Intrarenal synthesis of complement
Intrarenal synthesis of complement. During the past decade, research has shown that the kidney has the capacity to synthesize most of the activation pathway components of the complement cascade. As well as implying physiological roles in local clearance of immune complexes and defense against invasi...
Gespeichert in:
| Veröffentlicht in: | Kidney international 2001-04, Vol.59 (4), p.1227-1235 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1235 |
|---|---|
| container_issue | 4 |
| container_start_page | 1227 |
| container_title | Kidney international |
| container_volume | 59 |
| creator | Zhou, Wuding Marsh, James E. Sacks, Steven H. |
| description | Intrarenal synthesis of complement. During the past decade, research has shown that the kidney has the capacity to synthesize most of the activation pathway components of the complement cascade. As well as implying physiological roles in local clearance of immune complexes and defense against invasive organisms, an increasing amount of evidence indicates that the intrarenal synthesis of complement makes an important contribution in the pathogenesis of renal injury. Here we review this evidence and present a case for more definitive investigation of these functions. |
| doi_str_mv | 10.1046/j.1523-1755.2001.0590041227.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76990700</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0085253815475945</els_id><sourcerecordid>984983291</sourcerecordid><originalsourceid>FETCH-LOGICAL-c495t-57dd22a9aea0b92e67c929d2c8c48beda4ea4369d4faaf95c07d11527764bf373</originalsourceid><addsrcrecordid>eNqNkEtLAzEQgIMoWqt_QYqit10nyWazOXgQ8VEoeNFzSJNZ3GUfNdmV-u9NaangydMwzDevj5BrCimFLL-tUyoYT6gUImUANAWhADLKmEzXB2Syrx6SCUAhEiZ4cUJOQ6gh5orDMTmhlOXACzYhl_Nu8MZjZ5pZ-O6GDwxVmPXlzPbtqsEWu-GMHJWmCXi-i1Py_vT49vCSLF6f5w_3i8RmSgyJkM4xZpRBA0vFMJdWMeWYLWxWLNGZDE3Gc-Wy0phSCQvS0XitlHm2LLnkU3Kznbvy_eeIYdBtFSw2jemwH4OWuVIgASJ4-Qes-9HHD4JmFKIJzlmE7raQ9X0IHku98lVr_LemoDcmda03rvTGld6Y1L8m9Tr2X-yWjMsW3W_3Tl0ErnaACdY0pTedrcKeU6xQRR6p5y2F0dxXhV4HW2Fn0VUe7aBdX_3zoB9BVZEe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>210122332</pqid></control><display><type>article</type><title>Intrarenal synthesis of complement</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>ProQuest Central UK/Ireland</source><source>Alma/SFX Local Collection</source><creator>Zhou, Wuding ; Marsh, James E. ; Sacks, Steven H.</creator><creatorcontrib>Zhou, Wuding ; Marsh, James E. ; Sacks, Steven H.</creatorcontrib><description>Intrarenal synthesis of complement. During the past decade, research has shown that the kidney has the capacity to synthesize most of the activation pathway components of the complement cascade. As well as implying physiological roles in local clearance of immune complexes and defense against invasive organisms, an increasing amount of evidence indicates that the intrarenal synthesis of complement makes an important contribution in the pathogenesis of renal injury. Here we review this evidence and present a case for more definitive investigation of these functions.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1046/j.1523-1755.2001.0590041227.x</identifier><identifier>PMID: 11260382</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; complement cascade ; Complement System Proteins - biosynthesis ; gene expression of complement ; Glomerulonephritis ; Humans ; immune complexes ; Kidney - metabolism ; Kidney Diseases - etiology ; Kidney Transplantation - immunology ; Medical sciences ; Nephritis - etiology ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; pathogenesis of renal disease ; protein synthesis ; renal complement system</subject><ispartof>Kidney international, 2001-04, Vol.59 (4), p.1227-1235</ispartof><rights>2001 International Society of Nephrology</rights><rights>2001 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Apr 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-57dd22a9aea0b92e67c929d2c8c48beda4ea4369d4faaf95c07d11527764bf373</citedby><cites>FETCH-LOGICAL-c495t-57dd22a9aea0b92e67c929d2c8c48beda4ea4369d4faaf95c07d11527764bf373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/210122332?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,64362,64364,64366,72216</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=928986$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11260382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Wuding</creatorcontrib><creatorcontrib>Marsh, James E.</creatorcontrib><creatorcontrib>Sacks, Steven H.</creatorcontrib><title>Intrarenal synthesis of complement</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Intrarenal synthesis of complement. During the past decade, research has shown that the kidney has the capacity to synthesize most of the activation pathway components of the complement cascade. As well as implying physiological roles in local clearance of immune complexes and defense against invasive organisms, an increasing amount of evidence indicates that the intrarenal synthesis of complement makes an important contribution in the pathogenesis of renal injury. Here we review this evidence and present a case for more definitive investigation of these functions.