The influence of NO-containing ruthenium complexes on mouse hippocampal evoked potentials in vitro
The influence of different, nitric oxide-containing ruthenium complexes on the evoked potentials recorded from the CA1 region of the mouse hippocampus in vitro has been investigated. Of the compounds tested, only trans-[(NO)(P(OEt) 3)(NH 3) 4Ru](PF 6) 3 (1–2.5 mM) exerted a strong facilitatory actio...
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| Veröffentlicht in: | Life sciences (1973) 2001-02, Vol.68 (13), p.1535-1544 |
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| container_title | Life sciences (1973) |
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| creator | Wieraszko, Andrzej Clarke, Michael J. Lang, Douglas R. Lopes, Luiz G.F. Franco, Douglas W. |
| description | The influence of different, nitric oxide-containing ruthenium complexes on the evoked potentials recorded from the CA1 region of the mouse hippocampus
in vitro has been investigated. Of the compounds tested, only
trans-[(NO)(P(OEt)
3)(NH
3)
4Ru](PF
6)
3 (1–2.5 mM) exerted a strong facilitatory action on the population spike, the EPSP, and the spontaneous activity. Its activity probably depends upon its ability to release NO following reduction. The phosphito ligand is important both in terms of adjusting the reduction potential of the complex to be biologically accessible and in labilizing the coordinated NO. The effects of this compound could not be reversed by perfusion. Scavenging NO in slices preincubated with oxyhemoglobin prior to the addition of this compound eliminated its neurophysiological effects. The control molecules
trans-[(P(OEt)
3)
2(NH
3)
4Ru](PF
6)
2,
trans-[(H
2O)(P(OEt)
3) (NH
3)
4Ru](PF
6)
3, and [(NO)(NH
3)
5Ru]Cl
3, which are structurally similar, but unable to generate NO, were ineffective. NaNO
2 suppressed neuronal firing. Attempts to induce Long-Term Potentiation (LTP) at the time of maximal effect of
trans-[(NO)(P(OEt)
3)(NH
3)
4Ru](PF
6)
3 were unsuccessful, suggesting that the mechanism of amplification induced by
trans-[(NO)(P(OEt)
3)(NH
3)
4Ru](PF
6)
3 and LTP may share common pathways. |
| doi_str_mv | 10.1016/S0024-3205(01)00951-1 |
| format | Article |
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in vitro has been investigated. Of the compounds tested, only
trans-[(NO)(P(OEt)
3)(NH
3)
4Ru](PF
6)
3 (1–2.5 mM) exerted a strong facilitatory action on the population spike, the EPSP, and the spontaneous activity. Its activity probably depends upon its ability to release NO following reduction. The phosphito ligand is important both in terms of adjusting the reduction potential of the complex to be biologically accessible and in labilizing the coordinated NO. The effects of this compound could not be reversed by perfusion. Scavenging NO in slices preincubated with oxyhemoglobin prior to the addition of this compound eliminated its neurophysiological effects. The control molecules
trans-[(P(OEt)
3)
2(NH
3)
4Ru](PF
6)
2,
trans-[(H
2O)(P(OEt)
3) (NH
3)
4Ru](PF
6)
3, and [(NO)(NH
3)
5Ru]Cl
3, which are structurally similar, but unable to generate NO, were ineffective. NaNO
2 suppressed neuronal firing. Attempts to induce Long-Term Potentiation (LTP) at the time of maximal effect of
trans-[(NO)(P(OEt)
3)(NH
3)
4Ru](PF
6)
3 were unsuccessful, suggesting that the mechanism of amplification induced by
trans-[(NO)(P(OEt)
3)(NH
3)
4Ru](PF
6)
