Liposyn infusion increases plasma prostaglandin concentrations
To determine whether Liposyn infusion results in increased plasma prosta‐glandin (PG) concentrations, the following study was performed in 33 adult rabbits with chronically implanted arterial and venous catheters. Plasma PG concentrations were determined by radioimmunoassay for two vasodilators, PGE...
Gespeichert in:
| Veröffentlicht in: | Pediatric pulmonology 1986-05, Vol.2 (3), p.154-158 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 158 |
|---|---|
| container_issue | 3 |
| container_start_page | 154 |
| container_title | Pediatric pulmonology |
| container_volume | 2 |
| creator | Hunt, Carl E. Pachman, Lauren M. Hageman, Joseph R. Cobb, Michael A. Klemka, Linda |
| description | To determine whether Liposyn infusion results in increased plasma prosta‐glandin (PG) concentrations, the following study was performed in 33 adult rabbits with chronically implanted arterial and venous catheters. Plasma PG concentrations were determined by radioimmunoassay for two vasodilators, PGE2 and PGI2 (as measured by its metabolite 6‐keto‐PGF1α), and two vasoconstrictors, thromboxane (TX) A2, and PGF2α, as measured by their metabolites TXB2 and PGF2α‐M, respectively. A 1‐hour infusion of Liposyn at 4 ml per kg resulted in statistically significant increases in arterial and venous concentrations of PGE2 and 6‐keto‐PGF1α (p < 0.001) and of TXB, (p < 0.04). There were no significant changes in PGF2α‐M plasma concentrations. Liposyn infustion also resulted in a small but statistically significant increase in Pao2 of 4.7 ± 1.5 torr (p < 0.01). It is concluded that Liposyn infusion results in statistically significant increases in plasma concentrations of PGE2, 6‐keto‐PGF1α, and TXB2. |
| doi_str_mv | 10.1002/ppul.1950020307 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76972014</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76972014</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3827-b21d3c35926c387617fdb0b28d8dea5e59d1f90b5d5cf41029dbf29f7c5065123</originalsourceid><addsrcrecordid>eNqFUE1LwzAYDqLMOT17Enry1i0fTdIgCDp0Cp3u4NgxpEkq1X7ZtOj-vRkdiidP78v7fPC8DwDnCE4RhHjWNH0xRYL6HRLID8AYQSFCGAl2CMYxpzRkMSPH4MS5Nwg9JtAIjEjEUITJGFwneVO7bRXkVda7vN4turXKWRc0hXKlCpq2dp16LVRl8irQdaVt1bWq82R3Co4yVTh7tp8TsL6_e5k_hMnz4nF-k4SaxJiHKUaGaEIFZv7AGeKZSWGKYxMbq6ilwqBMwJQaqrMIQSxMmmGRcU0howiTCbgcfH2Yj966Tpa507bwoWzdO8mZ4BiiyBNnA1H71K61mWzavFTtViIod43JXWPytzGvuNhb92lpzQ9_X5HHrwb8My_s9j87uVqtkz_u4aDOXWe_ftSqfZeME07l5mkh49sl3_g35ZJ8A2zPiGc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76972014</pqid></control><display><type>article</type><title>Liposyn infusion increases plasma prostaglandin concentrations</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Hunt, Carl E. ; Pachman, Lauren M. ; Hageman, Joseph R. ; Cobb, Michael A. ; Klemka, Linda</creator><creatorcontrib>Hunt, Carl E. ; Pachman, Lauren M. ; Hageman, Joseph R. ; Cobb, Michael A. ; Klemka, Linda</creatorcontrib><description>To determine whether Liposyn infusion results in increased plasma prosta‐glandin (PG) concentrations, the following study was performed in 33 adult rabbits with chronically implanted arterial and venous catheters. Plasma PG concentrations were determined by radioimmunoassay for two vasodilators, PGE2 and PGI2 (as measured by its metabolite 6‐keto‐PGF1α), and two vasoconstrictors, thromboxane (TX) A2, and PGF2α, as measured by their metabolites TXB2 and PGF2α‐M, respectively. A 1‐hour infusion of Liposyn at 4 ml per kg resulted in statistically significant increases in arterial and venous concentrations of PGE2 and 6‐keto‐PGF1α (p < 0.001) and of TXB, (p < 0.04). There were no significant changes in PGF2α‐M plasma concentrations. Liposyn infustion also resulted in a small but statistically significant increase in Pao2 of 4.7 ± 1.5 torr (p < 0.01). It is concluded that Liposyn infusion results in statistically significant increases in plasma concentrations of PGE2, 6‐keto‐PGF1α, and TXB2.