Direct inhibition of expressed cardiac L- and T-type calcium channels by IgG from mothers whose children have congenital heart block

Congenital heart block (CHB) is a disease that affects the offspring of mothers with autoimmune diseases. We recently reported that maternal sera containing antibodies against SSA/Ro and SSB/La ribonucleoproteins (positive IgG) inhibited L-type Ca current in isolated cardiac myocytes and induced sin...

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