3 and LTP may share common pathways.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(01)00951-1</identifier><identifier>PMID: 11253170</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Excitatory Postsynaptic Potentials - drug effects ; Excitatory Postsynaptic Potentials - physiology ; Female ; Hippocampus - drug effects ; Hippocampus - physiology ; In Vitro Techniques ; Long term potentiation ; Male ; Mice ; Mice, Inbred C57BL ; Nitric oxide ; Nitric Oxide - chemistry ; Nitric Oxide - metabolism ; Ruthenium ; Ruthenium Compounds - chemistry ; Ruthenium Compounds - pharmacology ; Sodium Nitrite - pharmacology</subject><ispartof>Life sciences (1973), 2001-02, Vol.68 (13), p.1535-1544</ispartof><rights>2001 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-a6a4c16c0725109a04b0eadbd206e99b4b492b051c159f973ba7f1926ca62c613</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0024-3205(01)00951-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11253170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wieraszko, Andrzej</creatorcontrib><creatorcontrib>Clarke, Michael J.</creatorcontrib><creatorcontrib>Lang, Douglas R.</creatorcontrib><creatorcontrib>Lopes, Luiz G.F.</creatorcontrib><creatorcontrib>Franco, Douglas W.</creatorcontrib><title>The influence of NO-containing ruthenium complexes on mouse hippocampal evoked potentials in vitro</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>The influence of different, nitric oxide-containing ruthenium complexes on the evoked potentials recorded from the CA1 region of the mouse hippocampus
in vitro has been investigated. Of the compounds tested, only
trans-[(NO)(P(OEt)
3)(NH
3)
4Ru](PF
6)
3 (1–2.5 mM) exerted a strong facilitatory action on the population spike, the EPSP, and the spontaneous activity. Its activity probably depends upon its ability to release NO following reduction. The phosphito ligand is important both in terms of adjusting the reduction potential of the complex to be biologically accessible and in labilizing the coordinated NO. The effects of this compound could not be reversed by perfusion. Scavenging NO in slices preincubated with oxyhemoglobin prior to the addition of this compound eliminated its neurophysiological effects. The control molecules
trans-[(P(OEt)
3)
2(NH
3)
4Ru](PF
6)
2,
trans-[(H
2O)(P(OEt)
3) (NH
3)
4Ru](PF
6)
3, and [(NO)(NH
3)
5Ru]Cl
3, which are structurally similar, but unable to generate NO, were ineffective. NaNO
2 suppressed neuronal firing. Attempts to induce Long-Term Potentiation (LTP) at the time of maximal effect of
trans-[(NO)(P(OEt)
3)(NH
3)
4Ru](PF
6)
3 were unsuccessful, suggesting that the mechanism of amplification induced by
trans-[(NO)(P(OEt)
3)(NH
3)
4Ru](PF
6)
3 and LTP may share common pathways.</description><subject>Animals</subject><subject>Excitatory Postsynaptic Potentials - drug effects</subject><subject>Excitatory Postsynaptic Potentials - physiology</subject><subject>Female</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>In Vitro Techniques</subject><subject>Long term potentiation</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - chemistry</subject><subject>Nitric Oxide - metabolism</subject><subject>Ruthenium</subject><subject>Ruthenium Compounds - chemistry</subject><subject>Ruthenium Compounds - pharmacology</subject><subject>Sodium Nitrite - pharmacology</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq2KqiwfP6HIJ0QPoTNJ7NQnhBCllVD30OVsOc6ka5rYwU5W7b8ny67gyGk00jPzzjyMfUa4RED59TdAXmZFDuIC8AuAEpjhB7bAb5XKQBZ4wBavyCE7SukRAISoik_sEDEXBVawYPVqTdz5tpvIW-Kh5b-WmQ1-NM47_4fHaVyTd1PPbeiHjv5R4sHzPkyJ-NoNQ7CmH0zHaRP-UsOHMJIfnenSvJVv3BjDCfvYzj2d7usxe_h-u7r5kd0v737eXN9ntpA4Zkaa0qK0UOUCQRkoayDT1E0OkpSqy7pUeQ0CLQrVqqqoTdWiyqU1MrcSi2N2vts7xPA0URp175KlrjOe5nN1JZWc5YgZFDvQxpBSpFYP0fUm_tcIeitXv8jVW3MaUL_I1duAs33AVPfUvE3tbc7A1Q6g-c2No6iTdVuvjYtkR90E907EM-tcigM</recordid><startdate>20010216</startdate><enddate>20010216</enddate><creator>Wieraszko, Andrzej</creator><creator>Clarke, Michael J.</creator><creator>Lang, Douglas R.</creator><creator>Lopes, Luiz G.F.</creator><creator>Franco, Douglas W.