An RNA Ligase Essential for RNA Editing and Survival of the Bloodstream Form of Trypanosoma brucei

RNA editing in trypanosomes occurs by a series of enzymatic steps that are catalyzed by a macromolecular complex. The TbMP52 protein is shown to be a component of this complex, to have RNA ligase activity, and to be one of two adenylatable proteins in the complex. Regulated repression of TbMP52 bloc...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2001-03, Vol.291 (5511), p.2159-2162
Hauptverfasser:	Schnaufer, Achim, Panigrahi, Aswini K., Panicucci, Brian, Igo, Robert P., Salavati, Reza, Stuart, Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence Animals Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences Cell growth DNA Down-Regulation Editing Enzymes Fundamental and applied biological sciences. Psychology Gene Targeting Genes, Protozoan Infections Ligases - chemistry Ligases - genetics Ligases - metabolism Messenger RNA Mice Mice, Inbred C57BL Mitochondrial DNA Molecular Sequence Data Parasitemia - parasitology Parasites Phosphorus-Oxygen Lyases - chemistry Phosphorus-Oxygen Lyases - genetics Phosphorus-Oxygen Lyases - metabolism Proteins Protozoa Protozoan Proteins - chemistry Protozoan Proteins - genetics Protozoan Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA Editing RNA ligase RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Protozoan - genetics RNA, Protozoan - metabolism Sequence Alignment TbMP52 protein Transfection Transfer RNA Trypanosoma brucei Trypanosoma brucei brucei - enzymology Trypanosoma brucei brucei - genetics Trypanosoma brucei brucei - growth & development Trypanosomiasis, African - drug therapy Trypanosomiasis, African - parasitology
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