Vitamin D supplementation during pregnancy: Effect on neonatal calcium homeostasis
We assessed whether modification of vitamin D nutritional status during the last trimester of pregnancy affects maternal and neonatal calcium homeostasis. At the end of the first trimester, 40 pregnant women were randomly assigned to either of two groups, and blood taken to assess the basal values o...
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| Veröffentlicht in: | The Journal of pediatrics 1986-08, Vol.109 (2), p.328-334 |
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| container_title | The Journal of pediatrics |
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| creator | Delvin, E.E. Salle, B.L. Glorieux, F.H. Adeleine, P. David, L.S. |
| description | We assessed whether modification of vitamin D nutritional status during the last trimester of pregnancy affects maternal and neonatal calcium homeostasis. At the end of the first trimester, 40 pregnant women were randomly assigned to either of two groups, and blood taken to assess the basal values of Ca, Pi, Mg, iPTH, 25-OHD, and 1,25(OH)
2D. From the sixth month on, group 1 (+D) received 1000 IU vitamin D
3 daily; group 2 (−D) served as control. At the time of delivery, maternal serum 25-OHD was higher in the +D group (P |
| doi_str_mv | 10.1016/S0022-3476(86)80396-1 |
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2D. From the sixth month on, group 1 (+D) received 1000 IU vitamin D
3 daily; group 2 (−D) served as control. At the time of delivery, maternal serum 25-OHD was higher in the +D group (P<0.0005). Ca, Pi, iPTH, and 1,25(OH)
2D were not affected. At term, venous cord 25-OHD levels were also higher in the +D group (P<0.0005), and 1,25(OH)
2D levels slightly lower (P<0.05), but neither Ca, Pi, nor iPTH differed between the two groups. Serum Ca
T
dropped significantly (P<0.002) at 4 days of age in the infants from both groups, although to a lesser extent in these from the +D group (P<0.05). Circulating iPTH increased in both groups. Serum 25-OHD remained low in the −D group, and dropped slightly in the +D group; 1,25(OH)
2D remained stable during the first 4 days of life in the −D group, and increased in the +D group (P<0.001). Our data demonstrate the importance of providing adequate maternal vitamin D stores to ensure better perinatal handling of calcium. This is of particular importance for populations at risk for hypovitaminosis D.]]></description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(86)80396-1</identifier><identifier>PMID: 3488384</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>25-Hydroxyvitamin D 2 ; ASREGIME ALIMENTAIRE ; Biological and medical sciences ; CALCIO ; CALCIUM ; Calcium - blood ; Ergocalciferols - analogs & derivatives ; Ergocalciferols - blood ; Female ; Fetal Blood - analysis ; Genital system. Reproduction ; GESTACION ; GESTATION ; Homeostasis ; Humans ; INFA ; Infant, Newborn ; Magnesium - blood ; Medical sciences ; NOUVEA ; Parathyroid Hormone - blood ; Pharmacology. Drug treatments ; Phosphates - blood ; Pregnancy ; r)DIETA ; Random Allocation ; Vitamin D - therapeutic use ; VITAMINA D ; VITAMINE D</subject><ispartof>The Journal of pediatrics, 1986-08, Vol.109 (2), p.328-334</ispartof><rights>1986 The C. V. Mosby Company</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-43b61966fec7606210cf4d90f70666882f1956c507767a13b2ce75406f172bbc3</citedby><cites>FETCH-LOGICAL-c439t-43b61966fec7606210cf4d90f70666882f1956c507767a13b2ce75406f172bbc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(86)80396-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8081709$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3488384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delvin, E.E.</creatorcontrib><creatorcontrib>Salle, B.L.</creatorcontrib><creatorcontrib>Glorieux, F.H.