Hematological Studies on Black Cumin Oil from the Seeds of Nigella sativa L
The methanol soluble portion of black cumin oil, which is prepared by compression of seeds of Nigella sativa L., showed inhibitory effects on arachidonic acid (AA)-induced platelet aggregation and blood coagulation. By bioactive assay of AA-induced platelet aggregation, the methanol soluble part was...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 2001, Vol.24(3), pp.307-310 |
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| container_title | Biological & pharmaceutical bulletin |
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| creator | ENOMOTO, Shigeki ASANO, Ryoya IWAHORI, Yoshihiro NARUI, Takao OKADA, Yoshihito SINGAB, Abdel Nasser B. OKUYAMA, Toru |
| description | The methanol soluble portion of black cumin oil, which is prepared by compression of seeds of Nigella sativa L., showed inhibitory effects on arachidonic acid (AA)-induced platelet aggregation and blood coagulation. By bioactive assay of AA-induced platelet aggregation, the methanol soluble part was purified to isolate a new compound 2-(2-methoxypropyl)-5-methyl-1,4-benzenediol (1) and two known compounds, thymol (2), carvacrol (3), having very strong inhibitory activity. Further, we then examined the isolated compounds (1—3) and eight related compounds by the screening test for AA-induced platelet aggregation. Compounds possessing aromatic hydroxyl and acetoxyl group had more potent activity than aspirin, which is well known as a remedy for thrombosis. |
| doi_str_mv | 10.1248/bpb.24.307 |
| format | Article |
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By bioactive assay of AA-induced platelet aggregation, the methanol soluble part was purified to isolate a new compound 2-(2-methoxypropyl)-5-methyl-1,4-benzenediol (1) and two known compounds, thymol (2), carvacrol (3), having very strong inhibitory activity. Further, we then examined the isolated compounds (1—3) and eight related compounds by the screening test for AA-induced platelet aggregation. Compounds possessing aromatic hydroxyl and acetoxyl group had more potent activity than aspirin, which is well known as a remedy for thrombosis.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.24.307</identifier><identifier>PMID: 11256491</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>2-(2-methoxypropyl)-5-methyl-1,4-benzenediol ; Animals ; Apiaceae - chemistry ; Biological and medical sciences ; black cumin oil ; Blood Coagulation - drug effects ; Blood. Blood coagulation. Reticuloendothelial system ; carvacrol ; Fibrinolysis - drug effects ; Fibrinolytic Agents - chemistry ; Fibrinolytic Agents - pharmacology ; Gas Chromatography-Mass Spectrometry ; General pharmacology ; In Vitro Techniques ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Nigella sativa ; Optical Rotation ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plants, Medicinal - chemistry ; platelet aggregation ; Platelet Aggregation - drug effects ; Rabbits ; Seeds - chemistry ; thymol</subject><ispartof>Biological and Pharmaceutical Bulletin, 2001, Vol.24(3), pp.307-310</ispartof><rights>2001 The Pharmaceutical Society of Japan</rights><rights>2001 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-679dfefd06a6546e286100e9bdbcef5acdc5f2d6f8af857bd443d472a26f19943</citedby><cites>FETCH-LOGICAL-c581t-679dfefd06a6546e286100e9bdbcef5acdc5f2d6f8af857bd443d472a26f19943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=933014$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11256491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ENOMOTO, Shigeki</creatorcontrib><creatorcontrib>ASANO, Ryoya</creatorcontrib><creatorcontrib>IWAHORI, Yoshihiro</creatorcontrib><creatorcontrib>NARUI, Takao</creatorcontrib><creatorcontrib>OKADA, Yoshihito</creatorcontrib><creatorcontrib>SINGAB, Abdel Nasser B.</creatorcontrib><creatorcontrib>OKUYAMA, Toru</creatorcontrib><title>Hematological Studies on Black Cumin Oil from the Seeds of Nigella sativa L</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The methanol soluble portion of black cumin oil, which is prepared by compression of seeds of Nigella sativa L., showed inhibitory effects on arachidonic acid (AA)-induced platelet aggregation and blood coagulation. By bioactive assay of AA-induced platelet aggregation, the methanol soluble part was purified to isolate a new compound 2-(2-methoxypropyl)-5-methyl-1,4-benzenediol (1) and two known compounds, thymol (2), carvacrol (3), having very strong inhibitory activity. Further, we then examined the isolated compounds (1—3) and eight related compounds by the screening test for AA-induced platelet aggregation. Compounds possessing aromatic hydroxyl and acetoxyl group had more potent activity than aspirin, which is well known as a remedy for thrombosis.