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.1950020307</identifier><identifier>PMID: 3461423</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>33 adult rabbits ; 6-keto-PGF1α ; 6-Ketoprostaglandin F1 alpha - blood ; Animals ; Dinoprost ; Dinoprostone ; Emulsions ; Fat Emulsions, Intravenous - pharmacology ; Increased plasma concentrations ; Lecithins ; Liposyn infusion ; PGE2 ; Prostaglandins - blood ; Prostaglandins E - blood ; Prostaglandins F - blood ; Rabbits ; Safflower Oil ; Soybean Oil ; Thromboxane B2 - blood ; Triglycerides - analysis ; TXB2</subject><ispartof>Pediatric pulmonology, 1986-05, Vol.2 (3), p.154-158</ispartof><rights>Copyright © 1986 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3827-b21d3c35926c387617fdb0b28d8dea5e59d1f90b5d5cf41029dbf29f7c5065123</citedby><cites>FETCH-LOGICAL-c3827-b21d3c35926c387617fdb0b28d8dea5e59d1f90b5d5cf41029dbf29f7c5065123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.1950020307$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.1950020307$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3461423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hunt, Carl E.</creatorcontrib><creatorcontrib>Pachman, Lauren M.</creatorcontrib><creatorcontrib>Hageman, Joseph R.</creatorcontrib><creatorcontrib>Cobb, Michael A.</creatorcontrib><creatorcontrib>Klemka, Linda</creatorcontrib><title>Liposyn infusion increases plasma prostaglandin concentrations</title><title>Pediatric pulmonology</title><addtitle>Pediatr. Pulmonol</addtitle><description>To determine whether Liposyn infusion results in increased plasma prosta‐glandin (PG) concentrations, the following study was performed in 33 adult rabbits with chronically implanted arterial and venous catheters. Plasma PG concentrations were determined by radioimmunoassay for two vasodilators, PGE2 and PGI2 (as measured by its metabolite 6‐keto‐PGF1α), and two vasoconstrictors, thromboxane (TX) A2, and PGF2α, as measured by their metabolites TXB2 and PGF2α‐M, respectively. A 1‐hour infusion of Liposyn at 4 ml per kg resulted in statistically significant increases in arterial and venous concentrations of PGE2 and 6‐keto‐PGF1α (p < 0.001) and of TXB, (p < 0.04). There were no significant changes in PGF2α‐M plasma concentrations. Liposyn infustion also resulted in a small but statistically significant increase in Pao2 of 4.7 ± 1.5 torr (p < 0.01). It is concluded that Liposyn infusion results in statistically significant increases in plasma concentrations of PGE2, 6‐keto‐PGF1α, and TXB2.</description><subject>33 adult rabbits</subject><subject>6-keto-PGF1α</subject><subject>6-Ketoprostaglandin F1 alpha - blood</subject><subject>Animals</subject><subject>Dinoprost</subject><subject>Dinoprostone</subject><subject>Emulsions</subject><subject>Fat Emulsions, Intravenous - pharmacology</subject><subject>Increased plasma concentrations</subject><subject>Lecithins</subject><subject>Liposyn infusion</subject><subject>PGE2</subject><subject>Prostaglandins - blood</subject><subject>Prostaglandins E - blood</subject><subject>Prostaglandins F - blood</subject><subject>Rabbits</subject><subject>Safflower Oil</subject><subject>Soybean Oil</subject><subject>Thromboxane B2 - blood</subject><subject>Triglycerides - analysis</subject><subject>TXB2</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUE1LwzAYDqLMOT17Enry1i0fTdIgCDp0Cp3u4NgxpEkq1X7ZtOj-vRkdiidP78v7fPC8DwDnCE4RhHjWNH0xRYL6HRLID8AYQSFCGAl2CMYxpzRkMSPH4MS5Nwg9JtAIjEjEUITJGFwneVO7bRXkVda7vN4turXKWRc0hXKlCpq2dp16LVRl8irQdaVt1bWq82R3Co4yVTh7tp8TsL6_e5k_hMnz4nF-k4SaxJiHKUaGaEIFZv7AGeKZSWGKYxMbq6ilwqBMwJQaqrMIQSxMmmGRcU0howiTCbgcfH2Yj966Tpa507bwoWzdO8mZ4BiiyBNnA1H71K61mWzavFTtViIod43JXWPytzGvuNhb92lpzQ9_X5HHrwb8My_s9j87uVqtkz_u4aDOXWe_ftSqfZeME07l5mkh49sl3_g35ZJ8A2zPiGc</recordid><startdate>198605</startdate><enddate>198605</enddate><creator>Hunt, Carl E.</creator><creator>Pachman, Lauren M.</creator><creator>Hageman, Joseph R.</creator><creator>Cobb, Michael A.