</creatorcontrib><creatorcontrib>Adeleine, P.</creatorcontrib><creatorcontrib>David, L.S.</creatorcontrib><title>Vitamin D supplementation during pregnancy: Effect on neonatal calcium homeostasis</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description><![CDATA[We assessed whether modification of vitamin D nutritional status during the last trimester of pregnancy affects maternal and neonatal calcium homeostasis. At the end of the first trimester, 40 pregnant women were randomly assigned to either of two groups, and blood taken to assess the basal values of Ca, Pi, Mg, iPTH, 25-OHD, and 1,25(OH)
2D. From the sixth month on, group 1 (+D) received 1000 IU vitamin D
3 daily; group 2 (−D) served as control. At the time of delivery, maternal serum 25-OHD was higher in the +D group (P<0.0005). Ca, Pi, iPTH, and 1,25(OH)
2D were not affected. At term, venous cord 25-OHD levels were also higher in the +D group (P<0.0005), and 1,25(OH)
2D levels slightly lower (P<0.05), but neither Ca, Pi, nor iPTH differed between the two groups. Serum Ca
T
dropped significantly (P<0.002) at 4 days of age in the infants from both groups, although to a lesser extent in these from the +D group (P<0.05). Circulating iPTH increased in both groups. Serum 25-OHD remained low in the −D group, and dropped slightly in the +D group; 1,25(OH)
2D remained stable during the first 4 days of life in the −D group, and increased in the +D group (P<0.001). Our data demonstrate the importance of providing adequate maternal vitamin D stores to ensure better perinatal handling of calcium. This is of particular importance for populations at risk for hypovitaminosis D.]]></description><subject>25-Hydroxyvitamin D 2</subject><subject>ASREGIME ALIMENTAIRE</subject><subject>Biological and medical sciences</subject><subject>CALCIO</subject><subject>CALCIUM</subject><subject>Calcium - blood</subject><subject>Ergocalciferols - analogs & derivatives</subject><subject>Ergocalciferols - blood</subject><subject>Female</subject><subject>Fetal Blood - analysis</subject><subject>Genital system. Reproduction</subject><subject>GESTACION</subject><subject>GESTATION</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>INFA</subject><subject>Infant, Newborn</subject><subject>Magnesium - blood</subject><subject>Medical sciences</subject><subject>NOUVEA</subject><subject>Parathyroid Hormone - blood</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphates - blood</subject><subject>Pregnancy</subject><subject>r)DIETA</subject><subject>Random Allocation</subject><subject>Vitamin D - therapeutic use</subject><subject>VITAMINA D</subject><subject>VITAMINE D</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF2L1DAUhoMo6zj6D1zohch6UT1p0pPEG5F1_YAFwXW9DWmajJE27Sbtwv57M84wt0LgXLzPeXN4CDmn8JYCxXc3AE1TMy7wQuIbCUxhTR-RDQUlapSMPSabE_KUPMv5DwAoDnBGzhiXkkm-IT9-hcWMIVafqrzO8-BGFxezhClW_ZpC3FVzcrtoon14X1157-xSlSy6KZrFDJU1gw3rWP2eRjflxeSQn5Mn3gzZvTjOLbn9fPXz8mt9_f3Lt8uP17XlTC01Zx1ShVgqBQI2FKznvQIvABGlbDxVLdoWhEBhKOsa60TLAT0VTddZtiWvD71zmu5Wlxc9hmzdMJhy3Zq1QIUN56yA7QG0aco5Oa_nFEaTHjQFvXep_7nUe1Falrd3qWnZOz9-sHaj609bR3klf3XMTS4efCqWQj5hEiQVoAr28oB5M2mzSwW5vZGipS2DUrQlHw6xK67ug0s62-CidX1Ixbbup_CfO_8CgNiYTg</recordid><startdate>19860801</startdate><enddate>19860801</enddate><creator>Delvin, E.E.</creator><creator>Salle, B.L.</creator><creator>Glorieux, F.H.</creator><creator>Adeleine, P.</creator><creator>David, L.S.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860801</creationdate><title>Vitamin D supplementation during pregnancy: Effect on neonatal calcium homeostasis</title><author>Delvin, E.E. ; Salle, B.L. ; Glorieux, F.H. ; Adeleine, P. ; David, L.