Melatonin reduces interleukin secretion in amyloid-β stressed mouse brain slices

Neurodegeneration in Alzheimer's disease (AD) is associated with many features of the immune system. For example, cytokines such as IL-6, synthesized by microglia and astrocytes, are associated with senile plaques. To further study the role of cytokines in early stage AD neurodegeneration, an o...

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Veröffentlicht in:	Chemico-biological interactions 2001-03, Vol.134 (1), p.101-107
Hauptverfasser:	Clapp-Lilly, Kimberly L., Smith, Mark A., Perry, George, Duffy, Lawrence K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - immunology Alzheimer Disease - metabolism Alzheimer's disease Amyloid Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - pharmacology Animals Antioxidants - pharmacology Brain - drug effects Brain - immunology Brain - metabolism Culture Media, Conditioned - metabolism Dose-Response Relationship, Drug In Vitro Techniques Interleukin-1 - metabolism Interleukin-6 - metabolism Interleukins Male Melatonin Melatonin - pharmacology Mice Mice, Inbred BALB C Organotypic culture Peptide Fragments - metabolism Peptide Fragments - pharmacology
Online-Zugang:	Volltext
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