The hypothalamic-pituitary-adrenal axis of patients with severe sepsis: Altered response to corticotropin-releasing hormone

OBJECTIVETo investigate the functional integrity of the hypothalamic-pituitary-adrenal (HPA) axis in patients with severe sepsis by stimulating with corticotropin-releasing hormone (CRH). DESIGNProspective observational study in consecutive intensive care unit patients with severe sepsis. SETTINGSur...

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Veröffentlicht in:	Critical care medicine 2001-02, Vol.29 (2), p.310-316
Hauptverfasser:	Schroeder, Stefan, Wichers, Maria, Klingmüller, Dietrich, Höfer, Martina, Lehmann, Lutz Eric, von Spiegel, Tilman, Hering, Rudolf, Putensen, Christian, Hoeft, Andreas, Stüber, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenal Insufficiency - blood Adrenocorticotropic Hormone - blood Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Bacterial Infections - diagnosis Bacterial Infections - metabolism Bacterial Infections - mortality Bacterial Infections - physiopathology Biological and medical sciences Case-Control Studies Corticotropin-Releasing Hormone - physiology Critical Care Emergency and intensive care: infection, septic shock Female Humans Hydrocortisone - blood Hypopituitarism - blood Hypothalamo-Hypophyseal System - physiopathology Intensive care medicine Male Medical sciences Middle Aged Pituitary-Adrenal System - physiopathology Prospective Studies Sepsis - diagnosis Sepsis - metabolism Sepsis - mortality Sepsis - physiopathology Severity of Illness Index Survival Analysis
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