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-43b61966fec7606210cf4d90f70666882f1956c507767a13b2ce75406f172bbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>25-Hydroxyvitamin D 2</topic><topic>ASREGIME ALIMENTAIRE</topic><topic>Biological and medical sciences</topic><topic>CALCIO</topic><topic>CALCIUM</topic><topic>Calcium - blood</topic><topic>Ergocalciferols - analogs & derivatives</topic><topic>Ergocalciferols - blood</topic><topic>Female</topic><topic>Fetal Blood - analysis</topic><topic>Genital system. Reproduction</topic><topic>GESTACION</topic><topic>GESTATION</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>INFA</topic><topic>Infant, Newborn</topic><topic>Magnesium - blood</topic><topic>Medical sciences</topic><topic>NOUVEA</topic><topic>Parathyroid Hormone - blood</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphates - blood</topic><topic>Pregnancy</topic><topic>r)DIETA</topic><topic>Random Allocation</topic><topic>Vitamin D - therapeutic use</topic><topic>VITAMINA D</topic><topic>VITAMINE D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delvin, E.E.</creatorcontrib><creatorcontrib>Salle, B.L.</creatorcontrib><creatorcontrib>Glorieux, F.H.</creatorcontrib><creatorcontrib>Adeleine, P.</creatorcontrib><creatorcontrib>David, L.S.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delvin, E.E.</au><au>Salle, B.L.</au><au>Glorieux, F.H.</au><au>Adeleine, P.</au><au>David, L.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D supplementation during pregnancy: Effect on neonatal calcium homeostasis</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1986-08-01</date><risdate>1986</risdate><volume>109</volume><issue>2</issue><spage>328</spage><epage>334</epage><pages>328-334</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract><![CDATA[We assessed whether modification of vitamin D nutritional status during the last trimester of pregnancy affects maternal and neonatal calcium homeostasis. At the end of the first trimester, 40 pregnant women were randomly assigned to either of two groups, and blood taken to assess the basal values of Ca, Pi, Mg, iPTH, 25-OHD, and 1,25(OH)
2D. From the sixth month on, group 1 (+D) received 1000 IU vitamin D
3 daily; group 2 (−D) served as control. At the time of delivery, maternal serum 25-OHD was higher in the +D group (P<0.0005). Ca, Pi, iPTH, and 1,25(OH)
2D were not affected. At term, venous cord 25-OHD levels were also higher in the +D group (P<0.0005), and 1,25(OH)
2D levels slightly lower (P<0.05), but neither Ca, Pi, nor iPTH differed between the two groups. Serum Ca
T
dropped significantly (P<0.002) at 4 days of age in the infants from both groups, although to a lesser extent in these from the +D group (P<0.05). Circulating iPTH increased in both groups. Serum 25-OHD remained low in the −D group, and dropped slightly in the +D group; 1,25(OH)
2D remained stable during the first 4 days of life in the −D group, and increased in the +D group (P<0.001). Our data demonstrate the importance of providing adequate maternal vitamin D stores to ensure better perinatal handling of calcium. This is of particular importance for populations at risk for hypovitaminosis D.]]></abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>3488384</pmid><doi>10.1016/S0022-3476(86)80396-1</doi><tpages>7</tpages></addata></record> |
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| subjects | 25-Hydroxyvitamin D 2 ASREGIME ALIMENTAIRE Biological and medical sciences CALCIO CALCIUM Calcium - blood Ergocalciferols - analogs & derivatives Ergocalciferols - blood Female Fetal Blood - analysis Genital system. Reproduction GESTACION GESTATION Homeostasis Humans INFA Infant, Newborn Magnesium - blood Medical sciences NOUVEA Parathyroid Hormone - blood Pharmacology. Drug treatments Phosphates - blood Pregnancy r)DIETA Random Allocation Vitamin D - therapeutic use VITAMINA D VITAMINE D |
| title | Vitamin D supplementation during pregnancy: Effect on neonatal calcium homeostasis |
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