</creationdate><title>Increased number of sympathetic neurons with unchanged target organ innervation after postnatal polyamine treatment</title><author>Gilad, Gad M. ; Dornay, Menashe ; Gilad, Varda H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-c3a2aa5e51a22de6475fdde95517ef5c595c450634972f053a315295d055c91b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Autonomic Fibers, Preganglionic - physiology</topic><topic>Cell Count - drug effects</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>development</topic><topic>Female</topic><topic>Ganglia, Sympathetic - enzymology</topic><topic>Ganglia, Sympathetic - growth & development</topic><topic>Iris - metabolism</topic><topic>Male</topic><topic>nerve terminal</topic><topic>Norepinephrine - metabolism</topic><topic>polyamine</topic><topic>Polyamines - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>sympathetic neuron</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gilad, Gad M.</creatorcontrib><creatorcontrib>Dornay, Menashe</creatorcontrib><creatorcontrib>Gilad, Varda H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gilad, Gad M.</au><au>Dornay, Menashe</au><au>Gilad, Varda H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased number of sympathetic neurons with unchanged target organ innervation after postnatal polyamine treatment</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1986-08-01</date><risdate>1986</risdate><volume>28</volume><issue>2</issue><spage>163</spage><epage>168</epage><pages>163-168</pages><issn>0165-3806</issn><issn>0006-8993</issn><abstract>Treatment of newborn rats with polyamines from day 2 to day 9 after birth prevented the normal reduction in the number of sympathetic neurons in the superior cervical ganglion. About 40% more neurons prevailed in the ganglion after the polyamine treatment. This increase was paralleled by a comparable developmental increase in tyrosine hydroxylase activity and a small (17%) increase in choline acetyltransferase activity in the ganglion. However, in the iris, a target organ innervated by the sympathetic neurons, tyrosine hydroxylase activity and [
3H]norepinephrine uptake remained unchanged. The results indicate that the polyamine-induced increase in the number of parent neurons is not accompanied by a change in the number of functional nerve terminals in the target organ.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>2874872</pmid><doi>10.1016/0165-3806(86)90019-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-3806 |
| ispartof | Brain research, 1986-08, Vol.28 (2), p.163-168 |
| issn | 0165-3806 0006-8993 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76997555 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Alma/SFX Local Collection |
| subjects | Animals Animals, Newborn Autonomic Fibers, Preganglionic - physiology Cell Count - drug effects Choline O-Acetyltransferase - metabolism development Female Ganglia, Sympathetic - enzymology Ganglia, Sympathetic - growth & development Iris - metabolism Male nerve terminal Norepinephrine - metabolism polyamine Polyamines - pharmacology Rats Rats, Inbred Strains sympathetic neuron Tyrosine 3-Monooxygenase - metabolism |
| title | Increased number of sympathetic neurons with unchanged target organ innervation after postnatal polyamine treatment |
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