Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy
One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmission electron mic...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1986-09, Vol.233 (4768), p.1089-1093 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1093 |
|---|---|
| container_issue | 4768 |
| container_start_page | 1089 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 233 |
| creator | Koenig, Scott Gendelman, Howard E. Orenstein, Jan M. Canto, Mauro C. Pezeshkpour, Gholam H. Yungbluth, Margaret Janotta, Frank Aksamit, Allen Martin, Malcolm A. Fauci, Anthony S. |
| description | One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmission electron microscopy, the identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals. These cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients. Infected brain macrophages may serve as a reservoir for virus and as a vehicle for viral dissemination in the infected host. |
| doi_str_mv | 10.1126/science.3016903 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_76975813</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A4374873</galeid><jstor_id>1697543</jstor_id><sourcerecordid>A4374873</sourcerecordid><originalsourceid>FETCH-LOGICAL-c730t-e4ea352ac455a778a1ab600dcd95fb657d51ee49a7b26853047b17d222a2021b3</originalsourceid><addsrcrecordid>eNqN081v0zAUAPAIgUYZnLmAFCEEh5HNH3GcHLtulEqFIm3shiLHeWldJXGxHcH-e9wl2gaq1CpSIuf9_PJiPwfBa4xOMSbJmZUKWgmnFOEkQ_RJMMIoY1FGEH0ajBCiSZQizp4HL6xdI-RjGT0KjgY-Cn5egAPplG5DXYXj2cVVeKNMZ0PVhl-FNHqzEku4G54b4e_XytoOwsropuffhfMlOBv-Vm4VXvpi_JRab4Rb3b4MnlWitvBqeB4HPz5fXk--RPPFdDYZzyPJKXIRxCAoI0LGjAnOU4FFkSBUyjJjVZEwXjIMEGeCFyRJGUUxLzAvCSGCIIILehx86PNujP7VgXV5o6yEuhYt6M7mPMk4SzHdCynDjKQp3wsJxkmCMN4LcRzHlJLEw3f_wbXuTOuXxSfzf88Z2mY76dFS1JCrttLOCLmEFoxf0xYq5V-PY8pjX6PXn3Zof5XQKLmDf_yHe-Hgj1uKztp8dvXtULm4OVSeTw-U6XT-WJ7sklLXNSwh950zWTzWZ732zWqtgSrfGNUIc5tjlG_PSD6ckXxoej_j7bATXdFAee8f4u-HuLBS1JURrVT2nqWYofiOvenZ2jptHr667TW_5X8B6VIdIQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213527501</pqid></control><display><type>article</type><title>Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>American Association for the Advancement of Science</source><creator>Koenig, Scott ; Gendelman, Howard E. ; Orenstein, Jan M. ; Canto, Mauro C. ; Pezeshkpour, Gholam H. ; Yungbluth, Margaret ; Janotta, Frank ; Aksamit, Allen ; Martin, Malcolm A. ; Fauci, Anthony S.</creator><creatorcontrib>Koenig, Scott ; Gendelman, Howard E. ; Orenstein, Jan M. ; Canto, Mauro C. ; Pezeshkpour, Gholam H. ; Yungbluth, Margaret ; Janotta, Frank ; Aksamit, Allen ; Martin, Malcolm A. ; Fauci, Anthony S.</creatorcontrib><description>One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmission electron microscopy, the identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals. These cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients. Infected brain macrophages may serve as a reservoir for virus and as a vehicle for viral dissemination in the infected host.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3016903</identifier><identifier>PMID: 3016903</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - complications ; Acquired Immunodeficiency Syndrome - microbiology ; Acquired Immunodeficiency Syndrome - pathology ; AIDS ; AIDS (Disease) ; AIDS patients ; AIDS research ; AIDS/HIV ; Biological and medical sciences ; Brain - microbiology ; Brain - pathology ; Brain Diseases - etiology ; Brain Diseases - microbiology ; Brain Diseases - pathology ; Cell lines ; Deltaretrovirus - analysis ; Deltaretrovirus - isolation & purification ; Dementia - etiology ; Dementia - microbiology ; Demyelinating Diseases - microbiology ; Demyelinating Diseases - pathology ; Encephalitis - microbiology ; Endothelial cells ; Giant cells ; HIV ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; In situ hybridization ; Macrophages ; Macrophages - microbiology ; Medical research ; Medical sciences ; Microscopy, Electron ; Neuroglia ; Neurological disorders ; Nucleic Acid Hybridization ; Papillomaviridae - isolation & purification ; Polyomaviridae ; Retroviruses ; RNA ; RNA, Viral - analysis ; Viruses</subject><ispartof>Science (American Association for the Advancement of Science), 1986-09, Vol.233 (4768), p.1089-1093</ispartof><rights>Copyright 1986 The American Association for the Advancement of Science</rights><rights>1987 INIST-CNRS</rights><rights>COPYRIGHT 1986 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1986 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Sep 5, 1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c730t-e4ea352ac455a778a1ab600dcd95fb657d51ee49a7b26853047b17d222a2021b3</citedby><cites>FETCH-LOGICAL-c730t-e4ea352ac455a778a1ab600dcd95fb657d51ee49a7b26853047b17d222a2021b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1697543$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1697543$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2882,2883,27922,27923,58015,58248</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8150403$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3016903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koenig, Scott</creatorcontrib><creatorcontrib>Gendelman, Howard E.