A comparison of oral and parenteral routes for therapeutic vaccination with HSV-2 ISCOMs in mice; cytokine profiles, antibody responses and protection

It is likely that recurrent infections with HSV-2 (or HSV-1) are influenced by local levels of immunity at mucosal surfaces, when virus reactivated from the latent state is infecting mucosal epithelial cells. Increasing the levels of cellular and humoral immunity through immunisation and maintaining...

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Veröffentlicht in:	Antiviral research 2001-02, Vol.49 (2), p.83-99
Hauptverfasser:	Mohamedi, S.A, Heath, A.W, Jennings, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - blood Antibody responses Antigens, Viral - immunology Biological and medical sciences Cytokine responses Cytokines - biosynthesis Female Herpes Genitalis - prevention & control Herpes Simplex - prevention & control Herpes simplex virus 1 Herpes simplex virus 2 Herpesvirus 1, Human - immunology Herpesvirus 2, Human - immunology Herpesvirus Vaccines - administration & dosage Herpesvirus Vaccines - immunology HSV-2 Immunomodulators ISCOMs - administration & dosage ISCOMs - immunology Lymphocyte Activation Medical sciences Mice Mice, Inbred BALB C Pharmacology. Drug treatments Therapeutic immunisation Vaccination
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