Prenatal cigarette smoke exposure selectively alters protein kinase C and nitric oxide synthase expression within the neonatal rat brainstem
Maternal smoking is a major risk factor for sudden infant death syndrome. Protein kinase C (PKC) and neuronal nitric oxide synthase (NOS) activities within the dorsocaudal brainstem (DB) mediate critical components of respiratory drive and could be implicated in SIDS. Thus, exposure to smoking durin...
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| Veröffentlicht in: | Neuroscience letters 2001-03, Vol.301 (2), p.135-138 |
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| creator | Hasan, Shabih U. Simakajornboon, Narong MacKinnon, Yolanda Gozal, David |
| description | Maternal smoking is a major risk factor for sudden infant death syndrome. Protein kinase C (PKC) and neuronal nitric oxide synthase (NOS) activities within the dorsocaudal brainstem (DB) mediate critical components of respiratory drive and could be implicated in SIDS. Thus, exposure to smoking during fetal life could modify the expression of these kinases in the DB. Rats were exposed to cigarette smoke or room air (Sham) from day 2 to 22 of pregnancy. Immunoblots of DB lysates at 2 days postnatally revealed no differences in PKC-α, PKC-β, and endothelial NOS expression. However, PKC-γ, PKC-δ, and neuronal NOS immunoreactivities were reduced in the cigarette smoke group. We conclude that gestational smoking is associated with selective reductions in PKC and NOS isoforms within the DB, which could decrease respiratory drive and lead to enhanced hypoxic vulnerability in infants of smoking mothers. |
| doi_str_mv | 10.1016/S0304-3940(01)01624-X |
| format | Article |
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Protein kinase C (PKC) and neuronal nitric oxide synthase (NOS) activities within the dorsocaudal brainstem (DB) mediate critical components of respiratory drive and could be implicated in SIDS. Thus, exposure to smoking during fetal life could modify the expression of these kinases in the DB. Rats were exposed to cigarette smoke or room air (Sham) from day 2 to 22 of pregnancy. Immunoblots of DB lysates at 2 days postnatally revealed no differences in PKC-α, PKC-β, and endothelial NOS expression. However, PKC-γ, PKC-δ, and neuronal NOS immunoreactivities were reduced in the cigarette smoke group. We conclude that gestational smoking is associated with selective reductions in PKC and NOS isoforms within the DB, which could decrease respiratory drive and lead to enhanced hypoxic vulnerability in infants of smoking mothers.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(01)01624-X</identifier><identifier>PMID: 11248441</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Animals, Newborn ; Biological and medical sciences ; Cigarette smoke ; Disease Models, Animal ; Female ; Fetus ; Humans ; Hypoxia ; Hypoxia, Brain - metabolism ; Infant, Newborn ; Medical sciences ; Newborn ; Nicotine ; Nitric oxide synthase ; Nitric Oxide Synthase - metabolism ; Pregnancy ; Prenatal Exposure Delayed Effects ; Protein kinase C ; Protein Kinase C - metabolism ; Rats ; Rats, Sprague-Dawley ; Respiratory Center - embryology ; Respiratory Center - enzymology ; Respiratory control ; Smoking - metabolism ; Sudden Infant Death - etiology ; sudden infant death syndrome ; Tobacco, tobacco smoking ; Toxicology</subject><ispartof>Neuroscience letters, 2001-03, Vol.301 (2), p.135-138</ispartof><rights>2001 Elsevier Science Ireland Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-90adfed3c3ccfdbda64c8f1d1e4e9bd0d5f9eee951294dd4a3ddad29db66f9b3</citedby><cites>FETCH-LOGICAL-c420t-90adfed3c3ccfdbda64c8f1d1e4e9bd0d5f9eee951294dd4a3ddad29db66f9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3940(01)01624-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=917839$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11248441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasan, Shabih U.</creatorcontrib><creatorcontrib>Simakajornboon, Narong</creatorcontrib><creatorcontrib>MacKinnon, Yolanda</creatorcontrib><creatorcontrib>Gozal, David</creatorcontrib><title>Prenatal cigarette smoke exposure selectively alters protein kinase C and nitric oxide synthase expression within the neonatal rat brainstem</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Maternal smoking is a major risk factor for sudden infant death syndrome. Protein kinase C (PKC) and neuronal nitric oxide synthase (NOS) activities within the dorsocaudal brainstem (DB) mediate critical components of respiratory drive and could be implicated in SIDS. Thus, exposure to smoking during fetal life could modify the expression of these kinases in the DB. Rats were exposed to cigarette smoke or room air (Sham) from day 2 to 22 of pregnancy. Immunoblots of DB lysates at 2 days postnatally revealed no differences in PKC-α, PKC-β, and endothelial NOS expression. However, PKC-γ, PKC-δ, and neuronal NOS immunoreactivities were reduced in the cigarette smoke group. We conclude that gestational smoking is associated with selective reductions in PKC and NOS isoforms within the DB, which could decrease respiratory drive and lead to enhanced hypoxic vulnerability in infants of smoking mothers.