Structure-activity relationships among α-(N)-heterocyclic acyl thiosemicarbazones and related compounds as inhibitors of herpes simplex virus type 1-specified ribonucleoside diphosphate reductase

2-Acetylpyridine thiosemicarbazone, a potent antiviral drug, and 13 analogues were examined as inhibitors of partially purified herpes simplex virus type 1-specified ribonucleoside diphosphate reductase. N4,N4-Azacycloheptane derivatives were more active than their N4-unsubstituted analogues. Seleno...

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Veröffentlicht in:	Journal of general virology 1986-08, Vol.67 (8), p.1625-1632
Hauptverfasser:	TURK, S. R, SHIPMAN, C. JR, DRACH, J. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Action of physical and chemical agents Biological and medical sciences Fundamental and applied biological sciences. Psychology herpes simplex virus 1 Microbiology Ribonucleoside Diphosphate Reductase - antagonists & inhibitors Ribonucleotide Reductases - antagonists & inhibitors Semicarbazides - pharmacology Semicarbazones - pharmacology Simplexvirus - drug effects Simplexvirus - enzymology Structure-Activity Relationship Thiosemicarbazones - pharmacology Virology
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