Asymmetric Localization of Frizzled and the Establishment of Cell Polarity in the Drosophila Wing
The frizzled gene of Drosophila encodes a transmembrane receptor molecule required for cell polarity decisions in the adult cuticle. In the wing, a single trichome is produced by each cell, which normally points distally. In the absence of frizzled function, the trichomes no longer point uniformly d...
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| Veröffentlicht in: | Molecular cell 2001-02, Vol.7 (2), p.367-375 |
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| creator | Strutt, David I |
| description | The
frizzled gene of
Drosophila encodes a transmembrane receptor molecule required for cell polarity decisions in the adult cuticle. In the wing, a single trichome is produced by each cell, which normally points distally. In the absence of
frizzled function, the trichomes no longer point uniformly distalward. We report that during cell polarization, the Frizzled receptor is localized to the distal cell edge, probably resulting in asymmetric Frizzled activity across the axis of the cell. Furthermore, Frizzled localization correlates with subsequent trichome polarity, suggesting that it may be an instructive cue in the determination of cell polarity. This differential receptor distribution may represent a novel mechanism for amplifying small differences in signaling activity across the axis of a cell. |
| doi_str_mv | 10.1016/S1097-2765(01)00184-8 |
| format | Article |
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frizzled gene of
Drosophila encodes a transmembrane receptor molecule required for cell polarity decisions in the adult cuticle. In the wing, a single trichome is produced by each cell, which normally points distally. In the absence of
frizzled function, the trichomes no longer point uniformly distalward. We report that during cell polarization, the Frizzled receptor is localized to the distal cell edge, probably resulting in asymmetric Frizzled activity across the axis of the cell. Furthermore, Frizzled localization correlates with subsequent trichome polarity, suggesting that it may be an instructive cue in the determination of cell polarity. This differential receptor distribution may represent a novel mechanism for amplifying small differences in signaling activity across the axis of a cell.</description><identifier>ISSN: 1097-2765</identifier><identifier>EISSN: 1097-4164</identifier><identifier>DOI: 10.1016/S1097-2765(01)00184-8</identifier><identifier>PMID: 11239465</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Body Patterning ; Cell Polarity ; Drosophila ; Drosophila - cytology ; Drosophila - embryology ; Drosophila - genetics ; Drosophila Proteins ; frizzled gene ; Frizzled protein ; Frizzled Receptors ; Gene Expression Regulation, Developmental ; Genes, Insect - genetics ; Immunohistochemistry ; Insect Proteins - genetics ; Insect Proteins - metabolism ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Microscopy, Fluorescence ; Models, Biological ; Mutation ; Pupa - cytology ; Pupa - metabolism ; Receptors, G-Protein-Coupled ; Recombinant Fusion Proteins ; Signal Transduction ; Wings, Animal - cytology ; Wings, Animal - embryology ; Wings, Animal - metabolism</subject><ispartof>Molecular cell, 2001-02, Vol.7 (2), p.367-375</ispartof><rights>2001 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-ea99052022ab4927cd7bb64a9fffa5d3d421acc8d8c7876dbff900c9c718b7993</citedby><cites>FETCH-LOGICAL-c557t-ea99052022ab4927cd7bb64a9fffa5d3d421acc8d8c7876dbff900c9c718b7993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1097-2765(01)00184-8$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11239465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strutt, David I</creatorcontrib><title>Asymmetric Localization of Frizzled and the Establishment of Cell Polarity in the Drosophila Wing</title><title>Molecular cell</title><addtitle>Mol Cell</addtitle><description>The
frizzled gene of
Drosophila encodes a transmembrane receptor molecule required for cell polarity decisions in the adult cuticle. In the wing, a single trichome is produced by each cell, which normally points distally. In the absence of
