Synthesis and Stereochemical Elucidation of a 14-Membered Ring Phosphonate
We report the synthesis and stereochemical elucidation of a 14-membered ring phosphonate. The key step in the synthesis of the macrolide phosphonate was the cyclization of the acyclic precursor using the Mitsunobu reaction, a mild reaction for the preparation of mixed phosphonates.
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| Veröffentlicht in: | Organic letters 2001-03, Vol.3 (5), p.643-646 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | We report the synthesis and stereochemical elucidation of a 14-membered ring phosphonate. The key step in the synthesis of the macrolide phosphonate was the cyclization of the acyclic precursor using the Mitsunobu reaction, a mild reaction for the preparation of mixed phosphonates. |
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| ISSN: | 1523-7060 1523-7052 |
| DOI: | 10.1021/ol006422v |