Enalapril reduces the catecholamine response to exercise in patients with heart failure
Increased sympathetic activity occurs in congestive heart failure and may have deleterious effects. To examine the effects of angiotensin converting enzyme (ACE) inhibition on sympathetic activity in heart failure, the noradrenaline response to exercise was measured in 18 patients given enalapril or...
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| Veröffentlicht in: | European journal of clinical pharmacology 1986-01, Vol.30 (4), p.485-487 |
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| container_end_page | 487 |
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| container_title | European journal of clinical pharmacology |
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| creator | MCGRATH, B. P ARNOLDA, L. F |
| description | Increased sympathetic activity occurs in congestive heart failure and may have deleterious effects. To examine the effects of angiotensin converting enzyme (ACE) inhibition on sympathetic activity in heart failure, the noradrenaline response to exercise was measured in 18 patients given enalapril or placebo in double-blind trial. The plasma noradrenaline response to graded exercise was significantly reduced after 4 weeks on active treatment but was unchanged by placebo treatment. The rate-pressure product at maximal exercise was significantly reduced after 4 weeks in the enalapril group but unchanged in the placebo group. These results suggest that ACE inhibition reduces sympathetic activity in patients with heart failure. |
| doi_str_mv | 10.1007/BF00607965 |
| format | Article |
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P ; ARNOLDA, L. F</creator><creatorcontrib>MCGRATH, B. P ; ARNOLDA, L. F</creatorcontrib><description>Increased sympathetic activity occurs in congestive heart failure and may have deleterious effects. To examine the effects of angiotensin converting enzyme (ACE) inhibition on sympathetic activity in heart failure, the noradrenaline response to exercise was measured in 18 patients given enalapril or placebo in double-blind trial. The plasma noradrenaline response to graded exercise was significantly reduced after 4 weeks on active treatment but was unchanged by placebo treatment. The rate-pressure product at maximal exercise was significantly reduced after 4 weeks in the enalapril group but unchanged in the placebo group. These results suggest that ACE inhibition reduces sympathetic activity in patients with heart failure.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00607965</identifier><identifier>PMID: 3017723</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Aged ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiovascular system ; Double-Blind Method ; Enalapril - therapeutic use ; Female ; Heart Failure - blood ; Heart Failure - drug therapy ; Heart Rate - drug effects ; Humans ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Norepinephrine - blood ; Pharmacology. 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P</creatorcontrib><creatorcontrib>ARNOLDA, L. F</creatorcontrib><title>Enalapril reduces the catecholamine response to exercise in patients with heart failure</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>Increased sympathetic activity occurs in congestive heart failure and may have deleterious effects. To examine the effects of angiotensin converting enzyme (ACE) inhibition on sympathetic activity in heart failure, the noradrenaline response to exercise was measured in 18 patients given enalapril or placebo in double-blind trial. The plasma noradrenaline response to graded exercise was significantly reduced after 4 weeks on active treatment but was unchanged by placebo treatment. The rate-pressure product at maximal exercise was significantly reduced after 4 weeks in the enalapril group but unchanged in the placebo group. These results suggest that ACE inhibition reduces sympathetic activity in patients with heart failure.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular system</subject><subject>Double-Blind Method</subject><subject>Enalapril - therapeutic use</subject><subject>Female</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - drug therapy</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Norepinephrine - blood</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Physical Exertion - drug effects</topic><topic>Random Allocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MCGRATH, B. P</creatorcontrib><creatorcontrib>ARNOLDA, L. F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MCGRATH, B. P</au><au>ARNOLDA, L. 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| ispartof | European journal of clinical pharmacology, 1986-01, Vol.30 (4), p.485-487 |
| issn | 0031-6970 1432-1041 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Double-Blind Method Enalapril - therapeutic use Female Heart Failure - blood Heart Failure - drug therapy Heart Rate - drug effects Humans Male Medical sciences Middle Aged Miscellaneous Norepinephrine - blood Pharmacology. Drug treatments Physical Exertion - drug effects Random Allocation |
| title | Enalapril reduces the catecholamine response to exercise in patients with heart failure |
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