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010216</creationdate><title>The influence of NO-containing ruthenium complexes on mouse hippocampal evoked potentials in vitro</title><author>Wieraszko, Andrzej ; Clarke, Michael J. ; Lang, Douglas R. ; Lopes, Luiz G.F. ; Franco, Douglas W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-a6a4c16c0725109a04b0eadbd206e99b4b492b051c159f973ba7f1926ca62c613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Excitatory Postsynaptic Potentials - drug effects</topic><topic>Excitatory Postsynaptic Potentials - physiology</topic><topic>Female</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>In Vitro Techniques</topic><topic>Long term potentiation</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - chemistry</topic><topic>Nitric Oxide - metabolism</topic><topic>Ruthenium</topic><topic>Ruthenium Compounds - chemistry</topic><topic>Ruthenium Compounds - pharmacology</topic><topic>Sodium Nitrite - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wieraszko, Andrzej</creatorcontrib><creatorcontrib>Clarke, Michael J.</creatorcontrib><creatorcontrib>Lang, Douglas R.</creatorcontrib><creatorcontrib>Lopes, Luiz G.F.</creatorcontrib><creatorcontrib>Franco, Douglas W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wieraszko, Andrzej</au><au>Clarke, Michael J.</au><au>Lang, Douglas R.</au><au>Lopes, Luiz G.F.</au><au>Franco, Douglas W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of NO-containing ruthenium complexes on mouse hippocampal evoked potentials in vitro</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2001-02-16</date><risdate>2001</risdate><volume>68</volume><issue>13</issue><spage>1535</spage><epage>1544</epage><pages>1535-1544</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>The influence of different, nitric oxide-containing ruthenium complexes on the evoked potentials recorded from the CA1 region of the mouse hippocampus
in vitro has been investigated. Of the compounds tested, only
trans-[(NO)(P(OEt)
3)(NH
3)
4Ru](PF
6)
3 (1–2.5 mM) exerted a strong facilitatory action on the population spike, the EPSP, and the spontaneous activity. Its activity probably depends upon its ability to release NO following reduction. The phosphito ligand is important both in terms of adjusting the reduction potential of the complex to be biologically accessible and in labilizing the coordinated NO. The effects of this compound could not be reversed by perfusion. Scavenging NO in slices preincubated with oxyhemoglobin prior to the addition of this compound eliminated its neurophysiological effects. The control molecules
trans-[(P(OEt)
3)
2(NH
3)
4Ru](PF
6)
2,
trans-[(H
2O)(P(OEt)
3) (NH
3)
4Ru](PF
6)
3, and [(NO)(NH
3)
5Ru]Cl
3, which are structurally similar, but unable to generate NO, were ineffective. NaNO
2 suppressed neuronal firing. Attempts to induce Long-Term Potentiation (LTP) at the time of maximal effect of
trans-[(NO)(P(OEt)
3)(NH
3)
4Ru](PF
6)
3 were unsuccessful, suggesting that the mechanism of amplification induced by
trans-[(NO)(P(OEt)
3)(NH
3)
4Ru](PF
6)
3 and LTP may share common pathways.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>11253170</pmid><doi>10.1016/S0024-3205(01)00951-1</doi><tpages>10</tpages></addata></record> |
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| ispartof | Life sciences (1973), 2001-02, Vol.68 (13), p.1535-1544 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Female Hippocampus - drug effects Hippocampus - physiology In Vitro Techniques Long term potentiation Male Mice Mice, Inbred C57BL Nitric oxide Nitric Oxide - chemistry Nitric Oxide - metabolism Ruthenium Ruthenium Compounds - chemistry Ruthenium Compounds - pharmacology Sodium Nitrite - pharmacology |
| title | The influence of NO-containing ruthenium complexes on mouse hippocampal evoked potentials in vitro |
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