</creatorcontrib><creatorcontrib>Orenstein, Jan M.</creatorcontrib><creatorcontrib>Canto, Mauro C.</creatorcontrib><creatorcontrib>Pezeshkpour, Gholam H.</creatorcontrib><creatorcontrib>Yungbluth, Margaret</creatorcontrib><creatorcontrib>Janotta, Frank</creatorcontrib><creatorcontrib>Aksamit, Allen</creatorcontrib><creatorcontrib>Martin, Malcolm A.</creatorcontrib><creatorcontrib>Fauci, Anthony S.</creatorcontrib><title>Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmission electron microscopy, the identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals. These cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients. Infected brain macrophages may serve as a reservoir for virus and as a vehicle for viral dissemination in the infected host.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - complications</subject><subject>Acquired Immunodeficiency Syndrome - microbiology</subject><subject>Acquired Immunodeficiency Syndrome - pathology</subject><subject>AIDS</subject><subject>AIDS (Disease)</subject><subject>AIDS patients</subject><subject>AIDS research</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Brain - microbiology</subject><subject>Brain - pathology</subject><subject>Brain Diseases - etiology</subject><subject>Brain Diseases - microbiology</subject><subject>Brain Diseases - pathology</subject><subject>Cell lines</subject><subject>Deltaretrovirus - analysis</subject><subject>Deltaretrovirus - isolation & purification</subject><subject>Dementia - etiology</subject><subject>Dementia - microbiology</subject><subject>Demyelinating Diseases - microbiology</subject><subject>Demyelinating Diseases - pathology</subject><subject>Encephalitis - microbiology</subject><subject>Endothelial cells</subject><subject>Giant cells</subject><subject>HIV</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>In situ hybridization</subject><subject>Macrophages</subject><subject>Macrophages - microbiology</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Neuroglia</subject><subject>Neurological disorders</subject><subject>Nucleic Acid Hybridization</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Polyomaviridae</subject><subject>Retroviruses</subject><subject>RNA</subject><subject>RNA, Viral - analysis</subject><subject>Viruses</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN081v0zAUAPAIgUYZnLmAFCEEh5HNH3GcHLtulEqFIm3shiLHeWldJXGxHcH-e9wl2gaq1CpSIuf9_PJiPwfBa4xOMSbJmZUKWgmnFOEkQ_RJMMIoY1FGEH0ajBCiSZQizp4HL6xdI-RjGT0KjgY-Cn5egAPplG5DXYXj2cVVeKNMZ0PVhl-FNHqzEku4G54b4e_XytoOwsropuffhfMlOBv-Vm4VXvpi_JRab4Rb3b4MnlWitvBqeB4HPz5fXk--RPPFdDYZzyPJKXIRxCAoI0LGjAnOU4FFkSBUyjJjVZEwXjIMEGeCFyRJGUUxLzAvCSGCIIILehx86PNujP7VgXV5o6yEuhYt6M7mPMk4SzHdCynDjKQp3wsJxkmCMN4LcRzHlJLEw3f_wbXuTOuXxSfzf88Z2mY76dFS1JCrttLOCLmEFoxf0xYq5V-PY8pjX6PXn3Zof5XQKLmDf_yHe-Hgj1uKztp8dvXtULm4OVSeTw-U6XT-WJ7sklLXNSwh950zWTzWZ732zWqtgSrfGNUIc5tjlG_PSD6ckXxoej_j7bATXdFAee8f4u-HuLBS1JURrVT2nqWYofiOvenZ2jptHr667TW_5X8B6VIdIQ</recordid><startdate>19860905</startdate><enddate>19860905</enddate><creator>Koenig, Scott</creator><creator>Gendelman, Howard E.</creator><creator>Orenstein, Jan M.</creator><creator>Canto, Mauro C.</creator><creator>Pezeshkpour, Gholam H.</creator><creator>Yungbluth, Margaret</creator><creator>Janotta, Frank</creator><creator>Aksamit, Allen</creator><creator>Martin, Malcolm A.</creator><creator>Fauci, Anthony S.