LPS induction of gene expression in human monocytes

Lipopolysaccharide (LPS [endotoxin]) is the principal component of the outer membrane of Gram-negative bacteria. Recent studies have elucidated how LPS is recognized by monocytes and macrophages of the innate immune system. Human monocytes are exquisitely sensitive to LPS and respond by expressing m...

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Veröffentlicht in:	Cellular Signalling 2001-02, Vol.13 (2), p.85-94
Hauptverfasser:	Guha, Mausumee, Mackman, Nigel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Surface - metabolism CD14 Drosophila Proteins Endotoxin Humans LBP Lipopolysaccharide Receptors - biosynthesis Lipopolysaccharides - metabolism Lymphocyte Antigen 96 MAP Kinase Signaling System MAPK Membrane Glycoproteins - metabolism Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinases - metabolism Models, Biological Monocytes Monocytes - metabolism NF-kappa B - metabolism NF-κB p38 Mitogen-Activated Protein Kinases Protein Binding Receptors, Cell Surface - metabolism Sepsis - metabolism Septic shock Signal Transduction TLR4 Toll-Like Receptor 4 Toll-Like Receptors
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