No-Flow Ischemia Inhibits Insulin Signaling in Heart by Decreasing Intracellular pH

Glucose-insulin-potassium solutions exert beneficial effects on the ischemic heart by reducing infarct size and mortality and improving postischemic left ventricular function. Insulin could be the critical protective component of this mixture, although the insulin response of the ischemic and postis...

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Veröffentlicht in:	Circulation research 2001-03, Vol.88 (5), p.513-519
Hauptverfasser:	Beauloye, Christophe, Bertrand, Luc, Krause, Ulrike, Marsin, Anne-Sophie, Dresselaers, Tom, Vanstapel, Florent, Vanoverschelde, Jean-Louis, Hue, Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium-Calmodulin-Dependent Protein Kinases - drug effects Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cardiology. Vascular system Coronary heart disease Dose-Response Relationship, Drug Enzyme Activation - drug effects Glycogen Synthase Kinase 3 Glycogen Synthase Kinases Heart Heart - drug effects Heart - physiology Hydrogen-Ion Concentration Insulin - pharmacology Insulin Receptor Substrate Proteins Male Medical sciences Myocardial Ischemia - physiopathology Myocardial Reperfusion Myocardium - cytology Myocardium - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphoproteins - metabolism Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Rats Rats, Wistar Receptor, Insulin - metabolism Ribosomal Protein S6 Kinases - drug effects Ribosomal Protein S6 Kinases - metabolism Signal Transduction
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