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>19860905</creationdate><title>Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy</title><author>Koenig, Scott ; Gendelman, Howard E. ; Orenstein, Jan M. ; Canto, Mauro C. ; Pezeshkpour, Gholam H. ; Yungbluth, Margaret ; Janotta, Frank ; Aksamit, Allen ; Martin, Malcolm A. ; Fauci, Anthony S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c730t-e4ea352ac455a778a1ab600dcd95fb657d51ee49a7b26853047b17d222a2021b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - complications</topic><topic>Acquired Immunodeficiency Syndrome - microbiology</topic><topic>Acquired Immunodeficiency Syndrome - pathology</topic><topic>AIDS</topic><topic>AIDS (Disease)</topic><topic>AIDS patients</topic><topic>AIDS research</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Brain - microbiology</topic><topic>Brain - pathology</topic><topic>Brain Diseases - etiology</topic><topic>Brain Diseases - microbiology</topic><topic>Brain Diseases - pathology</topic><topic>Cell lines</topic><topic>Deltaretrovirus - analysis</topic><topic>Deltaretrovirus - isolation & purification</topic><topic>Dementia - etiology</topic><topic>Dementia - microbiology</topic><topic>Demyelinating Diseases - microbiology</topic><topic>Demyelinating Diseases - pathology</topic><topic>Encephalitis - microbiology</topic><topic>Endothelial cells</topic><topic>Giant cells</topic><topic>HIV</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>In situ hybridization</topic><topic>Macrophages</topic><topic>Macrophages - microbiology</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Neuroglia</topic><topic>Neurological disorders</topic><topic>Nucleic Acid Hybridization</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Polyomaviridae</topic><topic>Retroviruses</topic><topic>RNA</topic><topic>RNA, Viral - analysis</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koenig, Scott</creatorcontrib><creatorcontrib>Gendelman, Howard E.</creatorcontrib><creatorcontrib>Orenstein, Jan M.</creatorcontrib><creatorcontrib>Canto, Mauro C.</creatorcontrib><creatorcontrib>Pezeshkpour, Gholam H.</creatorcontrib><creatorcontrib>Yungbluth, Margaret</creatorcontrib><creatorcontrib>Janotta, Frank</creatorcontrib><creatorcontrib>Aksamit, Allen</creatorcontrib><creatorcontrib>Martin, Malcolm A.</creatorcontrib><creatorcontrib>Fauci, Anthony S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koenig, Scott</au><au>Gendelman, Howard E.</au><au>Orenstein, Jan M.</au><au>Canto, Mauro C.</au><au>Pezeshkpour, Gholam H.</au><au>Yungbluth, Margaret</au><au>Janotta, Frank</au><au>Aksamit, Allen</au><au>Martin, Malcolm A.</au><au>Fauci, Anthony S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1986-09-05</date><risdate>1986</risdate><volume>233</volume><issue>4768</issue><spage>1089</spage><epage>1093</epage><pages>1089-1093</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmission electron microscopy, the identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals. These cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients. Infected brain macrophages may serve as a reservoir for virus and as a vehicle for viral dissemination in the infected host.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3016903</pmid><doi>10.1126/science.3016903</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1986-09, Vol.233 (4768), p.1089-1093 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76975813 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - microbiology Acquired Immunodeficiency Syndrome - pathology AIDS AIDS (Disease) AIDS patients AIDS research AIDS/HIV Biological and medical sciences Brain - microbiology Brain - pathology Brain Diseases - etiology Brain Diseases - microbiology Brain Diseases - pathology Cell lines Deltaretrovirus - analysis Deltaretrovirus - isolation & purification Dementia - etiology Dementia - microbiology Demyelinating Diseases - microbiology Demyelinating Diseases - pathology Encephalitis - microbiology Endothelial cells Giant cells HIV Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology In situ hybridization Macrophages Macrophages - microbiology Medical research Medical sciences Microscopy, Electron Neuroglia Neurological disorders Nucleic Acid Hybridization Papillomaviridae - isolation & purification Polyomaviridae Retroviruses RNA RNA, Viral - analysis Viruses |
| title | Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T23%3A45%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Detection%20of%20AIDS%20Virus%20in%20Macrophages%20in%20Brain%20Tissue%20from%20AIDS%20Patients%20with%20Encephalopathy&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Koenig,%20Scott&rft.date=1986-09-05&rft.volume=233&rft.issue=4768&rft.spage=1089&rft.epage=1093&rft.pages=1089-1093&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.3016903&rft_dat=%3Cgale_proqu%3EA4374873%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213527501&rft_id=info:pmid/3016903&rft_galeid=A4374873&rft_jstor_id=1697543&rfr_iscdi=true |