</creator><creator>Klemka, Linda</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198605</creationdate><title>Liposyn infusion increases plasma prostaglandin concentrations</title><author>Hunt, Carl E. ; Pachman, Lauren M. ; Hageman, Joseph R. ; Cobb, Michael A. ; Klemka, Linda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3827-b21d3c35926c387617fdb0b28d8dea5e59d1f90b5d5cf41029dbf29f7c5065123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>33 adult rabbits</topic><topic>6-keto-PGF1α</topic><topic>6-Ketoprostaglandin F1 alpha - blood</topic><topic>Animals</topic><topic>Dinoprost</topic><topic>Dinoprostone</topic><topic>Emulsions</topic><topic>Fat Emulsions, Intravenous - pharmacology</topic><topic>Increased plasma concentrations</topic><topic>Lecithins</topic><topic>Liposyn infusion</topic><topic>PGE2</topic><topic>Prostaglandins - blood</topic><topic>Prostaglandins E - blood</topic><topic>Prostaglandins F - blood</topic><topic>Rabbits</topic><topic>Safflower Oil</topic><topic>Soybean Oil</topic><topic>Thromboxane B2 - blood</topic><topic>Triglycerides - analysis</topic><topic>TXB2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hunt, Carl E.</creatorcontrib><creatorcontrib>Pachman, Lauren M.</creatorcontrib><creatorcontrib>Hageman, Joseph R.</creatorcontrib><creatorcontrib>Cobb, Michael A.</creatorcontrib><creatorcontrib>Klemka, Linda</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hunt, Carl E.</au><au>Pachman, Lauren M.</au><au>Hageman, Joseph R.</au><au>Cobb, Michael A.</au><au>Klemka, Linda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liposyn infusion increases plasma prostaglandin concentrations</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr. Pulmonol</addtitle><date>1986-05</date><risdate>1986</risdate><volume>2</volume><issue>3</issue><spage>154</spage><epage>158</epage><pages>154-158</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><abstract>To determine whether Liposyn infusion results in increased plasma prosta‐glandin (PG) concentrations, the following study was performed in 33 adult rabbits with chronically implanted arterial and venous catheters. Plasma PG concentrations were determined by radioimmunoassay for two vasodilators, PGE2 and PGI2 (as measured by its metabolite 6‐keto‐PGF1α), and two vasoconstrictors, thromboxane (TX) A2, and PGF2α, as measured by their metabolites TXB2 and PGF2α‐M, respectively. A 1‐hour infusion of Liposyn at 4 ml per kg resulted in statistically significant increases in arterial and venous concentrations of PGE2 and 6‐keto‐PGF1α (p < 0.001) and of TXB, (p < 0.04). There were no significant changes in PGF2α‐M plasma concentrations. Liposyn infustion also resulted in a small but statistically significant increase in Pao2 of 4.7 ± 1.5 torr (p < 0.01). It is concluded that Liposyn infusion results in statistically significant increases in plasma concentrations of PGE2, 6‐keto‐PGF1α, and TXB2.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>3461423</pmid><doi>10.1002/ppul.1950020307</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8755-6863 |
| ispartof | Pediatric pulmonology, 1986-05, Vol.2 (3), p.154-158 |
| issn | 8755-6863 1099-0496 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76972014 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 33 adult rabbits 6-keto-PGF1α 6-Ketoprostaglandin F1 alpha - blood Animals Dinoprost Dinoprostone Emulsions Fat Emulsions, Intravenous - pharmacology Increased plasma concentrations Lecithins Liposyn infusion PGE2 Prostaglandins - blood Prostaglandins E - blood Prostaglandins F - blood Rabbits Safflower Oil Soybean Oil Thromboxane B2 - blood Triglycerides - analysis TXB2 |
| title | Liposyn infusion increases plasma prostaglandin concentrations |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T15%3A19%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Liposyn%20infusion%20increases%20plasma%20prostaglandin%20concentrations&rft.jtitle=Pediatric%20pulmonology&rft.au=Hunt,%20Carl%20E.&rft.date=1986-05&rft.volume=2&rft.issue=3&rft.spage=154&rft.epage=158&rft.pages=154-158&rft.issn=8755-6863&rft.eissn=1099-0496&rft_id=info:doi/10.1002/ppul.1950020307&rft_dat=%3Cproquest_cross%3E76972014%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76972014&rft_id=info:pmid/3461423&rfr_iscdi=true |