Pseudocapillarization and associated energy limitation in the aged rat liver

Age-related impairment of drug metabolism by the liver is consistent with hepatocyte hypoxia, suggestive of the development of a diffusional barrier to oxygen supply. Because the effects of aging on the diffusional pathway (sinusoidal endothelium and space of Disse) have not been described, we perfo...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2001-03, Vol.33 (3), p.537-543
Hauptverfasser:	Le Couteur, David G., Cogger, Victoria C., Markus, Astrid M.A., Harvey, Peta J., Yin, Zhan-Li, Ansselin, Annick D., McLean, Allan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Aging - physiology Animals Biological and medical sciences Capillaries Collagen - metabolism Diffusion Digestive system Energy Metabolism Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Liver Circulation Magnetic Resonance Spectroscopy Male Medical sciences Microscopy, Electron Microscopy, Electron, Scanning Oxygen Consumption Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phosphates - metabolism Rats Rats, Inbred F344 von Willebrand Factor - metabolism
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