Clinical profile of HIV infection
To study the clinical profile of human immunodeficiency virus (HIV) infection in children. Prospective. HIV clinic at a pediatric tertiary care center in an urban metropolis. From August 1994 onwards, 285 HIV positive children were referred to the HIV clinic. These included those intramural deliveri...
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| Veröffentlicht in: | Indian pediatrics 2001-03, Vol.38 (3), p.239-246 |
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| creator | MERCHANT, Rashid H OSWAL, Jitendra S BHAGWAT, Roshni V KARKARE, Jyotsna |
| description | To study the clinical profile of human immunodeficiency virus (HIV) infection in children.
Prospective.
HIV clinic at a pediatric tertiary care center in an urban metropolis.
From August 1994 onwards, 285 HIV positive children were referred to the HIV clinic. These included those intramural deliveries born to HIV positive mothers, those referred from other centers with a positive HIV ELISA (enzyme-linked immunosorbent assay) test and those screened routinely at our center in view of transfusion dependence and found to be HIV positive. After informed consent from either parent, the HIV status of all referred patients was retested by ELISA.
Two hundred and thirteen (74.73%) patients were below the age of five years. Vertical transmission as the route of infection was documented in 247 (86.66%), 33 (11.57%) were infected through blood and in 5 (1.75%), the mode of transmission could not be ascertained. The clinical features noted were protein energy malnutrition in 127 (44.56%), pulmonary and extrapulmonary tuberculosis in 84 (29.47%), hepatosplenomegaly in 82 (28.77%), persistent generalized lymphadenopathy in 67 (23.50%), skin lesions in 63 (22.10%), chronic diarrhea in 43 (15.08%), oral thrush in 42 (14.73%), pyrexia of unknown origin in 36 (12.63%), chronic lung disease in 32 (11.22%), chronic hypertrophic parotitis in 27 (9.47%), chronic ottorrhea in 26 (9.12%), recurrent lower respiratory tract infection in 24 (8.42%), neurological manifestations of non-tuberculous origin in 13 (4.56%) and Pneumocystis carinii pneumonia in 11(3.88%). Forty-eight (16.84%) were asymptomatic, 30 (10.52%) died of AIDS during the study period and 39 (13.68%) have been lost to follow up.
Vertical transmission was the commonest mode of infection. Perinatally infected children become symptomatic by five years of age. Protein energy malnutrition, hepatosplenomegaly and persistent generalized lymphadenopathy were common presenting features. Tuberculosis was the major co-infection. Chronic hypertrophic parotitis and chronic lung disease were distinguishing features of this study. Encephalopathy was associated with poor outcome. |
| format | Article |
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Prospective.
HIV clinic at a pediatric tertiary care center in an urban metropolis.
From August 1994 onwards, 285 HIV positive children were referred to the HIV clinic. These included those intramural deliveries born to HIV positive mothers, those referred from other centers with a positive HIV ELISA (enzyme-linked immunosorbent assay) test and those screened routinely at our center in view of transfusion dependence and found to be HIV positive. After informed consent from either parent, the HIV status of all referred patients was retested by ELISA.
Two hundred and thirteen (74.73%) patients were below the age of five years. Vertical transmission as the route of infection was documented in 247 (86.66%), 33 (11.57%) were infected through blood and in 5 (1.75%), the mode of transmission could not be ascertained. The clinical features noted were protein energy malnutrition in 127 (44.56%), pulmonary and extrapulmonary tuberculosis in 84 (29.47%), hepatosplenomegaly in 82 (28.77%), persistent generalized lymphadenopathy in 67 (23.50%), skin lesions in 63 (22.10%), chronic diarrhea in 43 (15.08%), oral thrush in 42 (14.73%), pyrexia of unknown origin in 36 (12.63%), chronic lung disease in 32 (11.22%), chronic hypertrophic parotitis in 27 (9.47%), chronic ottorrhea in 26 (9.12%), recurrent lower respiratory tract infection in 24 (8.42%), neurological manifestations of non-tuberculous origin in 13 (4.56%) and Pneumocystis carinii pneumonia in 11(3.88%). Forty-eight (16.84%) were asymptomatic, 30 (10.52%) died of AIDS during the study period and 39 (13.68%) have been lost to follow up.
