Bioactive immobilization of r-hirudin on CVD-coated metallic implant devices

The poor biocompatibility of metallic coronary stents which leads to un-satisfying restenosis rates is mainly caused by contact activation of blood cells, smooth muscle cells and endothelial cells. Mimicking a metal surface with a biocompatible coating that actively suppresses mechanisms leading to...

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Veröffentlicht in:	Biomaterials 2001-04, Vol.22 (8), p.817-826
Hauptverfasser:	Lahann, Joerg, Klee, Doris, Pluester, Wilhelm, Hoecker, Hartwig
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biological and medical sciences Biomimetics Chemical vapor deposition Coronary Disease - therapy Hirudin Hirudins - administration & dosage Hirudins - metabolism Humans Immobilization In Vitro Techniques Materials Testing Medical sciences Metals Microscopy, Atomic Force Microscopy, Electron, Scanning Platelet Adhesiveness Polymers - chemical synthesis Polymers - chemistry Prostheses and Implants Restenosis Stent Stents Surface Properties Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Thrombin - metabolism Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels Volatilization
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