Rescue of Contractile Parameters and Myocyte Hypertrophy in Calsequestrin Overexpressing Myocardium by Phospholamban Ablation

Cardiac-specific overexpression of murine cardiac calsequestrin results in depressed cardiac contractile parameters, low Ca2+-induced Ca2+ release from sarcoplasmic reticulum (SR) and cardiac hypertrophy in transgenic mice. To test the hypothesis that inhibition of phospholamban activity may rescue...

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Veröffentlicht in:	The Journal of biological chemistry 2001-03, Vol.276 (12), p.9392-9399
Hauptverfasser:	Sato, Yoji, Kiriazis, Helen, Yatani, Atsuko, Schmidt, Albrecht G., Hahn, Harvey, Ferguson, Donald G., Sako, Hidenori, Mitarai, Sayaka, Honda, Ritsu, Mesnard-Rouiller, Laurence, Frank, Konrad F., Beyermann, Beate, Wu, Guangyu, Fujimori, Kannosuke, Dorn, Gerald W., Kranias, Evangelia G.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology Animals Atrial Natriuretic Factor - biosynthesis Calcium-Binding Proteins - genetics Calcium-Binding Proteins - physiology Calsequestrin Calsequestrin - metabolism Cardiomegaly Heart - drug effects Immunohistochemistry Isoproterenol - pharmacology Mice Mice, Knockout Myocardial Contraction Myocardium - cytology Myocardium - metabolism Patch-Clamp Techniques Sarcoplasmic Reticulum - metabolism
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