Composition of the lymphoid cell populations from omental milky spots during the immune response in C57BL/Ka mice

The lymphoid cell composition of milky spots was analyzed in unprimed mice before and after i.p. immunization with sheep red blood cells. Milky spots contained surface immunoglobulin‐positive B lymphocytes, and T cells of the helper and cytotoxic phenotype. After secondary antigen challenge (a) the...

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Veröffentlicht in:	European journal of immunology 1986, Vol.16 (8), p.1029-1032
Hauptverfasser:	Paper, Short, Dux, Kazimir, Rouse, Robert V., Kyewski, Bruno
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Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals B-Lymphocytes - classification Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Lymphocytes - classification Mice Mice, Inbred Strains Omentum - immunology Organs and cells involved in the immune response T-Lymphocytes - classification
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container_title	European journal of immunology
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creator	Paper, Short Dux, Kazimir Rouse, Robert V. Kyewski, Bruno
description	The lymphoid cell composition of milky spots was analyzed in unprimed mice before and after i.p. immunization with sheep red blood cells. Milky spots contained surface immunoglobulin‐positive B lymphocytes, and T cells of the helper and cytotoxic phenotype. After secondary antigen challenge (a) the number of lymphocytes increased up to 40‐fold, (b) B and T cells were found to segregate into distinct areas in situ, and (c) lymphocytes were found to associate with I‐A‐negative stromal cells in vivo. These findings qualify milky spots as a peripheral lymphoid organ exhibiting a remarkable change in number and composition of lymphocytes in response to a local antigen stimulus.
doi_str_mv	10.1002/eji.1830160828
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Milky spots contained surface immunoglobulin‐positive B lymphocytes, and T cells of the helper and cytotoxic phenotype. After secondary antigen challenge (a) the number of lymphocytes increased up to 40‐fold, (b) B and T cells were found to segregate into distinct areas in situ, and (c) lymphocytes were found to associate with I‐A‐negative stromal cells in vivo. These findings qualify milky spots as a peripheral lymphoid organ exhibiting a remarkable change in number and composition of lymphocytes in response to a local antigen stimulus.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830160828</identifier><identifier>PMID: 3488910</identifier><identifier>CODEN: EJIMAF</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Analysis of the immune response. 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Milky spots contained surface immunoglobulin‐positive B lymphocytes, and T cells of the helper and cytotoxic phenotype. After secondary antigen challenge (a) the number of lymphocytes increased up to 40‐fold, (b) B and T cells were found to segregate into distinct areas in situ, and (c) lymphocytes were found to associate with I‐A‐negative stromal cells in vivo. These findings qualify milky spots as a peripheral lymphoid organ exhibiting a remarkable change in number and composition of lymphocytes in response to a local antigen stimulus.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>B-Lymphocytes - classification</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Immunobiology</subject><subject>Lymphocytes - classification</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Omentum - immunology</subject><subject>Organs and cells involved in the immune response</subject><subject>T-Lymphocytes - classification</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1P3DAUxC3UCraUKzckH6resryXxFn7SFe0ha7EhZ4jJ7bBYMfBToT2v8fbXdHeevLH_Gb8PIScIywRoLzUT3aJvAJsgJf8iCyQlVjUWOMHsgDAuigFhxPyKaUnABANE8fkuKo5FwgL8rIOfgzJTjYMNBg6PWrqtn58DFbRXjtHxzDOTu70RE0Mngavh0k66q173tI0hilRNUc7PPxxW-_nQdOoszKkfB7omq2-bS5_yWzp9Wfy0UiX9NlhPSW_v1_fr38Wm7sfN-urTdHXFeMFGo1CSSMaJSSy2nScsUoqqXrBBOabssGuVKU0wIGJjgvVlf3KYA15C9Up-brPHWN4mXWaWm_T7kdy0GFO7aoRolmhyOByD_YxpBS1acdovYzbFqHdddzmjtu_HWfDxSF57rxW7_ih1Kx_Oegy9dKZKIfepncsT1txvosRe-zVOr39z6Pt9e3NPyO8AayTlZU</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Paper, Short</creator><creator>Dux, Kazimir</creator><creator>Rouse, Robert V.</creator><creator>Kyewski, Bruno</creator><general>WILEY‐VCH Verlag GmbH</general><general>Wiley-VCH</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>Composition of the lymphoid cell populations from omental milky spots during the immune response in C57BL/Ka mice</title><author>Paper, Short ; Dux, Kazimir ; Rouse, Robert V. ; Kyewski, Bruno</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4358-1fe19daf96d9a154fb8553adadc9591154261b2d2af08059b89db2c7f14089d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>B-Lymphocytes - classification</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Immunobiology</topic><topic>Lymphocytes - classification</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Omentum - immunology</topic><topic>Organs and cells involved in the immune response</topic><topic>T-Lymphocytes - classification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paper, Short</creatorcontrib><creatorcontrib>Dux, Kazimir</creatorcontrib><creatorcontrib>Rouse, Robert V.</creatorcontrib><creatorcontrib>Kyewski, Bruno</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paper, Short</au><au>Dux, Kazimir</au><au>Rouse, Robert V.</au><au>Kyewski, Bruno</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Composition of the lymphoid cell populations from omental milky spots during the immune response in C57BL/Ka mice</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1986</date><risdate>1986</risdate><volume>16</volume><issue>8</issue><spage>1029</spage><epage>1032</epage><pages>1029-1032</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><coden>EJIMAF</coden><abstract>The lymphoid cell composition of milky spots was analyzed in unprimed mice before and after i.p. immunization with sheep red blood cells. Milky spots contained surface immunoglobulin‐positive B lymphocytes, and T cells of the helper and cytotoxic phenotype. After secondary antigen challenge (a) the number of lymphocytes increased up to 40‐fold, (b) B and T cells were found to segregate into distinct areas in situ, and (c) lymphocytes were found to associate with I‐A‐negative stromal cells in vivo. These findings qualify milky spots as a peripheral lymphoid organ exhibiting a remarkable change in number and composition of lymphocytes in response to a local antigen stimulus.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>3488910</pmid><doi>10.1002/eji.1830160828</doi><tpages>4</tpages></addata></record>
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subjects	Analysis of the immune response. Humoral and cellular immunity Animals B-Lymphocytes - classification Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Lymphocytes - classification Mice Mice, Inbred Strains Omentum - immunology Organs and cells involved in the immune response T-Lymphocytes - classification
title	Composition of the lymphoid cell populations from omental milky spots during the immune response in C57BL/Ka mice
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