Chronic effects of clonazepam, phenytoin, ethosuximide, and valproic acid on learning in pigeons as assayed by a repeated acquisition procedure
The acute and chronic effects of the antiepileptic drugs clonazepam (0.06, 0.13, and 0.25 mg/kg), phenytoin (2.5, 5, 7.5 mg/kg), ethosuximide (40, 80, and 120 mg/kg), and valproic acid (40, 80, and 120 mg/kg) were evaluated in pigeons responding under a repeated acquisition procedure. At certain dos...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1986-06, Vol.24 (6), p.1583-1586 |
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| container_issue | 6 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Poling, Alan Blakely, Elbert White, Wesley Picker, Mitchell |
| description | The acute and chronic effects of the antiepileptic drugs clonazepam (0.06, 0.13, and 0.25 mg/kg), phenytoin (2.5, 5, 7.5 mg/kg), ethosuximide (40, 80, and 120 mg/kg), and valproic acid (40, 80, and 120 mg/kg) were evaluated in pigeons responding under a repeated acquisition procedure. At certain doses, acute administrations of all drugs impaired learning (i.e., increased errors) and reduced rate of responding. Appreciable tolerance developed to these effects with chronic exposure, although the physiological mechanism responsible for this outcome is unknown. |
| doi_str_mv | 10.1016/0091-3057(86)90489-2 |
| format | Article |
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At certain doses, acute administrations of all drugs impaired learning (i.e., increased errors) and reduced rate of responding. Appreciable tolerance developed to these effects with chronic exposure, although the physiological mechanism responsible for this outcome is unknown.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(86)90489-2</identifier><identifier>PMID: 3090564</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Anticonvulsant drugs ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Benzodiazepinones - pharmacology ; Biological and medical sciences ; Clonazepam ; Clonazepam - pharmacology ; Columbidae ; Dose-Response Relationship, Drug ; Drug Tolerance ; Ethosuximide ; Ethosuximide - pharmacology ; Learning - drug effects ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Phenytoin ; Phenytoin - pharmacology ; Pigeons ; Repeated acquisition procedure ; Tolerance ; Valproic acid ; Valproic Acid - pharmacology</subject><ispartof>Pharmacology, biochemistry and behavior, 1986-06, Vol.24 (6), p.1583-1586</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-311d6e5f462116000ad2e8f5371d103d90ffb4ae949925ceb03a6316d3d8dbd3</citedby><cites>FETCH-LOGICAL-c386t-311d6e5f462116000ad2e8f5371d103d90ffb4ae949925ceb03a6316d3d8dbd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0091305786904892$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8111525$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3090564$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poling, Alan</creatorcontrib><creatorcontrib>Blakely, Elbert</creatorcontrib><creatorcontrib>White, Wesley</creatorcontrib><creatorcontrib>Picker, Mitchell</creatorcontrib><title>Chronic effects of clonazepam, phenytoin, ethosuximide, and valproic acid on learning in pigeons as assayed by a repeated acquisition procedure</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>The acute and chronic effects of the antiepileptic drugs clonazepam (0.06, 0.13, and 0.25 mg/kg), phenytoin (2.5, 5, 7.5 mg/kg), ethosuximide (40, 80, and 120 mg/kg), and valproic acid (40, 80, and 120 mg/kg) were evaluated in pigeons responding under a repeated acquisition procedure. At certain doses, acute administrations of all drugs impaired learning (i.e., increased errors) and reduced rate of responding. Appreciable tolerance developed to these effects with chronic exposure, although the physiological mechanism responsible for this outcome is unknown.