The Granzyme B Inhibitor, Protease Inhibitor 9, Is Mainly Expressed by Dendritic Cells and at Immune-Privileged Sites

Granzyme B is released from CTLs and NK cells and an important mediator of CTL/NK-induced apoptosis in target cells. The human intracellular serpin proteinase inhibitor (PI)9 is the only human protein able to inhibit the activity of granzyme B. As a first step to elucidate the physiological role of...

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Veröffentlicht in:	The Journal of immunology (1950) 2001-03, Vol.166 (5), p.3218-3225
Hauptverfasser:	Bladergroen, Bellinda A, Strik, Merel C. M, Bovenschen, Niels, van Berkum, Oskar, Scheffer, George L, Meijer, Chris J. L. M, Hack, C. Erik, Kummer, J. Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Antibody Specificity Blotting, Western COS Cells Dendritic Cells - immunology Dendritic Cells - metabolism Endothelium, Vascular - enzymology Endothelium, Vascular - immunology Eye - enzymology Eye - immunology Female granzyme B Granzymes Humans immune privilege Lymphoid Tissue - enzymology Lymphoid Tissue - immunology Male Mice Mice, Inbred BALB C Organ Specificity - immunology Ovary - enzymology Ovary - immunology Placenta - enzymology Placenta - immunology proteinase inhibitor 9 Serine Endopeptidases - metabolism Serine Proteinase Inhibitors - biosynthesis Serine Proteinase Inhibitors - immunology Serine Proteinase Inhibitors - physiology Serpins - biosynthesis Serpins - immunology Serpins - physiology Testis - enzymology Testis - immunology Transfection
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