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Cigarette smoke</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fetus</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Hypoxia, Brain - metabolism</subject><subject>Infant, Newborn</subject><subject>Medical sciences</subject><subject>Newborn</subject><subject>Nicotine</subject><subject>Nitric oxide synthase</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Protein kinase C</subject><subject>Protein Kinase C - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Respiratory Center - embryology</subject><subject>Respiratory Center - enzymology</subject><subject>Respiratory control</subject><subject>Smoking - metabolism</subject><subject>Sudden Infant Death - etiology</subject><subject>sudden infant death syndrome</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhq0K1C6lj1BkCQnRQ8BOnGR9QmgFBakSldpDb9bEnrBuE2fr8ZbuO_DQeLurcuzJsv39M2N_jJ1K8UkK2Xy-EpVQRaWV-CjkWT4pVXFzwGZy3pZFq9vyFZs9I0fsDdGtEKKWtTpkR1KWaq6UnLG_lxEDJBi49b8hYkrIaZzukOPjaqJ1zFsc0Cb_gMOGw5AwEl_FKaEP_M4HIOQLDsHx4FP0lk-P3uXQJqTl9i6XiUjkp8D_-LTMobREHnDadY2QeBfBB0o4vmWvexgIT_brMbv-_u168aO4-HX-c_H1orCqFKnQAlyPrrKVtb3rHDTKznvpJCrUnROu7jUi6lqWWjmnoHIOXKld1zS97qpj9mFXNj_jfo2UzOjJ4jBAHmtNpm10q0RTvwjKVosM6wzWO9DGiShib1bRjxA3Rgqz1WWedJmtCyOkedJlbnLu3b7BuhvR_U_t_WTg_R4AsjD0EYL19Mxp2c6rbfsvOwrzpz14jIasx2DR-ZjVGTf5Fwb5Bw-Dtxw</recordid><startdate>20010330</startdate><enddate>20010330</enddate><creator>Hasan, Shabih U.</creator><creator>Simakajornboon, Narong</creator><creator>MacKinnon, Yolanda</creator><creator>Gozal, David</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20010330</creationdate><title>Prenatal cigarette smoke exposure selectively alters protein kinase C and nitric oxide synthase expression within the neonatal rat brainstem</title><author>Hasan, Shabih U. ; Simakajornboon, Narong ; MacKinnon, Yolanda ; Gozal, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-90adfed3c3ccfdbda64c8f1d1e4e9bd0d5f9eee951294dd4a3ddad29db66f9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Cigarette smoke</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fetus</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Hypoxia, Brain - metabolism</topic><topic>Infant, Newborn</topic><topic>Medical sciences</topic><topic>Newborn</topic><topic>Nicotine</topic><topic>Nitric oxide synthase</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Protein kinase C</topic><topic>Protein Kinase C - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Respiratory Center - embryology</topic><topic>Respiratory Center - enzymology</topic><topic>Respiratory control</topic><topic>Smoking - metabolism</topic><topic>Sudden Infant Death - etiology</topic><topic>sudden infant death syndrome</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasan, Shabih U.</creatorcontrib><creatorcontrib>Simakajornboon, Narong</creatorcontrib><creatorcontrib>MacKinnon, Yolanda</creatorcontrib><creatorcontrib>Gozal, David</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasan, Shabih U.</au><au>Simakajornboon, Narong</au><au>MacKinnon, Yolanda</au><au>Gozal, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal cigarette smoke exposure selectively alters protein kinase C and nitric oxide synthase expression within the neonatal rat brainstem</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2001-03-30</date><risdate>2001</risdate><volume>301</volume><issue>2</issue><spage>135</spage><epage>138</epage><pages>135-138</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Maternal smoking is a major risk factor for sudden infant death syndrome. Protein kinase C (PKC) and neuronal nitric oxide synthase (NOS) activities within the dorsocaudal brainstem (DB) mediate critical components of respiratory drive and could be implicated in SIDS. Thus, exposure to smoking during fetal life could modify the expression of these kinases in the DB. Rats were exposed to cigarette smoke or room air (Sham) from day 2 to 22 of pregnancy. Immunoblots of DB lysates at 2 days postnatally revealed no differences in PKC-α, PKC-β, and endothelial NOS expression. However, PKC-γ, PKC-δ, and neuronal NOS immunoreactivities were reduced in the cigarette smoke group. We conclude that gestational smoking is associated with selective reductions in PKC and NOS isoforms within the DB, which could decrease respiratory drive and lead to enhanced hypoxic vulnerability in infants of smoking mothers.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11248441</pmid><doi>10.1016/S0304-3940(01)01624-X</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Animals, Newborn Biological and medical sciences Cigarette smoke Disease Models, Animal Female Fetus Humans Hypoxia Hypoxia, Brain - metabolism Infant, Newborn Medical sciences Newborn Nicotine Nitric oxide synthase Nitric Oxide Synthase - metabolism Pregnancy Prenatal Exposure Delayed Effects Protein kinase C Protein Kinase C - metabolism Rats Rats, Sprague-Dawley Respiratory Center - embryology Respiratory Center - enzymology Respiratory control Smoking - metabolism Sudden Infant Death - etiology sudden infant death syndrome Tobacco, tobacco smoking Toxicology |
| title | Prenatal cigarette smoke exposure selectively alters protein kinase C and nitric oxide synthase expression within the neonatal rat brainstem |
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