</description><subject>Animals</subject><subject>Anticonvulsant drugs</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Benzodiazepinones - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Clonazepam</subject><subject>Clonazepam - pharmacology</subject><subject>Columbidae</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Tolerance</subject><subject>Ethosuximide</subject><subject>Ethosuximide - pharmacology</subject><subject>Learning - drug effects</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenytoin</subject><subject>Phenytoin - pharmacology</subject><subject>Pigeons</subject><subject>Repeated acquisition procedure</subject><subject>Tolerance</subject><subject>Valproic acid</subject><subject>Valproic Acid - pharmacology</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVGL1DAUhYO4rOPqP1DIg4jCVJOmTdsXQQbdFRZ82fdwm9zsRNqkm7SL45_Yv2zqDPMoBEK43zlJziHkDWefOOPyM2MdLwSrmw-t_Nixqu2K8hnZ8LYRRc2b5jnZnJEX5GVKvxhjVSmbS3IpWMdqWW3I024fg3eaorWo50SDpXoIHv7gBOOWTnv0hzk4v6U470NafrvRGdxS8IY-wjDFkMWgnaHB0wEheufvqfN0cvcYfKKwrgQHNLQ_UKARJ4Q5n0A_LC652WVhttFoloivyIWFIeHr035F7r5_u9vdFLc_r3_svt4WWrRyLgTnRmJtK1lyLvO_wJTY2lo03HAmTMes7SvAruq6stbYMwFScGmEaU1vxBV5f7TNFz8smGY1uqRxGMBjWJJqZNfItikzWB1BHUNKEa2aohshHhRnaq1BrRmrNWPVSvWvBrXK3p78l35Ecxadcs_zd6c5JA2DjeC1S2es5ZzXZZ2xL0cMcxSPDqNK2qHPUbmY21ImuP-_4y_6D6XL</recordid><startdate>19860601</startdate><enddate>19860601</enddate><creator>Poling, Alan</creator><creator>Blakely, Elbert</creator><creator>White, Wesley</creator><creator>Picker, Mitchell</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860601</creationdate><title>Chronic effects of clonazepam, phenytoin, ethosuximide, and valproic acid on learning in pigeons as assayed by a repeated acquisition procedure</title><author>Poling, Alan ; Blakely, Elbert ; White, Wesley ; Picker, Mitchell</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-311d6e5f462116000ad2e8f5371d103d90ffb4ae949925ceb03a6316d3d8dbd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Anticonvulsant drugs</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Benzodiazepinones - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Clonazepam</topic><topic>Clonazepam - pharmacology</topic><topic>Columbidae</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Tolerance</topic><topic>Ethosuximide</topic><topic>Ethosuximide - pharmacology</topic><topic>Learning - drug effects</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenytoin</topic><topic>Phenytoin - pharmacology</topic><topic>Pigeons</topic><topic>Repeated acquisition procedure</topic><topic>Tolerance</topic><topic>Valproic acid</topic><topic>Valproic Acid - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poling, Alan</creatorcontrib><creatorcontrib>Blakely, Elbert</creatorcontrib><creatorcontrib>White, Wesley</creatorcontrib><creatorcontrib>Picker, Mitchell</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poling, Alan</au><au>Blakely, Elbert</au><au>White, Wesley</au><au>Picker, Mitchell</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic effects of clonazepam, phenytoin, ethosuximide, and valproic acid on learning in pigeons as assayed by a repeated acquisition procedure</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1986-06-01</date><risdate>1986</risdate><volume>24</volume><issue>6</issue><spage>1583</spage><epage>1586</epage><pages>1583-1586</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>The acute and chronic effects of the antiepileptic drugs clonazepam (0.06, 0.13, and 0.25 mg/kg), phenytoin (2.5, 5, 7.5 mg/kg), ethosuximide (40, 80, and 120 mg/kg), and valproic acid (40, 80, and 120 mg/kg) were evaluated in pigeons responding under a repeated acquisition procedure. At certain doses, acute administrations of all drugs impaired learning (i.e., increased errors) and reduced rate of responding. Appreciable tolerance developed to these effects with chronic exposure, although the physiological mechanism responsible for this outcome is unknown.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3090564</pmid><doi>10.1016/0091-3057(86)90489-2</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 1986-06, Vol.24 (6), p.1583-1586 |
| issn | 0091-3057 1873-5177 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anticonvulsant drugs Anticonvulsants. Antiepileptics. Antiparkinson agents Benzodiazepinones - pharmacology Biological and medical sciences Clonazepam Clonazepam - pharmacology Columbidae Dose-Response Relationship, Drug Drug Tolerance Ethosuximide Ethosuximide - pharmacology Learning - drug effects Medical sciences Neuropharmacology Pharmacology. Drug treatments Phenytoin Phenytoin - pharmacology Pigeons Repeated acquisition procedure Tolerance Valproic acid Valproic Acid - pharmacology |
| title | Chronic effects of clonazepam, phenytoin, ethosuximide, and valproic acid on learning in pigeons as assayed by a repeated acquisition procedure |
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