Performance of a divergence time estimation method under a probabilistic model of rate evolution
Rates of molecular evolution vary over time and, hence, among lineages. In contrast, widely used methods for estimating divergence times from molecular sequence data assume constancy of rates. Therefore, methods for estimation of divergence times that incorporate rate variation are attractive. Impro...
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| Veröffentlicht in: | Molecular biology and evolution 2001-03, Vol.18 (3), p.352-361 |
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| container_title | Molecular biology and evolution |
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| creator | Kishino, H Thorne, J L Bruno, W J |
| description | Rates of molecular evolution vary over time and, hence, among lineages. In contrast, widely used methods for estimating divergence times from molecular sequence data assume constancy of rates. Therefore, methods for estimation of divergence times that incorporate rate variation are attractive. Improvements on a previously proposed Bayesian technique for divergence time estimation are described. New parameterization more effectively captures the phylogenetic structure of rate evolution on a tree. Fossil information and other evidence can now be included in Bayesian analyses in the form of constraints on divergence times. Simulation results demonstrate that the accuracy of divergence time estimation is substantially enhanced when constraints are included. |
| doi_str_mv | 10.1093/oxfordjournals.molbev.a003811 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Molecular biology and evolution, 2001-03, Vol.18 (3), p.352-361 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford Journals Open Access Collection; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Bayes Theorem Biological Evolution Fossils Models, Genetic Probability |
| title | Performance of a divergence time estimation method under a probabilistic model of rate evolution |
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