Application of LC-MS analysis to the characterisation of the in vitro and in vivo metabolite profiles of RGH-1756 in the rat

RGH-1756, 1-(2-methoxy-phenyl)-4-{4-[4-(6-imidazol[2,1-b] thiazolyl)-phenoxy]-butyl-4- 14C}-piperazine dimethane is a novel atypical antipsychotic drug candidate of Gedeon Richter Ltd. The metabolic pathways of the compound have been investigated by profiling the metabolites present in plasma, bile,...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2001-03, Vol.24 (5), p.877-885
Hauptverfasser:	GEMESI, L. I, KAPAS, M, SZEBERENYI, Sz
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(2-methoxy-phenyl)-4-{4-[4-(6-imidazol [2,1-b]thiazolyl)-phenoxy]-butyl-4- 14C}-piperazine Analysis Animals Antipsychotic Bile - metabolism Biological and medical sciences Chromatography, High Pressure Liquid - methods Dopamine Antagonists - blood Dopamine Antagonists - metabolism Dopamine Antagonists - pharmacokinetics Dopamine D2 Receptor Antagonists Feces - chemistry General pharmacology In vitro and in vivo metabolism In Vitro Techniques LC-MS Male Mass Spectrometry - methods Medical sciences Pharmacology. Drug treatments Piperazines - metabolism Piperazines - pharmacokinetics Radiometry Rat Rats Rats, Wistar Receptors, Dopamine D3 RGH-1756 Thiazoles - metabolism Thiazoles - pharmacokinetics Turboionspray
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