Alternative versus classical macrophage activation during experimental African trypanosomosis

The type I/type II cytokine balance may influence the development of different subsets of suppressive macrophages, i.e., classically activated macrophages (caMφ, type I) versus alternatively activated macrophages (aaMφ, type II). Recently, we showed that although mice infected with phospholipase C‐d...

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Veröffentlicht in:	Journal of leukocyte biology 2001-03, Vol.69 (3), p.387-396
Hauptverfasser:	Namangala, Boniface, De Baetselier, Patrick, Noël, Wim, Brys, Lea, Beschin, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antigen presentation Antigen Presentation - immunology Arginase - blood Ascitic Fluid - metabolism Ascitic Fluid - pathology Concanavalin A - pharmacology Enterotoxins - immunology Enterotoxins - pharmacology Epitopes, T-Lymphocyte - immunology Female immunosuppression Interferon-gamma - biosynthesis Interleukins - biosynthesis Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Macrophage Activation - drug effects Macrophage Activation - immunology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Mice Mice, Inbred BALB C Mitogens - pharmacology Muramidase - immunology Muramidase - pharmacology Nitric Oxide - blood Phenotype phospholipase C Superantigens - immunology Superantigens - pharmacology T-Lymphocytes - drug effects T-Lymphocytes - immunology Trypanosoma brucei brucei Trypanosoma brucei brucei - enzymology Trypanosoma brucei brucei - genetics trypanosome infection Trypanosomiasis, African - blood Trypanosomiasis, African - immunology Type C Phospholipases - deficiency Type C Phospholipases - genetics
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