Isoprinosine effects on interleukin-1 production in acquired immune deficiency syndrome (AIDS)
The in vitro effects of isoprinosine (ISO) on the production of IL-1 in AIDS patients and normal controls were investigated in this study. IL-1 production from adherent cells was measured by an indirect method using EL-4 cells. Five of eleven AIDS patients had depressed IL-1 production. Various conc...
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| Veröffentlicht in: | International journal of immunopharmacology 1986, Vol.8 (4), p.437-441 |
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| container_end_page | 441 |
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| container_issue | 4 |
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| container_title | International journal of immunopharmacology |
| container_volume | 8 |
| creator | Tsang, Kwong Y. Donnelly, R.P. Galbraith, G.M.P. Fudenberg, H.Hugh |
| description | The
in vitro effects of isoprinosine (ISO) on the production of IL-1 in AIDS patients and normal controls were investigated in this study. IL-1 production from adherent cells was measured by an indirect method using EL-4 cells. Five of eleven AIDS patients had depressed IL-1 production. Various concentrations of ISO were used to treat the adherent cells
in vitro and the optimal concentration for stimulating IL-1 production was determined to be 100 μg/ml/10
6 cells. IL-1 production was augmented to normal or to near normal levels in four of five AIDS patients. Our results indicate that depressed immunity seen in some AIDS patients may be partly due to the depressed in IL-1 production and also that ISO can act as an immune potentiation in enhancing the production of this lymphokine
in vitro. |
| doi_str_mv | 10.1016/0192-0561(86)90129-3 |
| format | Article |
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in vitro effects of isoprinosine (ISO) on the production of IL-1 in AIDS patients and normal controls were investigated in this study. IL-1 production from adherent cells was measured by an indirect method using EL-4 cells. Five of eleven AIDS patients had depressed IL-1 production. Various concentrations of ISO were used to treat the adherent cells
in vitro and the optimal concentration for stimulating IL-1 production was determined to be 100 μg/ml/10
6 cells. IL-1 production was augmented to normal or to near normal levels in four of five AIDS patients. Our results indicate that depressed immunity seen in some AIDS patients may be partly due to the depressed in IL-1 production and also that ISO can act as an immune potentiation in enhancing the production of this lymphokine
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in vitro effects of isoprinosine (ISO) on the production of IL-1 in AIDS patients and normal controls were investigated in this study. IL-1 production from adherent cells was measured by an indirect method using EL-4 cells. Five of eleven AIDS patients had depressed IL-1 production. Various concentrations of ISO were used to treat the adherent cells
in vitro and the optimal concentration for stimulating IL-1 production was determined to be 100 μg/ml/10
6 cells. IL-1 production was augmented to normal or to near normal levels in four of five AIDS patients. Our results indicate that depressed immunity seen in some AIDS patients may be partly due to the depressed in IL-1 production and also that ISO can act as an immune potentiation in enhancing the production of this lymphokine
