Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids

Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids

Several polyhydroxyalkaloids, including the eight presently known to occur in plants, have been compared as inhibitors of mouse gut digestive disaccharidases. The indolizidine castanospermine inhibited all activities tested, but others showed a selectivity which could be of value in studies of carbo...

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Veröffentlicht in:Life sciences (1973) 1986-08, Vol.39 (7), p.645-650
Hauptverfasser: Scofield, A.M., Fellows, L.E., Nash, R.J., Fleet, G.W.J.
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids - pharmacology
Animals
Biological and medical sciences
Chemical Phenomena
Chemistry
Disaccharidases - antagonists & inhibitors
Female
General and cellular metabolism. Vitamins
Imino Furanoses
In Vitro Techniques
Indolizines
Intestinal Mucosa - enzymology
Intestines - enzymology
Mannitol - analogs & derivatives
Medical sciences
Mice
Pharmacology. Drug treatments
Pyrrolidines
Swainsonine
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Beschreibung
Zusammenfassung:Several polyhydroxyalkaloids, including the eight presently known to occur in plants, have been compared as inhibitors of mouse gut digestive disaccharidases. The indolizidine castanospermine inhibited all activities tested, but others showed a selectivity which could be of value in studies of carbohydrate digestion and errors of metabolism.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(86)90046-9