Non-peptidic inhibitors of human chymase. synthesis, structure-activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones

Chymase possesses a wide variety of actions, including promotion of angiotensin II production and histamine release from mast cells. However, due to a lack of effective inhibitors featuring both high inhibitory activity and high metabolic stability, the pathophysiological role of chymase has not bee...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2001-02, Vol.9 (2), p.301-315
Hauptverfasser: AKAHOSHI, Fumihiko, ASHIMORI, Atsuyuki, NAKAMURA, Norifumi, YOSHIMURA, Takuya, IMADA, Teruaki, NAKAJIMA, Masahide, MITSUTOMI, Naoko, KUWAHARA, Shigeki, OHTSUKA, Tatsuyuki, FUKAYA, Chikara, MIYAZAKI, Mizuo
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Sprache:eng
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