in vitro.</description><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Immunomodulators</subject><subject>In Vitro Techniques</subject><subject>Inosine - analogs & derivatives</subject><subject>Inosine Pranobex - pharmacology</subject><subject>Interleukin-1 - biosynthesis</subject><subject>Interleukin-2 - analysis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>T-Lymphocytes - classification</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - immunology</subject><issn>0192-0561</issn><issn>1879-3495</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVoSTdp_0EKPpSSHNzqy2PpEghp0i4EemhyrZClMai15USyC_vvq_1gjzlJ8D7vMPMQcsHoF0YZfKVM85o2wC4VXGnKuK7FCVkx1ZaP1M0bsjoi78hZzn8opQ0DfkpOueStBLYiv9d5ek4hTjlErLDv0c25mmIV4oxpwOVviDWrntPkFzeHXVBZ97KEhL4K47iUmsc-uIDRbaq8iT5NI1aXN-tvv67ek7e9HTJ-OLzn5On-7vH2R_3w8_v69uahdkLBXDMBvmscBdE5xxXrFG2w0VxbELyTKLhFaxsNlKNsGbeO-U5JUJIrEJSKc_J5P7cs-rJgns0YssNhsBGnJZsWtG45QAHlHnRpyjlhb8r1o00bw6jZajVbZ2brzCgwO61GlNrHw_ylG9EfSwePJf90yG12duiTjS7kI6baRoCUBbveY1hc_AuYTN55Q190utn4Kby-x3-aaJLO</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Tsang, Kwong Y.</creator><creator>Donnelly, R.P.</creator><creator>Galbraith, G.M.P.</creator><creator>Fudenberg, H.Hugh</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>Isoprinosine effects on interleukin-1 production in acquired immune deficiency syndrome (AIDS)</title><author>Tsang, Kwong Y. ; Donnelly, R.P. ; Galbraith, G.M.P. ; Fudenberg, H.Hugh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-136db5c063bcc281b805e5929a632b4e32aeaa59602e4712ac1db846842863003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Acquired Immunodeficiency Syndrome - immunology</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Humans</topic><topic>Immunomodulators</topic><topic>In Vitro Techniques</topic><topic>Inosine - analogs & derivatives</topic><topic>Inosine Pranobex - pharmacology</topic><topic>Interleukin-1 - biosynthesis</topic><topic>Interleukin-2 - analysis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>T-Lymphocytes - classification</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsang, Kwong Y.</creatorcontrib><creatorcontrib>Donnelly, R.P.</creatorcontrib><creatorcontrib>Galbraith, G.M.P.</creatorcontrib><creatorcontrib>Fudenberg, H.Hugh</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsang, Kwong Y.</au><au>Donnelly, R.P.</au><au>Galbraith, G.M.P.</au><au>Fudenberg, H.Hugh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isoprinosine effects on interleukin-1 production in acquired immune deficiency syndrome (AIDS)</atitle><jtitle>International journal of immunopharmacology</jtitle><addtitle>Int J Immunopharmacol</addtitle><date>1986</date><risdate>1986</risdate><volume>8</volume><issue>4</issue><spage>437</spage><epage>441</epage><pages>437-441</pages><issn>0192-0561</issn><eissn>1879-3495</eissn><coden>IJIMDS</coden><abstract>The
in vitro effects of isoprinosine (ISO) on the production of IL-1 in AIDS patients and normal controls were investigated in this study. IL-1 production from adherent cells was measured by an indirect method using EL-4 cells. Five of eleven AIDS patients had depressed IL-1 production. Various concentrations of ISO were used to treat the adherent cells
in vitro and the optimal concentration for stimulating IL-1 production was determined to be 100 μg/ml/10
6 cells. IL-1 production was augmented to normal or to near normal levels in four of five AIDS patients. Our results indicate that depressed immunity seen in some AIDS patients may be partly due to the depressed in IL-1 production and also that ISO can act as an immune potentiation in enhancing the production of this lymphokine
in vitro.</abstract><cop>Oxford</cop><pub>Elsevier Science</pub><pmid>2427461</pmid><doi>10.1016/0192-0561(86)90129-3</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0192-0561 |
| ispartof | International journal of immunopharmacology, 1986, Vol.8 (4), p.437-441 |
| issn | 0192-0561 1879-3495 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Acquired Immunodeficiency Syndrome - immunology AIDS/HIV Biological and medical sciences Female Humans Immunomodulators In Vitro Techniques Inosine - analogs & derivatives Inosine Pranobex - pharmacology Interleukin-1 - biosynthesis Interleukin-2 - analysis Male Medical sciences Pharmacology. Drug treatments T-Lymphocytes - classification T-Lymphocytes - drug effects T-Lymphocytes - immunology |
| title | Isoprinosine effects on interleukin-1 production in acquired immune deficiency syndrome (AIDS) |
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