Vertical transmission was the commonest mode of infection. Perinatally infected children become symptomatic by five years of age. Protein energy malnutrition, hepatosplenomegaly and persistent generalized lymphadenopathy were common presenting features. Tuberculosis was the major co-infection. Chronic hypertrophic parotitis and chronic lung disease were distinguishing features of this study. Encephalopathy was associated with poor outcome.</description><identifier>ISSN: 0019-6061</identifier><identifier>EISSN: 0974-7559</identifier><identifier>PMID: 11255299</identifier><identifier>CODEN: INPDAR</identifier><language>eng</language><publisher>New Delhi: Indian Pediatrics</publisher><subject>Adolescent ; Age Distribution ; AIDS-Related Opportunistic Infections - diagnosis ; AIDS-Related Opportunistic Infections - epidemiology ; Biological and medical sciences ; Child ; Child, Preschool ; Cohort Studies ; Disease Transmission, Infectious - statistics & numerical data ; Enzyme-Linked Immunosorbent Assay ; Female ; HIV Infections - diagnosis ; HIV Infections - epidemiology ; HIV Infections - transmission ; Human viral diseases ; Humans ; Incidence ; India - epidemiology ; Infectious Disease Transmission, Vertical - statistics & numerical data ; Infectious diseases ; Male ; Medical sciences ; Mycoses - diagnosis ; Mycoses - epidemiology ; Prospective Studies ; Risk Factors ; Serologic Tests ; Sex Distribution ; Tropical medicine ; Tuberculosis - diagnosis ; Tuberculosis - epidemiology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>Indian pediatrics, 2001-03, Vol.38 (3), p.239-246</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1084719$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11255299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MERCHANT, Rashid H</creatorcontrib><creatorcontrib>OSWAL, Jitendra S</creatorcontrib><creatorcontrib>BHAGWAT, Roshni V</creatorcontrib><creatorcontrib>KARKARE, Jyotsna</creatorcontrib><title>Clinical profile of HIV infection</title><title>Indian pediatrics</title><addtitle>Indian Pediatr</addtitle><description>To study the clinical profile of human immunodeficiency virus (HIV) infection in children.
Prospective.
HIV clinic at a pediatric tertiary care center in an urban metropolis.
From August 1994 onwards, 285 HIV positive children were referred to the HIV clinic. These included those intramural deliveries born to HIV positive mothers, those referred from other centers with a positive HIV ELISA (enzyme-linked immunosorbent assay) test and those screened routinely at our center in view of transfusion dependence and found to be HIV positive. After informed consent from either parent, the HIV status of all referred patients was retested by ELISA.
Two hundred and thirteen (74.73%) patients were below the age of five years. Vertical transmission as the route of infection was documented in 247 (86.66%), 33 (11.57%) were infected through blood and in 5 (1.75%), the mode of transmission could not be ascertained. The clinical features noted were protein energy malnutrition in 127 (44.56%), pulmonary and extrapulmonary tuberculosis in 84 (29.47%), hepatosplenomegaly in 82 (28.77%), persistent generalized lymphadenopathy in 67 (23.50%), skin lesions in 63 (22.10%), chronic diarrhea in 43 (15.08%), oral thrush in 42 (14.73%), pyrexia of unknown origin in 36 (12.63%), chronic lung disease in 32 (11.22%), chronic hypertrophic parotitis in 27 (9.47%), chronic ottorrhea in 26 (9.12%), recurrent lower respiratory tract infection in 24 (8.42%), neurological manifestations of non-tuberculous origin in 13 (4.56%) and Pneumocystis carinii pneumonia in 11(3.88%). Forty-eight (16.84%) were asymptomatic, 30 (10.52%) died of AIDS during the study period and 39 (13.68%) have been lost to follow up.
Vertical transmission was the commonest mode of infection. Perinatally infected children become symptomatic by five years of age. Protein energy malnutrition, hepatosplenomegaly and persistent generalized lymphadenopathy were common presenting features. Tuberculosis was the major co-infection. Chronic hypertrophic parotitis and chronic lung disease were distinguishing features of this study. Encephalopathy was associated with poor outcome.</description><subject>Adolescent</subject><subject>Age Distribution</subject><subject>AIDS-Related Opportunistic Infections - diagnosis</subject><subject>AIDS-Related Opportunistic Infections - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Disease Transmission, Infectious - statistics & numerical data</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - transmission</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>India - epidemiology</subject><subject>Infectious Disease Transmission, Vertical - statistics & numerical data</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mycoses - diagnosis</subject><subject>Mycoses - epidemiology</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Serologic Tests</subject><subject>Sex Distribution</subject><subject>Tropical medicine</subject><subject>Tuberculosis - diagnosis</subject><subject>Tuberculosis - epidemiology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0019-6061</issn><issn>0974-7559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj0tLxDAYRYMozlj9C1JB3BXyJc1rKUWdgQE3g9uSpAlE0odNu_DfG7Di6t7F4XLPBdpjJepKMKYuc8egKo457NBNSp8YE0oYXKMdAGGMKLVHD00MQ7A6ltM8-hBdOfrycPwow-CdXcI43KIrr2Nyd1sW6Pz6cm4O1en97dg8n6oJGCxV7bUXVHLWAXe1ZJxoZ4WgygjDrKbYdASkkEC9MB1X2BjsmcKd0lgTSQv09Dubf3ytLi1tH5J1MerBjWtqBVfZKhsU6H4DV9O7rp3m0Ov5u_1zysDjBuiUxfysBxvSP4dlLUDRH12jU2c</recordid><startdate>200103</startdate><enddate>200103</enddate><creator>MERCHANT, Rashid