frizzled function, the trichomes no longer point uniformly distalward. We report that during cell polarization, the Frizzled receptor is localized to the distal cell edge, probably resulting in asymmetric Frizzled activity across the axis of the cell. Furthermore, Frizzled localization correlates with subsequent trichome polarity, suggesting that it may be an instructive cue in the determination of cell polarity. This differential receptor distribution may represent a novel mechanism for amplifying small differences in signaling activity across the axis of a cell.</description><subject>Animals</subject><subject>Body Patterning</subject><subject>Cell Polarity</subject><subject>Drosophila</subject><subject>Drosophila - cytology</subject><subject>Drosophila - embryology</subject><subject>Drosophila - genetics</subject><subject>Drosophila Proteins</subject><subject>frizzled gene</subject><subject>Frizzled protein</subject><subject>Frizzled Receptors</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes, Insect - genetics</subject><subject>Immunohistochemistry</subject><subject>Insect Proteins - genetics</subject><subject>Insect Proteins - metabolism</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Microscopy, Fluorescence</subject><subject>Models, Biological</subject><subject>Mutation</subject><subject>Pupa - cytology</subject><subject>Pupa - metabolism</subject><subject>Receptors, G-Protein-Coupled</subject><subject>Recombinant Fusion Proteins</subject><subject>Signal Transduction</subject><subject>Wings, Animal - cytology</subject><subject>Wings, Animal - embryology</subject><subject>Wings, Animal - metabolism</subject><issn>1097-2765</issn><issn>1097-4164</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKAzEUhoMotlYfQclKdDGapDO5rKTUVoWCgorLkEkyNjIzqUkqtE_v9AIuXZ3D4Tu3_wfgHKMbjDC9fcVIsIwwWlwhfI0Q5nnGD0B_W84xzQ_3-QbpgZMYvzooL7g4Bj2MyVDktOgDNYqrprEpOA1nXqvarVVyvoW-gtPg1uvaGqhaA9PcwklMqqxdnDe2TRtibOsavvhaBZdW0LVb6j746BdzVyv44drPU3BUqTras30cgPfp5G38mM2eH57Go1mmi4KlzCohUEEQIarMBWHasLKkuRJVVanCDE1OsNKaG64ZZ9SUVSUQ0kIzzEsmxHAALndzF8F_L21MsnFRdweq1vpllIwKigX5H8SME0KHuAOLHai7j2KwlVwE16iwkhjJjQlya4LcKCwRllsTJO_6LvYLlmVjzV_XXvUOuNsBttPjx9kgo3a21da4YHWSxrt_VvwCe9mXgg</recordid><startdate>20010201</startdate><enddate>20010201</enddate><creator>Strutt, David I</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20010201</creationdate><title>Asymmetric Localization of Frizzled and the Establishment of Cell Polarity in the Drosophila Wing</title><author>Strutt, David I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-ea99052022ab4927cd7bb64a9fffa5d3d421acc8d8c7876dbff900c9c718b7993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Body Patterning</topic><topic>Cell Polarity</topic><topic>Drosophila</topic><topic>Drosophila - cytology</topic><topic>Drosophila - embryology</topic><topic>Drosophila - genetics</topic><topic>Drosophila Proteins</topic><topic>frizzled gene</topic><topic>Frizzled protein</topic><topic>Frizzled Receptors</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes, Insect - genetics</topic><topic>Immunohistochemistry</topic><topic>Insect Proteins - genetics</topic><topic>Insect Proteins - metabolism</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Microscopy, Fluorescence</topic><topic>Models, Biological</topic><topic>Mutation</topic><topic>Pupa - cytology</topic><topic>Pupa - metabolism</topic><topic>Receptors, G-Protein-Coupled</topic><topic>Recombinant Fusion Proteins</topic><topic>Signal Transduction</topic><topic>Wings, Animal - cytology</topic><topic>Wings, Animal - embryology</topic><topic>Wings, Animal - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strutt, David I</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - 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frizzled gene of
Drosophila encodes a transmembrane receptor molecule required for cell polarity decisions in the adult cuticle. In the wing, a single trichome is produced by each cell, which normally points distally. In the absence of
frizzled function, the trichomes no longer point uniformly distalward. We report that during cell polarization, the Frizzled receptor is localized to the distal cell edge, probably resulting in asymmetric Frizzled activity across the axis of the cell. Furthermore, Frizzled localization correlates with subsequent trichome polarity, suggesting that it may be an instructive cue in the determination of cell polarity. This differential receptor distribution may represent a novel mechanism for amplifying small differences in signaling activity across the axis of a cell.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11239465</pmid><doi>10.1016/S1097-2765(01)00184-8</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular cell, 2001-02, Vol.7 (2), p.367-375 |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Body Patterning Cell Polarity Drosophila Drosophila - cytology Drosophila - embryology Drosophila - genetics Drosophila Proteins frizzled gene Frizzled protein Frizzled Receptors Gene Expression Regulation, Developmental Genes, Insect - genetics Immunohistochemistry Insect Proteins - genetics Insect Proteins - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Microscopy, Fluorescence Models, Biological Mutation Pupa - cytology Pupa - metabolism Receptors, G-Protein-Coupled Recombinant Fusion Proteins Signal Transduction Wings, Animal - cytology Wings, Animal - embryology Wings, Animal - metabolism |
| title | Asymmetric Localization of Frizzled and the Establishment of Cell Polarity in the Drosophila Wing |
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