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>complement cascade</subject><subject>Complement System Proteins - biosynthesis</subject><subject>gene expression of complement</subject><subject>Glomerulonephritis</subject><subject>Humans</subject><subject>immune complexes</subject><subject>Kidney - metabolism</subject><subject>Kidney Diseases - etiology</subject><subject>Kidney Transplantation - immunology</subject><subject>Medical sciences</subject><subject>Nephritis - etiology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>pathogenesis of renal disease</subject><subject>protein synthesis</subject><subject>renal complement system</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkEtLAzEQgIMoWqt_QYqit10nyWazOXgQ8VEoeNFzSJNZ3GUfNdmV-u9NaangydMwzDevj5BrCimFLL-tUyoYT6gUImUANAWhADLKmEzXB2Syrx6SCUAhEiZ4cUJOQ6gh5orDMTmhlOXACzYhl_Nu8MZjZ5pZ-O6GDwxVmPXlzPbtqsEWu-GMHJWmCXi-i1Py_vT49vCSLF6f5w_3i8RmSgyJkM4xZpRBA0vFMJdWMeWYLWxWLNGZDE3Gc-Wy0phSCQvS0XitlHm2LLnkU3Kznbvy_eeIYdBtFSw2jemwH4OWuVIgASJ4-Qes-9HHD4JmFKIJzlmE7raQ9X0IHku98lVr_LemoDcmda03rvTGld6Y1L8m9Tr2X-yWjMsW3W_3Tl0ErnaACdY0pTedrcKeU6xQRR6p5y2F0dxXhV4HW2Fn0VUe7aBdX_3zoB9BVZEe</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Zhou, Wuding</creator><creator>Marsh, James E.</creator><creator>Sacks, Steven H.</creator><general>Elsevier Inc</general><general>Nature Publishing</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Intrarenal synthesis of complement</title><author>Zhou, Wuding ; Marsh, James E. ; Sacks, Steven H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-57dd22a9aea0b92e67c929d2c8c48beda4ea4369d4faaf95c07d11527764bf373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>complement cascade</topic><topic>Complement System Proteins - biosynthesis</topic><topic>gene expression of complement</topic><topic>Glomerulonephritis</topic><topic>Humans</topic><topic>immune complexes</topic><topic>Kidney - metabolism</topic><topic>Kidney Diseases - etiology</topic><topic>Kidney Transplantation - immunology</topic><topic>Medical sciences</topic><topic>Nephritis - etiology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>pathogenesis of renal disease</topic><topic>protein synthesis</topic><topic>renal complement system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Wuding</creatorcontrib><creatorcontrib>Marsh, James E.</creatorcontrib><creatorcontrib>Sacks, Steven H.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Wuding</au><au>Marsh, James E.</au><au>Sacks, Steven H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrarenal synthesis of complement</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>59</volume><issue>4</issue><spage>1227</spage><epage>1235</epage><pages>1227-1235</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>Intrarenal synthesis of complement. During the past decade, research has shown that the kidney has the capacity to synthesize most of the activation pathway components of the complement cascade. As well as implying physiological roles in local clearance of immune complexes and defense against invasive organisms, an increasing amount of evidence indicates that the intrarenal synthesis of complement makes an important contribution in the pathogenesis of renal injury. Here we review this evidence and present a case for more definitive investigation of these functions.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11260382</pmid><doi>10.1046/j.1523-1755.2001.0590041227.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0085-2538 |
| ispartof | Kidney international, 2001-04, Vol.59 (4), p.1227-1235 |
| issn | 0085-2538 1523-1755 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76990700 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences complement cascade Complement System Proteins - biosynthesis gene expression of complement Glomerulonephritis Humans immune complexes Kidney - metabolism Kidney Diseases - etiology Kidney Transplantation - immunology Medical sciences Nephritis - etiology Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure pathogenesis of renal disease protein synthesis renal complement system |
| title | Intrarenal synthesis of complement |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T11%3A44%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intrarenal%20synthesis%20of%20complement&rft.jtitle=Kidney%20international&rft.au=Zhou,%20Wuding&rft.date=2001-04-01&rft.volume=59&rft.issue=4&rft.spage=1227&rft.epage=1235&rft.pages=1227-1235&rft.issn=0085-2538&rft.eissn=1523-1755&rft.coden=KDYIA5&rft_id=info:doi/10.1046/j.1523-1755.2001.0590041227.x&rft_dat=%3Cproquest_cross%3E984983291%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=210122332&rft_id=info:pmid/11260382&rft_els_id=S0085253815475945&rfr_iscdi=true |