H</creator><creator>OSWAL, Jitendra S</creator><creator>BHAGWAT, Roshni V</creator><creator>KARKARE, Jyotsna</creator><general>Indian Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200103</creationdate><title>Clinical profile of HIV infection</title><author>MERCHANT, Rashid H ; OSWAL, Jitendra S ; BHAGWAT, Roshni V ; KARKARE, Jyotsna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p151t-4faf73865d16e48562aec7739b7b5ca30bd2187813f7bd690bb0f590d9a0a283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Age Distribution</topic><topic>AIDS-Related Opportunistic Infections - diagnosis</topic><topic>AIDS-Related Opportunistic Infections - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Disease Transmission, Infectious - statistics & numerical data</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>HIV Infections - diagnosis</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - transmission</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>India - epidemiology</topic><topic>Infectious Disease Transmission, Vertical - statistics & numerical data</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mycoses - diagnosis</topic><topic>Mycoses - epidemiology</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Serologic Tests</topic><topic>Sex Distribution</topic><topic>Tropical medicine</topic><topic>Tuberculosis - diagnosis</topic><topic>Tuberculosis - epidemiology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MERCHANT, Rashid H</creatorcontrib><creatorcontrib>OSWAL, Jitendra S</creatorcontrib><creatorcontrib>BHAGWAT, Roshni V</creatorcontrib><creatorcontrib>KARKARE, Jyotsna</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Indian pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MERCHANT, Rashid H</au><au>OSWAL, Jitendra S</au><au>BHAGWAT, Roshni V</au><au>KARKARE, Jyotsna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical profile of HIV infection</atitle><jtitle>Indian pediatrics</jtitle><addtitle>Indian Pediatr</addtitle><date>2001-03</date><risdate>2001</risdate><volume>38</volume><issue>3</issue><spage>239</spage><epage>246</epage><pages>239-246</pages><issn>0019-6061</issn><eissn>0974-7559</eissn><coden>INPDAR</coden><abstract>To study the clinical profile of human immunodeficiency virus (HIV) infection in children.
Prospective.
HIV clinic at a pediatric tertiary care center in an urban metropolis.
From August 1994 onwards, 285 HIV positive children were referred to the HIV clinic. These included those intramural deliveries born to HIV positive mothers, those referred from other centers with a positive HIV ELISA (enzyme-linked immunosorbent assay) test and those screened routinely at our center in view of transfusion dependence and found to be HIV positive. After informed consent from either parent, the HIV status of all referred patients was retested by ELISA.
Two hundred and thirteen (74.73%) patients were below the age of five years. Vertical transmission as the route of infection was documented in 247 (86.66%), 33 (11.57%) were infected through blood and in 5 (1.75%), the mode of transmission could not be ascertained. The clinical features noted were protein energy malnutrition in 127 (44.56%), pulmonary and extrapulmonary tuberculosis in 84 (29.47%), hepatosplenomegaly in 82 (28.77%), persistent generalized lymphadenopathy in 67 (23.50%), skin lesions in 63 (22.10%), chronic diarrhea in 43 (15.08%), oral thrush in 42 (14.73%), pyrexia of unknown origin in 36 (12.63%), chronic lung disease in 32 (11.22%), chronic hypertrophic parotitis in 27 (9.47%), chronic ottorrhea in 26 (9.12%), recurrent lower respiratory tract infection in 24 (8.42%), neurological manifestations of non-tuberculous origin in 13 (4.56%) and Pneumocystis carinii pneumonia in 11(3.88%). Forty-eight (16.84%) were asymptomatic, 30 (10.52%) died of AIDS during the study period and 39 (13.68%) have been lost to follow up.
Vertical transmission was the commonest mode of infection. Perinatally infected children become symptomatic by five years of age. Protein energy malnutrition, hepatosplenomegaly and persistent generalized lymphadenopathy were common presenting features. Tuberculosis was the major co-infection. Chronic hypertrophic parotitis and chronic lung disease were distinguishing features of this study. Encephalopathy was associated with poor outcome.</abstract><cop>New Delhi</cop><pub>Indian Pediatrics</pub><pmid>11255299</pmid><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Age Distribution AIDS-Related Opportunistic Infections - diagnosis AIDS-Related Opportunistic Infections - epidemiology Biological and medical sciences Child Child, Preschool Cohort Studies Disease Transmission, Infectious - statistics & numerical data Enzyme-Linked Immunosorbent Assay Female HIV Infections - diagnosis HIV Infections - epidemiology HIV Infections - transmission Human viral diseases Humans Incidence India - epidemiology Infectious Disease Transmission, Vertical - statistics & numerical data Infectious diseases Male Medical sciences Mycoses - diagnosis Mycoses - epidemiology Prospective Studies Risk Factors Serologic Tests Sex Distribution Tropical medicine Tuberculosis - diagnosis Tuberculosis - epidemiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Clinical profile of HIV infection |
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