</description><subject>2-(2-methoxypropyl)-5-methyl-1,4-benzenediol</subject><subject>Animals</subject><subject>Apiaceae - chemistry</subject><subject>Biological and medical sciences</subject><subject>black cumin oil</subject><subject>Blood Coagulation - drug effects</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>carvacrol</subject><subject>Fibrinolysis - drug effects</subject><subject>Fibrinolytic Agents - chemistry</subject><subject>Fibrinolytic Agents - pharmacology</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>General pharmacology</subject><subject>In Vitro Techniques</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nigella sativa</subject><subject>Optical Rotation</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plants, Medicinal - chemistry</subject><subject>platelet aggregation</subject><subject>Platelet Aggregation - drug effects</subject><subject>Rabbits</subject><subject>Seeds - chemistry</subject><subject>thymol</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE2LFDEQhoMo7rh68QdIQPAg9Jik83kSHdQVB_eweg7ppDKbsT_GpFvw35thhlG8VB3qod6qB6HnlKwp4_pNd-jWjK9boh6gFW25agSj4iFaEUN1I6nQV-hJKXtCiCKsfYyuKGVCckNX6MsNDG6e-mmXvOvx3byEBAVPI37fO_8Db5Yhjfg29TjmacDzPeA7gFCJiL-mHfS9w8XN6ZfD26foUXR9gWfnfo2-f_zwbXPTbG8_fd682zZeaDo3UpkQIQYinRRcAtOSEgKmC52HKJwPXkQWZNQuaqG6wHkbuGKOyUiN4e01enXae8jTzwXKbIdU_PGUEaalWCWN4lSqCr78D9xPSx7rbZby-r42ROlKvT5RPk-lZIj2kNPg8m9LiT0KtlWwZdxWwRV-cV65dAOEv-jZ6D-ZrlSjMbvRp3LhTNsSenzh7Ynal9nt4DJ2eU6-h0viqdTgy8Tfu2xhbP8Ax9WYCg</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>ENOMOTO, Shigeki</creator><creator>ASANO, Ryoya</creator><creator>IWAHORI, Yoshihiro</creator><creator>NARUI, Takao</creator><creator>OKADA, Yoshihito</creator><creator>SINGAB, Abdel Nasser B.</creator><creator>OKUYAMA, Toru</creator><general>The Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20010301</creationdate><title>Hematological Studies on Black Cumin Oil from the Seeds of Nigella sativa L</title><author>ENOMOTO, Shigeki ; ASANO, Ryoya ; IWAHORI, Yoshihiro ; NARUI, Takao ; OKADA, Yoshihito ; SINGAB, Abdel Nasser B. ; OKUYAMA, Toru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c581t-679dfefd06a6546e286100e9bdbcef5acdc5f2d6f8af857bd443d472a26f19943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>2-(2-methoxypropyl)-5-methyl-1,4-benzenediol</topic><topic>Animals</topic><topic>Apiaceae - chemistry</topic><topic>Biological and medical sciences</topic><topic>black cumin oil</topic><topic>Blood Coagulation - drug effects</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>carvacrol</topic><topic>Fibrinolysis - drug effects</topic><topic>Fibrinolytic Agents - chemistry</topic><topic>Fibrinolytic Agents - pharmacology</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>General pharmacology</topic><topic>In Vitro Techniques</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nigella sativa</topic><topic>Optical Rotation</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. 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By bioactive assay of AA-induced platelet aggregation, the methanol soluble part was purified to isolate a new compound 2-(2-methoxypropyl)-5-methyl-1,4-benzenediol (1) and two known compounds, thymol (2), carvacrol (3), having very strong inhibitory activity. Further, we then examined the isolated compounds (1—3) and eight related compounds by the screening test for AA-induced platelet aggregation. Compounds possessing aromatic hydroxyl and acetoxyl group had more potent activity than aspirin, which is well known as a remedy for thrombosis.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>11256491</pmid><doi>10.1248/bpb.24.307</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 2-(2-methoxypropyl)-5-methyl-1,4-benzenediol Animals Apiaceae - chemistry Biological and medical sciences black cumin oil Blood Coagulation - drug effects Blood. Blood coagulation. Reticuloendothelial system carvacrol Fibrinolysis - drug effects Fibrinolytic Agents - chemistry Fibrinolytic Agents - pharmacology Gas Chromatography-Mass Spectrometry General pharmacology In Vitro Techniques Magnetic Resonance Spectroscopy Male Medical sciences Nigella sativa Optical Rotation Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry platelet aggregation Platelet Aggregation - drug effects Rabbits Seeds - chemistry thymol |
| title | Hematological Studies on Black Cumin Oil from the Seeds of Nigella sativa L |
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